ID   F3PAK2_9ACTO            Unreviewed;       386 AA.
AC   F3PAK2;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=Prephenate dehydrogenase {ECO:0000313|EMBL:EGF53573.1};
GN   ORFNames=HMPREF9056_02059 {ECO:0000313|EMBL:EGF53573.1};
OS   Actinomyces sp. oral taxon 170 str. F0386.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=762963 {ECO:0000313|EMBL:EGF53573.1, ECO:0000313|Proteomes:UP000004404};
RN   [1] {ECO:0000313|EMBL:EGF53573.1, ECO:0000313|Proteomes:UP000004404}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0386 {ECO:0000313|EMBL:EGF53573.1,
RC   ECO:0000313|Proteomes:UP000004404};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EGF53573.1}.
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DR   EMBL; AFBL01000053; EGF53573.1; -; Genomic_DNA.
DR   RefSeq; WP_009404496.1; NZ_GL882544.1.
DR   AlphaFoldDB; F3PAK2; -.
DR   STRING; 762963.HMPREF9056_02059; -.
DR   eggNOG; COG0287; Bacteria.
DR   HOGENOM; CLU_055968_1_1_11; -.
DR   OrthoDB; 9802008at2; -.
DR   Proteomes; UP000004404; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0008977; F:prephenate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0004665; F:prephenate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006571; P:tyrosine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.10.3660.10; 6-phosphogluconate dehydrogenase C-terminal like domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR046825; PDH_C.
DR   InterPro; IPR046826; PDH_N.
DR   InterPro; IPR003099; Prephen_DH.
DR   PANTHER; PTHR21363; PREPHENATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR21363:SF0; PREPHENATE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF20463; PDH_C; 1.
DR   Pfam; PF02153; PDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51176; PDH_ADH; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          14..292
FT                   /note="Prephenate/arogenate dehydrogenase"
FT                   /evidence="ECO:0000259|PROSITE:PS51176"
SQ   SEQUENCE   386 AA;  39092 MW;  AD733137AB323493 CRC64;
     MSTPEPRTSV STHGPVLIVG TGLLGTSLAL ALWTAGVEVQ LSDTSPTSLA LARDMGAGAL
     HGKDSPEPQI VVVATPPDVT ADVVVAQLTA HPNAVVTDVA SVKERVVAEV RARAGAEACR
     YVGSHPMAGR ERSGAGAADS DLFAGRPWVV VGQDSDPEAE LIVRNLAVDV GATPVRMGAA
     EHDAAVAAVS HMPQLISSLV AARLEELGES ALALSGQGLR DVTRIAASDP RLWSAIIVGN
     AGPVADLLRQ ISDDLSALIE GIEAAACEPD STEYTAPGAA HAIAPGAVGA ITDVMARGNA
     GRARIPGKHG GAPRRYAEVQ VLVPDAAGEL GRLFSDVGAA GVNIEDFSLE HSAGQSAGIA
     LISVLPAAAQ GLEEALDVKG WRVVAG
//