ID F4BVC0_METSG Unreviewed; 267 AA.
AC F4BVC0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Alpha-acetolactate decarboxylase {ECO:0000256|ARBA:ARBA00020164};
DE EC=4.1.1.5 {ECO:0000256|ARBA:ARBA00013204};
GN Name=budA {ECO:0000313|EMBL:AEB67188.1};
GN OrderedLocusNames=MCON_0316 {ECO:0000313|EMBL:AEB67188.1};
OS Methanothrix soehngenii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC
OS 103675 / OCM 69 / GP-6) (Methanosaeta concilii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=990316 {ECO:0000313|EMBL:AEB67188.1, ECO:0000313|Proteomes:UP000007807};
RN [1] {ECO:0000313|EMBL:AEB67188.1, ECO:0000313|Proteomes:UP000007807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6
RC {ECO:0000313|Proteomes:UP000007807};
RX PubMed=21571998; DOI=10.1128/JB.05031-11;
RA Barber R.D., Zhang L., Harnack M., Olson M.V., Kaul R., Ingram-Smith C.,
RA Smith K.S.;
RT "Complete genome sequence of Methanosaeta concilii, a specialist in
RT aceticlastic methanogenesis.";
RL J. Bacteriol. 193:3668-3669(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2;
CC Xref=Rhea:RHEA:21580, ChEBI:CHEBI:15378, ChEBI:CHEBI:15686,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:58476; EC=4.1.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001784};
CC -!- PATHWAY: Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-
CC butane-2,3-diol from pyruvate: step 2/3.
CC {ECO:0000256|ARBA:ARBA00005170}.
CC -!- SIMILARITY: Belongs to the alpha-acetolactate decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00007106}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002565; AEB67188.1; -; Genomic_DNA.
DR RefSeq; WP_013718250.1; NC_015416.1.
DR AlphaFoldDB; F4BVC0; -.
DR STRING; 990316.MCON_0316; -.
DR GeneID; 10460084; -.
DR KEGG; mcj:MCON_0316; -.
DR HOGENOM; CLU_072561_0_0_2; -.
DR InParanoid; F4BVC0; -.
DR OrthoDB; 81038at2157; -.
DR UniPathway; UPA00626; UER00678.
DR Proteomes; UP000007807; Chromosome.
DR GO; GO:0047605; F:acetolactate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0045151; P:acetoin biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd17299; acetolactate_decarboxylase; 1.
DR InterPro; IPR005128; Acetolactate_a_deCO2ase.
DR NCBIfam; TIGR01252; acetolac_decarb; 1.
DR PANTHER; PTHR35524; ALPHA-ACETOLACTATE DECARBOXYLASE; 1.
DR PANTHER; PTHR35524:SF1; ALPHA-ACETOLACTATE DECARBOXYLASE; 1.
DR Pfam; PF03306; AAL_decarboxy; 1.
DR PIRSF; PIRSF001332; Acetolac_decarb; 1.
DR SUPFAM; SSF117856; AF0104/ALDC/Ptd012-like; 1.
PE 3: Inferred from homology;
KW Acetoin biosynthesis {ECO:0000256|ARBA:ARBA00023061};
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:AEB67188.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007807}.
FT REGION 247..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..267
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 267 AA; 29682 MW; 7A588D85978CA572 CRC64;
MSDIKIAFDR AYAAIAILFL MMAQGSLAEE DDSLYQISTI GALMQGVYDG TMTFGELGER
GDFGLGTVQA LDGEMVAVDG RFYQVKSDGV AYSLSDSMIT PFSVVTFFDA EETINLGGRY
NLSELQGYLD NSLESDNLFY AIRIDGTFDY VKTRSVPAQE KPYPPLEEAI KGQEIFEFHD
VEGTVVGFRC PDYVEGVNVP GYHLHFITLD RKAGGHLLDL EIEDASAKVD SISGFEMDLP
ENKQFYQADL SDSQEEELER IESNPRE
//
