ID F2Z497_MOUSE Unreviewed; 782 AA.
AC F2Z497;
DT 31-MAY-2011, integrated into UniProtKB/TrEMBL.
DT 31-MAY-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=RIKEN cDNA D130043K22 gene {ECO:0000313|Ensembl:ENSMUSP00000116004.2};
GN Name=D130043K22Rik {ECO:0000313|Ensembl:ENSMUSP00000116004.2,
GN ECO:0000313|MGI:MGI:3036268};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000116004.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000116004.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116004.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000116004.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000116004.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; F2Z497; -.
DR SMR; F2Z497; -.
DR MaxQB; F2Z497; -.
DR ProteomicsDB; 357896; -.
DR Antibodypedia; 2465; 135 antibodies from 27 providers.
DR Ensembl; ENSMUST00000141572.8; ENSMUSP00000116004.2; ENSMUSG00000006711.16.
DR AGR; MGI:3036268; -.
DR MGI; MGI:3036268; D130043K22Rik.
DR VEuPathDB; HostDB:ENSMUSG00000006711; -.
DR GeneTree; ENSGT00940000161462; -.
DR HOGENOM; CLU_009448_0_0_1; -.
DR ChiTaRS; D130043K22Rik; mouse.
DR Proteomes; UP000000589; Chromosome 13.
DR Bgee; ENSMUSG00000006711; Expressed in lumbar dorsal root ganglion and 118 other cell types or tissues.
DR ExpressionAtlas; F2Z497; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029865; KIAA0319-like.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR46182:SF1; DYSLEXIA-ASSOCIATED PROTEIN KIAA0319; 1.
DR PANTHER; PTHR46182; FI19480P1; 1.
DR SMART; SM00765; MANEC; 1.
DR SMART; SM00089; PKD; 4.
DR SUPFAM; SSF49299; PKD domain; 3.
DR PROSITE; PS50986; MANSC; 1.
DR PROSITE; PS50093; PKD; 2.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Proteomics identification {ECO:0007829|EPD:F2Z497,
KW ECO:0007829|MaxQB:F2Z497};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..782
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003291022"
FT DOMAIN 13..99
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 466..530
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 554..633
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 168..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 84454 MW; B6725C645BCC3A05 CRC64;
MVSPPGVLSS LLLLAAMAGG SSQQCSEGRT YSDAIISPNP ETIRIMRVSQ TFSVGDCTAA
CCDLLTCDLA WWFEGSCYLV KCMRSENCEP RTTGPIRSYL TFVRRPVQRP GQLLDYGDMM
LSRGSPSGAW GDSLEDLRKD LPFLGKDGGP EETTEYSDEY KDLERGLLQP SNQQDPRGSA
EYPDWSLLPS NEGGFNATAT GDNSAASMEK LQDPTPHPLD QEQLQALNES TWSPTPGHSS
ISSVWPSSAS PLPTEEGLEG EETLQLQEQP SNSSGKEVPM PSHNPSPASL ESSPATTEKN
SNFTVTPRSR KHSTPTFPTS TVLTGLTPPP WPLSPTASRT VKALAVSAGD NLVLTLPDRE
AELKASVEPA PPADTTYSYE WSLMSHPVDF QGKIKQENKP TLHLSQLSVG LYAFRVAVSS
ENAFGEGYVN VTVMPAARVN QPPVAVVSPQ TQELSVPLTS ALIDGSQSTD DTEIVSYHWE
EVDGPFLGEE FPADTPILRL SNLVPGNYTF RLTITDSDGA TNSTTASLVI RDAVDYPPVA
NAGPNQTITL PQNTIILNGN QSSDDHQIVL YEWFAGPGGE SKEMVMQGAQ TPYLHLSELQ
EGEYTFQLMV TDSSGQQSTA LVAVTVQAEN NQAPVAVAGP DKELVFPVQS ATLDGSRSSD
DHGIVCYHWE HIRGPSAVEM ENVDKAIATV TGLQVGIYHF RLTVRDQQGL SSTSTLTVAV
KKENNSPPRA QAGGRHVLIL PNNSITLDGS RSTDDRGIVS YLWIRDGQSP AAGTPRRMAW
WS
//
