ID F3PGV1_9BACE Unreviewed; 755 AA.
AC F3PGV1;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=TrkA protein {ECO:0000313|EMBL:EGF52966.1};
GN ORFNames=HMPREF9445_01295 {ECO:0000313|EMBL:EGF52966.1};
OS Bacteroides clarus YIT 12056.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=762984 {ECO:0000313|EMBL:EGF52966.1, ECO:0000313|Proteomes:UP000010321};
RN [1] {ECO:0000313|EMBL:EGF52966.1, ECO:0000313|Proteomes:UP000010321}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIT 12056 {ECO:0000313|EMBL:EGF52966.1,
RC ECO:0000313|Proteomes:UP000010321};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGF52966.1}.
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DR EMBL; AFBM01000010; EGF52966.1; -; Genomic_DNA.
DR RefSeq; WP_009121456.1; NZ_GL882585.1.
DR AlphaFoldDB; F3PGV1; -.
DR STRING; 762984.SAMN05444376_1272; -.
DR eggNOG; COG0475; Bacteria.
DR eggNOG; COG0490; Bacteria.
DR HOGENOM; CLU_020579_0_0_10; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000010321; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 2.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 2.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 2.
DR PROSITE; PS51202; RCK_C; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..520
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 526..544
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 579..663
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
FT DOMAIN 667..751
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 755 AA; 83178 MW; 716AB5427761C85D CRC64;
MSHLAPLIAD LALILICAGV MTLLFKKLKQ PLVLGYVVAG FLASPHMTYT PSVMDTANIQ
TWADIGVIFL LFALGLEFSF KKIVKVGGAA IIAACTIIFC MILLGVAVGT AFGWKRMDCI
FLGGMIAMSS TTIIYKAFDD LGIRKKQFTG LVLSVLILED ILAIVLMVML STMAVSHNFE
GTEMLGSIAK LLFFLILWFV VGIYLIPVLL KKCRKLMSEE TLLIVSLGLC FGMVVLAAHT
GFSAAFGAFI MGSILAETVE AESIERLVKP VKDLFGAIFF VSVGMMVDPL MIVEYAGPIV
VITLAVIAGQ SLFGTLGVLL AGQPLKTAMQ CGFSLTQIGE FAFIIASLGV SLHVTSHFLY
PIVVAVSVIT TFLTPYMIRF AEPASNFVDT HLPERWQKFL LHYASGSQTV NHESLWKKLI
LALLRITVVY SIVSVAVIAI AFRFLVPFFK ESLPGVWGPL LSALVIILFI APFLRAIMIK
KNHSVEFVTL WRDSRGNRAP LVATIVLRIL LAVSFVMFVI AGLFKLSVGL VFGVAVLLVT
VMILSRQLKR QSIMIERTFF QNLRSRDMRA EYLGEKKPEY AGRLLSRDLH LTDYEIPGES
AWAGKTLAEL NFGKRYGVHV VSILRGRKRI NIPGASVRLF PLDKIQVIAT DEELNVFGEE
MDRLSTVATD VVEKSEMILR QLRIDANSPF LGKTLKDAGI REKYHCLIVG VERGEETLHA
PDVHEPFVAG DVVWIVGENV DVYKLVGEND ENVDL
//
