ID F3L0Z5_9GAMM Unreviewed; 719 AA.
AC F3L0Z5;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN ORFNames=EYZ66_07025 {ECO:0000313|EMBL:QHJ88067.1}, IMCC3088_1087
GN {ECO:0000313|EMBL:EGG29940.1};
OS Aequoribacter fuscus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae;
OC Aequoribacter.
OX NCBI_TaxID=2518989 {ECO:0000313|EMBL:EGG29940.1, ECO:0000313|Proteomes:UP000005615};
RN [1] {ECO:0000313|EMBL:EGG29940.1, ECO:0000313|Proteomes:UP000005615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMCC3088 {ECO:0000313|EMBL:EGG29940.1,
RC ECO:0000313|Proteomes:UP000005615};
RX PubMed=21551310; DOI=10.1128/JB.05111-11;
RA Jang Y., Oh H.M., Kang I., Lee K., Yang S.J., Cho J.C.;
RT "Genome sequence of strain IMCC3088, a proteorhodopsin-containing marine
RT bacterium belonging to the OM60/NOR5 clade.";
RL J. Bacteriol. 193:3415-3416(2011).
RN [2] {ECO:0000313|EMBL:QHJ88067.1, ECO:0000313|Proteomes:UP000464557}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMCC3088 {ECO:0000313|EMBL:QHJ88067.1,
RC ECO:0000313|Proteomes:UP000464557};
RA Li S.-H.;
RT "Halieaceae_genomes.";
RL Submitted (FEB-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC {ECO:0000256|ARBA:ARBA00008465}.
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DR EMBL; AEIG01000026; EGG29940.1; -; Genomic_DNA.
DR EMBL; CP036423; QHJ88067.1; -; Genomic_DNA.
DR RefSeq; WP_009575377.1; NZ_CP036423.1.
DR AlphaFoldDB; F3L0Z5; -.
DR STRING; 2518989.IMCC3088_1087; -.
DR KEGG; afus:EYZ66_07025; -.
DR eggNOG; COG1884; Bacteria.
DR eggNOG; COG2185; Bacteria.
DR OrthoDB; 9762378at2; -.
DR Proteomes; UP000005615; Unassembled WGS sequence.
DR Proteomes; UP000464557; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR CDD; cd03679; MM_CoA_mutase_alpha_like; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR006098; MMCoA_mutase_a_cat.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS00544; METMALONYL_COA_MUTASE; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:QHJ88067.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005615}.
FT DOMAIN 588..719
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 719 AA; 78181 MW; DFDDFB4E94F5399F CRC64;
MSDSIYDPND ATPDNWKAVA ESQMRGKSID DLVWHTPEDI DVKPLYTMED LDGLQYTNTM
PGMSPYIRGP QATMYAGRPW TIRQYAGFST AEESNAFYRK ALAAGGQGVS VAFDLATHRG
YDSDHPRVSG DVGKAGVAID SVEDMKILFN GIPLDKVSVS MTMNGAVLPV LAGYIVAAEE
QGVGPEQLAG TIQNDILKEF MVRNTYIYPP APSMRIIGDI IAYCSQNMPK FNTISISGYH
IQEAGANAAL ELAYTLADGK EYIRTAIAAG LDIDAFAPRL SFFWGIGMNF YMEIAKLRAA
RLLWAKIVSE FNPKNPKSSM LRTHSQTSGW SLTEQDPYNN VVRTTIEAMA AVFGGTQSLH
TNALDEAIAL PTEFSARIAR NTQLIIQEET GITKVVDPWG GSYFMENLTQ SIADKAWELI
EEVEAAGGMA KAIETGMPKL KIEEAAAKKQ ARIDRGEDVI VGVNKYKTES EEEVDVLSID
DQAVRESQIK RLQAIRASRD EAAVHEALTA LTACAQQGEG NLLDLAVKAT RLRATVGEIS
EALENEYGRF NATAQTVSGV YGAAFDEDDD WKMISQDIEQ FINDFGRRPR MLVCKMGQDG
HDRGAKVVAT AFADVGFDVD LSPMFSTPEE VAKQAIENDV HVVGASSLAA GHKTLIPALV
EELRKQGADD IVVIAGGVIP KQDYQGLYDA GVRCIFGPGT PIPVSARAVL DAVRESLAE
//
