ID   F4GDC0_ALIDK            Unreviewed;       724 AA.
AC   F4GDC0;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=HAD-superfamily hydrolase, subfamily IA, variant 3 {ECO:0000313|EMBL:AEB85949.1};
GN   OrderedLocusNames=Alide2_3624 {ECO:0000313|EMBL:AEB85949.1};
OS   Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Alicycliphilus.
OX   NCBI_TaxID=596154 {ECO:0000313|EMBL:AEB85949.1, ECO:0000313|Proteomes:UP000007938};
RN   [1] {ECO:0000313|EMBL:AEB85949.1, ECO:0000313|Proteomes:UP000007938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14773 / CIP 107495 / K601
RC   {ECO:0000313|Proteomes:UP000007938};
RX   PubMed=21742888; DOI=10.1128/JB.00365-11;
RA   Oosterkamp M.J., Veuskens T., Plugge C.M., Langenhoff A.A., Gerritse J.,
RA   van Berkel W.J., Pieper D.H., Junca H., Goodwin L.A., Daligault H.E.,
RA   Bruce D.C., Detter J.C., Tapia R., Han C.S., Land M.L., Hauser L.J.,
RA   Smidt H., Stams A.J.;
RT   "Genome Sequences of Alicycliphilus denitrificans Strains BC and K601T.";
RL   J. Bacteriol. 193:5028-5029(2011).
RN   [2] {ECO:0000313|EMBL:AEB85949.1, ECO:0000313|Proteomes:UP000007938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14773 / CIP 107495 / K601
RC   {ECO:0000313|Proteomes:UP000007938};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA   Peters L., Zeytun A., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Oosterkamp M.,
RA   Pieper D., van Berkel W., Langenhoff A., Smidt H., Stams A., Woyke T.;
RT   "Complete sequence of chromosome of Alicycliphilus denitrificans K601.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002657; AEB85949.1; -; Genomic_DNA.
DR   RefSeq; WP_013722809.1; NC_015422.1.
DR   AlphaFoldDB; F4GDC0; -.
DR   STRING; 596154.Alide2_3624; -.
DR   KEGG; adk:Alide2_3624; -.
DR   eggNOG; COG0246; Bacteria.
DR   eggNOG; COG0637; Bacteria.
DR   HOGENOM; CLU_024616_0_0_4; -.
DR   OrthoDB; 5293434at2; -.
DR   Proteomes; UP000007938; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006439; HAD-SF_hydro_IA.
DR   InterPro; IPR041492; HAD_2.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR023198; PGP-like_dom2.
DR   NCBIfam; TIGR01509; HAD-SF-IA-v3; 1.
DR   PANTHER; PTHR18901; 2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2; 1.
DR   PANTHER; PTHR18901:SF38; PSEUDOURIDINE-5'-PHOSPHATASE; 1.
DR   Pfam; PF13419; HAD_2; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00413; HADHALOGNASE.
DR   SFLD; SFLDG01129; C1.5:_HAD__Beta-PGM__Phosphata; 1.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:AEB85949.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007938}.
FT   DOMAIN          508..643
FT                   /note="Mannitol dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08125"
SQ   SEQUENCE   724 AA;  78359 MW;  05B45C0418A2A471 CRC64;
     MLQFQGKTID TAIFDMDGTM FDTERLRFQT LSQASEELFG KPFTEPVLLG SLGLSATKAE
     ALAKQHYGQD FPYAAIRRRA DELELAHVRT QGVPIKPGLL PVLERLRKSG LKMAVATSSR
     RAIAEEYLIN ANIYKYFDLC VCGDEVVQGK PHPEIFVRAA EALNSQPAQC LMFEDSENGV
     RSAADAGGVV ILVEDIQMPP PAVARRAFGV YGGLSEFLQD LAACTPKMSM PAVTEPFPQA
     VNLLKAGIHG FGAMGGGYLA QVFSHWDGYT RPCEIIASTG NALLREAIDA FGKFSVRYGS
     LAFDQTIEQL RVIDAADTDA VAGMYRDCEI VALCVPEQAV AAQAGVIAQG LAERFAAHGR
     ELTVLVVLNK VGGAEFVRAQ VEAALLQRVA SKVCQRILER TSFSETVVTR IVSKLTEDAL
     VRQLRIKSEL YKKNVVAVRE SSPHVGDWAE ALPGDTAEVV APHVSTLRDA GEPASALAPL
     HLILFNSETD MPLYVQQGSD LLEHLRQIDT VADIAVIQLL KNRLWNGTHA IVAWYAALLG
     YPSIGHAMGD ARVQALMDQL LDAELAPALA AQFPELRTRL AEFIATFRNR CAHAFKDPCE
     RVGRDPLRKL QRGERVLGSL AMAAAQGVAA PALAFGAALA VHYALHHPPA AEEDECRTIR
     ALYARREALQ DVLAWRGEYH GAPFDGLDPV ADAALLAAVQ LPFDGLQAGG LDYCWESAAE
     AGVG
//