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Database: UniProt
Entry: F4F486_VERMA
LinkDB: F4F486_VERMA
Original site: F4F486_VERMA 
ID   F4F486_VERMA            Unreviewed;       318 AA.
AC   F4F486;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   11-DEC-2019, entry version 38.
DE   RecName: Full=Prephenate dehydratase {ECO:0000256|RuleBase:RU361254};
DE            Short=PDT {ECO:0000256|RuleBase:RU361254};
DE            EC=4.2.1.51 {ECO:0000256|RuleBase:RU361254};
GN   Name=pheA {ECO:0000256|RuleBase:RU361254};
GN   OrderedLocusNames=VAB18032_04085 {ECO:0000313|EMBL:AEB47899.1};
OS   Verrucosispora maris (strain AB-18-032).
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Verrucosispora.
OX   NCBI_TaxID=263358 {ECO:0000313|EMBL:AEB47899.1, ECO:0000313|Proteomes:UP000008308};
RN   [1] {ECO:0000313|EMBL:AEB47899.1, ECO:0000313|Proteomes:UP000008308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB-18-032 {ECO:0000313|EMBL:AEB47899.1,
RC   ECO:0000313|Proteomes:UP000008308};
RX   PubMed=21551311; DOI=10.1128/JB.05041-11;
RA   Roh H., Uguru G.C., Ko H.J., Kim S., Kim B.Y., Goodfellow M., Bull A.T.,
RA   Kim K.H., Bibb M.J., Choi I.G., Stach J.E.;
RT   "Genome sequence of the abyssomicin- and proximicin-producing marine
RT   actinomycete Verrucosispora maris AB-18-032.";
RL   J. Bacteriol. 193:3391-3392(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC         Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC         Evidence={ECO:0000256|RuleBase:RU361254};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC       phenylpyruvate from prephenate: step 1/1.
CC       {ECO:0000256|RuleBase:RU361254}.
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DR   EMBL; CP002638; AEB47899.1; -; Genomic_DNA.
DR   RefSeq; WP_013736531.1; NC_015434.1.
DR   STRING; 263358.VAB18032_04085; -.
DR   EnsemblBacteria; AEB47899; AEB47899; VAB18032_04085.
DR   KEGG; vma:VAB18032_04085; -.
DR   eggNOG; ENOG4105CQC; Bacteria.
DR   eggNOG; COG0077; LUCA.
DR   KO; K04518; -.
DR   OMA; REVMSAC; -.
DR   OrthoDB; 1280729at2; -.
DR   UniPathway; UPA00121; UER00345.
DR   Proteomes; UP000008308; Chromosome.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR008242; Chor_mutase/pphenate_deHydtase.
DR   InterPro; IPR001086; Preph_deHydtase.
DR   InterPro; IPR018528; Preph_deHydtase_CS.
DR   Pfam; PF00800; PDT; 1.
DR   PIRSF; PIRSF001500; Chor_mut_pdt_Ppr; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00858; PREPHENATE_DEHYDR_2; 1.
DR   PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE   4: Predicted;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Aromatic amino acid biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Lyase {ECO:0000256|RuleBase:RU361254};
KW   Phenylalanine biosynthesis {ECO:0000256|RuleBase:RU361254};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008308}.
FT   DOMAIN          8..186
FT                   /note="Prephenate dehydratase"
FT                   /evidence="ECO:0000259|PROSITE:PS51171"
FT   DOMAIN          201..278
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
FT   SITE            179
FT                   /note="Essential for prephenate dehydratase activity"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001500-2"
SQ   SEQUENCE   318 AA;  33147 MW;  87343CA694F31D5F CRC64;
     MPGTPPTRFA FLGPEGTFAE QALRTLPAAE RGTRTPARSV GEALDAVRAG DADAALVPLE
     NSIGGAVGVT LDELAEGEPL VITREVILPV EFVLGARAGT QLSAVRTVAA HPQASTQCRG
     WLRTYLPDAT VIDVLSNGSA AAGAATGEYD AAICAPVGAT RHRLAVLADK IADHPDAVTR
     FALVARPGPP PPPTGDDVTT LAVYIAHDRV GALLSVLMEL AVRGVNLSRI ESRPTGKALG
     EYVFFLDCTG HVADVRLGEA LQGLRRVCAD VRFLGSYPRH RWSGAEGEQP VPAPAGLSDA
     DYADAAAWLA RLRAGELS
//
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