ID F4BYS2_METSG Unreviewed; 662 AA.
AC F4BYS2;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Peptidase C1A, papain, putative {ECO:0000313|EMBL:AEB67699.1};
GN OrderedLocusNames=MCON_0933 {ECO:0000313|EMBL:AEB67699.1};
OS Methanothrix soehngenii (strain ATCC 5969 / DSM 3671 / JCM 10134 / NBRC
OS 103675 / OCM 69 / GP-6) (Methanosaeta concilii).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanotrichales; Methanotrichaceae; Methanothrix.
OX NCBI_TaxID=990316 {ECO:0000313|EMBL:AEB67699.1, ECO:0000313|Proteomes:UP000007807};
RN [1] {ECO:0000313|EMBL:AEB67699.1, ECO:0000313|Proteomes:UP000007807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 5969 / DSM 3671 / JCM 10134 / NBRC 103675 / OCM 69 / GP-6
RC {ECO:0000313|Proteomes:UP000007807};
RX PubMed=21571998; DOI=10.1128/JB.05031-11;
RA Barber R.D., Zhang L., Harnack M., Olson M.V., Kaul R., Ingram-Smith C.,
RA Smith K.S.;
RT "Complete genome sequence of Methanosaeta concilii, a specialist in
RT aceticlastic methanogenesis.";
RL J. Bacteriol. 193:3668-3669(2011).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; CP002565; AEB67699.1; -; Genomic_DNA.
DR RefSeq; WP_013718753.1; NC_015416.1.
DR AlphaFoldDB; F4BYS2; -.
DR STRING; 990316.MCON_0933; -.
DR GeneID; 25395085; -.
DR KEGG; mcj:MCON_0933; -.
DR HOGENOM; CLU_414272_0_0_2; -.
DR InParanoid; F4BYS2; -.
DR OrthoDB; 137612at2157; -.
DR Proteomes; UP000007807; Chromosome.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR025193; DUF4114.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR025661; Pept_asp_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF642; PRO-CATHEPSIN H; 1.
DR Pfam; PF13448; DUF4114; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00640; THIOL_PROTEASE_ASN; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000007807}.
FT DOMAIN 69..279
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 662 AA; 74865 MW; EB56473E8A60854A CRC64;
MDEIKEIRSR IKGMNLTWTA GETAVSELAT DEKMHYLGLV VPEDEKAMIL QMAERDRSLA
AKSGSVSIYP TQWDWRDVSG NDWTTPIKDQ RQCGSCVAFA TVAAIESNLE IFKRDPSLDP
DLSEADLFFR GCGDCCGRGW YFTPALRFAQ SSGVPDEACN PYQGDKTGSC PDRDKRVVKI
ESWTTITNSS QAKEWLSQRG PLIGGLSVYE DFFYYEKGVY KTAYGGYMGD HAVCVVGFDD
AKGCWICKNS WGQGWGESGW FKIAYGECGM GSQFAFYGVQ FTADDDLIMP KSGRVIVRFT
GKSTTLEDEI WLYRPEEKLI FRAVDSDLGK IHDLGAFPAG TRLTFALKTS AGHIFYSDQL
LNDDVCDHVN KTGIGTYKWQ LNWEDLYGLG EKDYNDVSME IEIISATSED LVMPKEGRVF
ATLKQRHAAT KEEFRLSSPE NRLIFTLDSP MGKAIDLGKY PEGASLTFAF KTLEGYTYYT
DQVKNPDFLS HVRKLPTGYN KWELRWEKSY GMRLKSYKDL TAEIIVAPIV REDVILEKDS
HVVARLVSKN TPNHNQFWLY KPEKKLIFDS IQGNVGKSFE VGDYPTGTRL IFALQTQDGA
FFYTDSGLNE DGKSHVLRLK LGSNKCQLRW EDLYGLKDTD YNDLVVEIKM DPKQDPKKRV
TG
//
