ID   F4BV42_METSG            Unreviewed;       465 AA.
AC   F4BV42;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=HMG-CoA synthase {ECO:0000313|EMBL:AEB69612.1};
GN   OrderedLocusNames=MCON_3359 {ECO:0000313|EMBL:AEB69612.1};
OS   Methanothrix soehngenii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC
OS   103675 / OCM 69 / GP-6) (Methanosaeta concilii).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanotrichales; Methanotrichaceae; Methanothrix.
OX   NCBI_TaxID=990316 {ECO:0000313|EMBL:AEB69612.1, ECO:0000313|Proteomes:UP000007807};
RN   [1] {ECO:0000313|EMBL:AEB69612.1, ECO:0000313|Proteomes:UP000007807}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6
RC   {ECO:0000313|Proteomes:UP000007807};
RX   PubMed=21571998; DOI=10.1128/JB.05031-11;
RA   Barber R.D., Zhang L., Harnack M., Olson M.V., Kaul R., Ingram-Smith C.,
RA   Smith K.S.;
RT   "Complete genome sequence of Methanosaeta concilii, a specialist in
RT   aceticlastic methanogenesis.";
RL   J. Bacteriol. 193:3668-3669(2011).
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. HMG-CoA synthase
CC       family. {ECO:0000256|ARBA:ARBA00007061}.
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DR   EMBL; CP002565; AEB69612.1; -; Genomic_DNA.
DR   RefSeq; WP_013720624.1; NC_015416.1.
DR   AlphaFoldDB; F4BV42; -.
DR   STRING; 990316.MCON_3359; -.
DR   GeneID; 10462576; -.
DR   KEGG; mcj:MCON_3359; -.
DR   HOGENOM; CLU_008065_3_2_2; -.
DR   InParanoid; F4BV42; -.
DR   Proteomes; UP000007807; Chromosome.
DR   GO; GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
DR   GO; GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro.
DR   GO; GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IEA:InterPro.
DR   CDD; cd00827; init_cond_enzymes; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   InterPro; IPR013746; HMG_CoA_synt_C_dom.
DR   InterPro; IPR013528; HMG_CoA_synth_N.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43323; 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE; 1.
DR   PANTHER; PTHR43323:SF2; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR   Pfam; PF08540; HMG_CoA_synt_C; 1.
DR   Pfam; PF01154; HMG_CoA_synt_N; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007807}.
FT   DOMAIN          22..194
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01154"
FT   DOMAIN          203..430
FT                   /note="Hydroxymethylglutaryl-coenzyme A synthase C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08540"
SQ   SEQUENCE   465 AA;  51438 MW;  D7E2BDE5C69A7F93 CRC64;
     MTGIFGNSSK SASISGNSPF KEAVGIDDLA VYIPQLYLPL EGEFSRRREI DPGKLTRGIG
     IERMAIPDAH EDAATMAAMS LLELMRRCDL LPEDIGKIHI GTESAVDEAK AIGTYVIGML
     EKVYGPGSFQ HCSTVEFKSA CIGTTLALES ISYWVAADEG ERVGVVIASD VAKYPLGSSG
     EYTQGAGSVS LLVKKNPRIA ALEQIYGCFT RDENDFFRPT GCTMATVNGK HSNQCYLDAM
     QGAFASFAAK AARKGIISPK NGECTTDWID HLLFHIPYPR MIEYASAAIF RQDWKNSSRW
     SDVEAEIGPE PEAGNYDDLE RYRLDLARYA RSFARSRQFL EAYNARVIDS AALSRSIGNI
     YTGSIYLGLA SLLELQKLRA HERLCFGAYG SGCSALVFSA RVSSEFSSVP SRDLFERLEK
     RREISLEEYE LLHEGVRKES LIQPSGEFAL AQIDHQGYRH YEYMS
//