ID F3AI83_9FIRM Unreviewed; 702 AA.
AC F3AI83;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=UvrD-like helicase ATP-binding domain-containing protein {ECO:0000259|PROSITE:PS51198};
GN ORFNames=HMPREF0987_00157 {ECO:0000313|EMBL:EGG90282.1};
OS Lachnospiraceae bacterium 9_1_43BFAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658088 {ECO:0000313|EMBL:EGG90282.1, ECO:0000313|Proteomes:UP000003620};
RN [1] {ECO:0000313|EMBL:EGG90282.1, ECO:0000313|Proteomes:UP000003620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9_1_43BFAA {ECO:0000313|EMBL:EGG90282.1,
RC ECO:0000313|Proteomes:UP000003620};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA Yandava C., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 9_1_43BFAA.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGG90282.1}.
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DR EMBL; ACTX01000001; EGG90282.1; -; Genomic_DNA.
DR AlphaFoldDB; F3AI83; -.
DR eggNOG; COG3973; Bacteria.
DR HOGENOM; CLU_010312_4_0_9; -.
DR Proteomes; UP000003620; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000003620}.
FT DOMAIN 203..537
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 224..231
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 702 AA; 82137 MW; E231FA30414E405A CRC64;
MKADVKKDGK LFLAEVSDKL RDRLTKLAET LLAGQQEIEN MHAYYWENYT EMDQYGYEDF
DNQQALLHQI NANNESQLLY QRFQKMADAP FFGRVDFLYD GDEEAEIFYI GIGNFAERTG
AIPLIYDWRA PVSGLFYDYD KGPASYEAPG GTMEGTIEAK WQYKIQAGKM IYGFESDVKI
DDDILKKELG QNGDVQLKNI VRTIQKEQND IIRNTKDKIL VIQGAAGSGK TSVALHRIAY
LLYHDREHLK SSNILVLSPS GVFSDYISHI LPELGEENIR EMSFDLFAYQ ELKGIVPDCE
DRYHQIERQM EGMSKEAQAR YELKQSQAYI GAVEGFLVGL EEDLVELKEF EWRQMKKTEE
ELIELFYFKF QEIPLLERMY AVMDYVVDEF ETLYDRDLSE EELAAVREKF DQMYVTRDVY
RIYNWFLEEN GWEQLPDVPY ESRMLSYEDV FPMLYLKYRL SGKAKHKQIK HLVIDEMQDY
SYLQYAILET LFSCRMTILG DRAQTMDGKI QDVLTFLPKI FGKEIRTIIM NKSYRNTIEI
ARYAEQITNV TGLEFLERHG KAVEEKTVSG IVGALRDIEG HLHLRKDGVQ IKEAFSETAA
DRLEHTEDAF ETAAILLRTE AEARMVYEYL KEQREDIHYI DRDSSHFEKG VTVTTFYLAK
GLEFDQVFVL REQTESAFER QADYICATRA LHELYLYYLE EK
//
