ID F4BA72_ACIHW Unreviewed; 885 AA.
AC F4BA72;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN OrderedLocusNames=Ahos_1186 {ECO:0000313|EMBL:AEE94069.1};
OS Acidianus hospitalis (strain W1).
OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Acidianus.
OX NCBI_TaxID=933801 {ECO:0000313|EMBL:AEE94069.1, ECO:0000313|Proteomes:UP000008458};
RN [1] {ECO:0000313|EMBL:AEE94069.1, ECO:0000313|Proteomes:UP000008458}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W1 {ECO:0000313|EMBL:AEE94069.1,
RC ECO:0000313|Proteomes:UP000008458};
RX PubMed=21607549; DOI=10.1007/s00792-011-0379-y;
RA You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA She Q., Liu S.J., Garrett R.A.;
RT "Genomic analysis of Acidianus hospitalis W1 a host for studying
RT crenarchaeal virus and plasmid life cycles.";
RL Extremophiles 15:487-497(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=W1;
RA You X.Y., Liu C., Wang S.Y., Jiang C.Y., Shah S.A., Prangishvili D.,
RA Liu S.J., Garrett R.A.;
RT "Genomic analyses of Acidianus hospitalis W1 a host for studying
RT crenarchaeal virus and plasmid life cycles.";
RL Extremophiles 0:0-0(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632,
CC ECO:0000256|RuleBase:RU000442};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; CP002535; AEE94069.1; -; Genomic_DNA.
DR AlphaFoldDB; F4BA72; -.
DR STRING; 933801.Ahos_1186; -.
DR KEGG; aho:Ahos_1186; -.
DR eggNOG; arCOG15272; Archaea.
DR HOGENOM; CLU_000203_6_0_2; -.
DR Proteomes; UP000008458; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd05783; DNA_polB_B1_exo; 1.
DR Gene3D; 1.10.287.1390; -; 2.
DR Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10322:SF20; DNA POLYMERASE 1; 1.
DR PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442}.
FT DOMAIN 136..339
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 495..848
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
SQ SEQUENCE 885 AA; 102112 MW; BB8520214E76B075 CRC64;
MLKEYFFHLY NVAKQITLFD FSIKQETHSE GKGVEKEEEV QQLEVENKRG QVEWIKEAKE
GRTYYLLGVD YDGKKGKAVM KLYDPETQEA AILYDNTGHK SYFLVDLDPE KVRKIAKIIR
DPSFDHLEVV TKIDPYTWKP ITLTKIVVKD PLAVRRMRNY APKAYEAHIK YFNNYIYDMQ
LIPGMPYKVN KGRLEAIIPK VDTEEVTKAF QDSDEVTKEM ALQWAPLFES EIPSIKRVAV
DIEVFTPMKG RVPDPYKAEF PIISISLAGS DGLKKVLVIE REDVGEGNTN NEGISVEKFK
TEREMLSRFF EIVKTYPLLL TFNGDDFDVP YIYFRSLKLG FFPEEIPFDI GSRETKFLPG
FHIDLYRFFF NKAVRNYAFE GKYSEYNLDA VASALLGMSK VKVDSLISDL DISKLIQYNF
RDSEITLKLT TFNNDLTWKL IVLFARISKL GIEELTRTEI SAWVKNLYYW EHRKRNWLIP
LKEEILQRSS TLKTSAVIKG KGYKGAVVID PPVGVFFNVT VLDFASLYPS IIRTWNLSYE
TVDIENCKNI VDVKDETGQV LHHVCMDRPG ITAVITGLLR DFRVKIYKKK SKQKDLDPER
KMMYEVVQRG MKVFINATYG VFGAESFPLY APAVAESVTA LGRYVITSTV KKAQEVGTRV
LYGDTDSLFL YQPTQEQLNT IIKWVKENFK LDLELDKSYR FVAFSGLKKN YFGVFTDSTF
DIKGMLAKKR NTPEFLKEAF KEVKDLMGTI NSPSDLEKVK KEVAEKVKSV YDRLKNKEYN
LDELAFRVML SKDLDSYTKN TPQHVKAAMQ LRALGIQVLP RDMILFVKVK SKEGVKPVQL
AKLTEIDLDK YYDAVKSTFE QLLKSLGISW DEIASTISID SFFKF
//
