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Database: UniProt
Entry: F4F738_VERMA
LinkDB: F4F738_VERMA
Original site: F4F738_VERMA 
ID   F4F738_VERMA            Unreviewed;       369 AA.
AC   F4F738;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   08-MAY-2019, entry version 41.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   OrderedLocusNames=VAB18032_29156 {ECO:0000313|EMBL:AEB46902.1};
OS   Verrucosispora maris (strain AB-18-032).
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Verrucosispora.
OX   NCBI_TaxID=263358 {ECO:0000313|EMBL:AEB46902.1, ECO:0000313|Proteomes:UP000008308};
RN   [1] {ECO:0000313|EMBL:AEB46902.1, ECO:0000313|Proteomes:UP000008308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AB-18-032 {ECO:0000313|EMBL:AEB46902.1,
RC   ECO:0000313|Proteomes:UP000008308};
RX   PubMed=21551311; DOI=10.1128/JB.05041-11;
RA   Roh H., Uguru G.C., Ko H.J., Kim S., Kim B.Y., Goodfellow M.,
RA   Bull A.T., Kim K.H., Bibb M.J., Choi I.G., Stach J.E.;
RT   "Genome sequence of the abyssomicin- and proximicin-producing marine
RT   actinomycete Verrucosispora maris AB-18-032.";
RL   J. Bacteriol. 193:3391-3392(2011).
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP002638; AEB46902.1; -; Genomic_DNA.
DR   STRING; 263358.VAB18032_29156; -.
DR   EnsemblBacteria; AEB46902; AEB46902; VAB18032_29156.
DR   KEGG; vma:VAB18032_29156; -.
DR   eggNOG; ENOG4105E99; Bacteria.
DR   eggNOG; COG0722; LUCA.
DR   KO; K01626; -.
DR   OMA; YDINTGL; -.
DR   BioCyc; VMAR263358:GI1P-4919-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000008308; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008308};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008308};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156, ECO:0000313|EMBL:AEB46902.1}.
FT   DOMAIN       48    343       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   369 AA;  39053 MW;  F94D0D93534E3BFD CRC64;
     MTTPDNRRVI DQRIDRVVPL TTPALLHHEL PLEDDLASAV VAGRRTAAQV LDRIDDRLLV
     VVGPCSVHDP AAALEYAHRL REAADRVADD LLVVMRVYFE KPRSTVGWKG LINDPGLDGS
     GDVNAGLRLA RALLLDVLRL GLPVGCEFLD PITPQYIADT VAWGAIGART VESQVHRQLA
     SGLSMPIGMK NRPDGSIATA VDAIRAAGVP HVFPGIDVSG TPAIMHTRGN ADGHLVLRGG
     GGRPNYDAAS VAGALELLRA AGLPERLVVD ASHANSGKDH RNQPAVVADV AGQIAAGQRG
     IVGIMLESFL VPGRQDLDPT RELTYGQSIT DACIGWDTTD EVLTELAAAV RARRATRSSA
     DPHSLPAPA
//
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