ID   F3BDC4_9FIRM            Unreviewed;       278 AA.
AC   F3BDC4;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 36.
DE   RecName: Full=Transketolase N-terminal domain-containing protein {ECO:0000259|Pfam:PF00456};
GN   ORFNames=HMPREF9477_01944 {ECO:0000313|EMBL:EGG80581.1};
OS   Lachnospiraceae bacterium 2_1_46FAA.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=742723 {ECO:0000313|EMBL:EGG80581.1, ECO:0000313|Proteomes:UP000018451};
RN   [1] {ECO:0000313|EMBL:EGG80581.1, ECO:0000313|Proteomes:UP000018451}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2_1_46FAA {ECO:0000313|EMBL:EGG80581.1,
RC   ECO:0000313|Proteomes:UP000018451};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Daigneault M., Strauss J.,
RA   Ambrose C., Allen-Vercoe E., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C., Murphy C.,
RA   Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA   Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 2_1_46FAA.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGG80581.1}.
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DR   EMBL; ADLB02000002; EGG80581.1; -; Genomic_DNA.
DR   AlphaFoldDB; F3BDC4; -.
DR   STRING; 742723.HMPREF9477_01944; -.
DR   eggNOG; COG3959; Bacteria.
DR   HOGENOM; CLU_009227_4_1_9; -.
DR   OrthoDB; 8732661at2; -.
DR   Proteomes; UP000018451; Unassembled WGS sequence.
DR   CDD; cd02012; TPP_TK; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR049557; Transketolase_CS.
DR   InterPro; IPR005474; Transketolase_N.
DR   PANTHER; PTHR47514; TRANSKETOLASE N-TERMINAL SECTION-RELATED; 1.
DR   PANTHER; PTHR47514:SF1; TRANSKETOLASE N-TERMINAL SECTION-RELATED; 1.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   PROSITE; PS00801; TRANSKETOLASE_1; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018451};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          8..262
FT                   /note="Transketolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00456"
SQ   SEQUENCE   278 AA;  30392 MW;  55454ADA228D7CDD CRC64;
     MNKLELMKVA NEVRKGAVTA VYNAKSGHPG GSLSAADIYT YLFFEEMNID PADPKKDDRD
     RFVLSKGHTA PGYYAALANR GFFPVEDLKT LRKVGSYLQG HPDMKHIPGV DMSSGSLGQG
     ISAAVGMAIS GKLRKKDYRV YTLLGDGEIQ EGQVWEAAML AAHHNLDNLV VIVDNNNLQI
     DGSIDEVNSP YPIDKKFEAF NFHVINVDGH DFDALDAAFK EARETKGQPT AIIAKTIKGK
     NVSFMENQAS WHGAAPNEEQ YAVAMADLEK VGEALCQM
//