ID F2Z2J7_HUMAN Unreviewed; 477 AA.
AC F2Z2J7;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Tubulin tyrosine ligase like 7 {ECO:0000313|Ensembl:ENSP00000434146.1};
GN Name=TTLL7 {ECO:0000313|Ensembl:ENSP00000434146.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434146.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000434146.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H.,
RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C.,
RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R.,
RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A.,
RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.,
RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.,
RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R.,
RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D.,
RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A.,
RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S.,
RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A.,
RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S.,
RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A.,
RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L.,
RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z.,
RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R.,
RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C.,
RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M.,
RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000434146.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AC104454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL035706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL138844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KC876883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF454977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF454979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF454980; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F2Z2J7; -.
DR SMR; F2Z2J7; -.
DR MassIVE; F2Z2J7; -.
DR PeptideAtlas; F2Z2J7; -.
DR ProteomicsDB; 23736; -.
DR Ensembl; ENST00000474957.5; ENSP00000434146.1; ENSG00000137941.17.
DR UCSC; uc001djf.4; human.
DR HGNC; HGNC:26242; TTLL7.
DR VEuPathDB; HostDB:ENSG00000137941; -.
DR GeneTree; ENSGT00940000159078; -.
DR HOGENOM; CLU_504275_0_0_1; -.
DR ChiTaRS; TTLL7; human.
DR Proteomes; UP000005640; Chromosome 1.
DR Bgee; ENSG00000137941; Expressed in corpus callosum and 154 other cell types or tissues.
DR ExpressionAtlas; F2Z2J7; baseline and differential.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF147; TUBULIN POLYGLUTAMYLASE TTLL7; 1.
DR Pfam; PF03133; TTL; 1.
DR PROSITE; PS51221; TTL; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F2Z2J7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT REGION 204..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..132
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 229..244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 55446 MW; F6B31130A070AB61 CRC64;
MCRPGQPPGS ESVCFEVLGF DILLDRKLKP WLLEINRAPS FGTDQKIDYD VKRGVLLNAL
KLLNIRTSDK RRNLAKQKAE AQRRLYGQNS IKRLLPGSSD WEQQRHQLER RKEELKERLA
QVRKQISREE HENRHMGNYR RIYPPEDKAL LEKYENLLAV AFQTFLSGRA ASFQRELNNP
LKRMKEEDIL DLLEQCEIDD EKLMGKTTKT RGPKPLCSMP ESTEIMKRPK YCSSDSSYDS
SSSSSESDEN EKEEYQNKKR EKQVTYNLKP SNHYKLIQQP SSIRRSVSCP RSISAQSPSS
GDTRPFSAQQ MISVSRPTSA SRSHSLNRAS SYMRHLPHSN DACSTNSQVS ESLRQLKTKE
QEDDLTSQTL FVLKDMKIRF PGKSDAESEL LIEDIIDNWK YHKTKVASYW LIKLDSVKQR
KVLDIVKTSI RTVLPRIWKV PDVEEVNLYR IFNRVFNRLL WSRGQGLWNC FCDSGYV
//
