ID F3AL69_9FIRM Unreviewed; 1321 AA.
AC F3AL69;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=HMPREF0987_01193 {ECO:0000313|EMBL:EGG86235.1};
OS Lachnospiraceae bacterium 9_1_43BFAA.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=658088 {ECO:0000313|EMBL:EGG86235.1, ECO:0000313|Proteomes:UP000003620};
RN [1] {ECO:0000313|EMBL:EGG86235.1, ECO:0000313|Proteomes:UP000003620}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9_1_43BFAA {ECO:0000313|EMBL:EGG86235.1,
RC ECO:0000313|Proteomes:UP000003620};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA Ambrose C., Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA Gearin G., Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E.R.,
RA Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., White J.,
RA Yandava C., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium 9_1_43BFAA.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGG86235.1}.
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DR EMBL; ACTX01000006; EGG86235.1; -; Genomic_DNA.
DR eggNOG; COG2304; Bacteria.
DR HOGENOM; CLU_259826_0_0_9; -.
DR Proteomes; UP000003620; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003620};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 514..680
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT COILED 135..162
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1321 AA; 147437 MW; 08CA801810BC0473 CRC64;
MGTGLQMIVG MLAALVSVCL LIVVHRKQRL VWSAVFVLLG ITTVLAGIFI FTGSERKEDE
KTASAEQLED VYIGLAYGFM EEEAYEEAEI FLENYLSSGV YDDAYLLARA RLYGLQENYD
GAEGLYRMLI DRKSKAAGRN ELKEELEVIE RAKKEADEDA REDAKSLLKE AASSCTEKQT
GTEDAVSYYL AVQKEHDGEE EEKKADIPDG EIWKLREMKL AKMQGQIQEE DYEEIAQEMN
AWEDSSQLLV FSELYRQGLI STSMLRKNEE LQAKTEQAKQ ALSWVNKQKK GYRYTGEDKK
LIDQTLKQLE KASDDSEDAY DFWMRDRLLE AAGKEEEKET SKLYMQASRL AYESGDQTSA
NSCLDKALDT VARSEDAAYR GPAGELNRIL SEKEDKEQLK EIDTYAKLTV DHIVPIVDHS
QDTDGQKEET FQENKEERQE DFTQYVTDTV NQKAASVSIS GIDTKEFETV RAVVSLEEGI
ADTEEKFRGN VEILDCGVEI PDYKVKKLEY DTVNIALCCD NSGSMEGEKI ENLKKAVSTF
VGKLADEVNI GIVPFGSGVL EGVCEPGSSR EKLEQSVESF RSDSGTNIYS GVEYTLSMLA
KEKDALNIAV IMSDGQDSIP SEEQLQKITS ACENGNILLY SMGLGADVES EVLSTYSDAG
NGAYVFVSDS NSLYSFYQYI YQISKNRYEI EYQAVDTMTQ SRTLRVEHKG HRKIYDERSY
YLYENDLTEE DLGPESDLQI QDMIFYGLDT KLLYESPAPQ KVRLTGKDLK KENKISVSLH
GAMEYELECK YESDTSWEIT IPARAACGVY DVYVTANGER RVFPSGLVIT SGDLNTVRYG
NYIFTSTGKE VCGDTTKLTG YIRMNGWLGF QDSVQLEGDL KKDPEVLMRC RRSYVQYDRN
TAKGYAKHLA EYGMYASLPG FSEITLYNDP LTDASSDKYP VKPAVSNGAF ILQDFSRIDY
AKIALYPNQA VVEFDSVQTE LPFQDAVLKT AESESPFAFK FDHAEQIIMN DKQIGCEISL
SLGEEDEKNY HALFGNMPIY CNLGTAELNL NTLSGDVSAK VLVNVAMLCD GMGLELQWKE
WKLDGVELYA DYPVNTTISG VPVTFSDFSL GVEEISSIDK LDMRELLKLK YKGGFEVAVA
KVSEFKPGLE EWVGDVSLAS LDQVSLEFQL SRKYISVAAT AKLLEAVQIG DCTLELGEGI
SYTNMLLGMQ GETVNGFRGE VGVGIKMEKD NCMFNVRGAA ELALTNKVCG IGASGELEAN
VSWWVLAVQT QAKGQGFIGV YEQHNGVWAF GLHGQTSDPG DKGIHLVWAS ENPELSSKTL
S
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