ID F4CNS2_PSEUX Unreviewed; 353 AA.
AC F4CNS2;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=O-demethylpuromycin O-methyltransferase {ECO:0000313|EMBL:AEA22534.1};
DE EC=2.1.1.38 {ECO:0000313|EMBL:AEA22534.1};
GN OrderedLocusNames=Psed_0259 {ECO:0000313|EMBL:AEA22534.1};
OS Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / JCM 13855 /
OS CB1190).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Pseudonocardia.
OX NCBI_TaxID=675635 {ECO:0000313|EMBL:AEA22534.1, ECO:0000313|Proteomes:UP000007809};
RN [1] {ECO:0000313|EMBL:AEA22534.1, ECO:0000313|Proteomes:UP000007809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55486 / DSM 44775 / JCM 13855 / CB1190
RC {ECO:0000313|Proteomes:UP000007809};
RX PubMed=21725009; DOI=10.1128/JB.00415-11;
RA Sales C.M., Mahendra S., Grostern A., Parales R.E., Goodwin L.A., Woyke T.,
RA Nolan M., Lapidus A., Chertkov O., Ovchinnikova G., Sczyrba A.,
RA Alvarez-Cohen L.;
RT "Genome sequence of the 1,4-dioxane-degrading Pseudonocardia dioxanivorans
RT strain CB1190.";
RL J. Bacteriol. 193:4549-4550(2011).
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DR EMBL; CP002593; AEA22534.1; -; Genomic_DNA.
DR RefSeq; WP_013672475.1; NC_015312.1.
DR AlphaFoldDB; F4CNS2; -.
DR KEGG; pdx:Psed_0259; -.
DR eggNOG; COG2813; Bacteria.
DR HOGENOM; CLU_005533_12_0_11; -.
DR OrthoDB; 3804952at2; -.
DR Proteomes; UP000007809; Chromosome.
DR GO; GO:0030739; F:O-demethylpuromycin O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.287.1350; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:AEA22534.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007809};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:AEA22534.1}.
FT DOMAIN 15..86
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 114..324
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 250
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 353 AA; 37410 MW; 1E93B1E14A24333A CRC64;
MSETVSDSRA DAARLLEIVN SAWMPQALRA AAELGVPDLL ADGPRTAADV AEATGAHAPS
LHRLLRALVT IDVLTEDGEG GFALTPMGGL LRADVDGTVR SWAIYQGRDV WDEWGLMPEA
VRTGRSGREI AHGAGGFAPL RDDPRRAATF NSAMAELTRL SARAVVAGHD FGRYRRVADI
GGGYGELLGT ILRAHPGSTG ILFDLPHAVD AAAGHLDGMG VRDRCEIVSG SFFEEVPTGA
DLYVLKSVLH DWDDDRAAEI LAVVRRAIGP GARLLLVERL MPDRMRAVPE HRLLARADMN
MLVAHAAPER TEGQWRALLG SAGFDVVAVT PIPGAATAIE AVPAVGGVTG HVR
//
