ID F4IF00_ARATH Unreviewed; 1163 AA.
AC F4IF00;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:AEE35383.1};
GN OrderedLocusNames=At1g72860 {ECO:0000313|EMBL:AEE35383.1};
GN ORFNames=F3N23.6 {ECO:0000313|EMBL:AEE35383.1}, F3N23_6
GN {ECO:0000313|EMBL:AEE35383.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEE35383.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AEE35383.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
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DR EMBL; CP002684; AEE35383.1; -; Genomic_DNA.
DR RefSeq; NP_177429.2; NM_105944.2.
DR AlphaFoldDB; F4IF00; -.
DR SMR; F4IF00; -.
DR PaxDb; 3702-AT1G72860-1; -.
DR ProteomicsDB; 218335; -.
DR EnsemblPlants; AT1G72860.1; AT1G72860.1; AT1G72860.
DR GeneID; 843617; -.
DR Gramene; AT1G72860.1; AT1G72860.1; AT1G72860.
DR TAIR; AT1G72860; -.
DR HOGENOM; CLU_001561_0_2_1; -.
DR OMA; IYTERFS; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4IF00; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF600; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 635..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..173
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 780..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1163 AA; 132529 MW; 84DC1029F632759B CRC64;
MASSSSSPIW KYDVFLSFRG EDTRKNIVSH LHKQLVDKGV VTFKDDKKLE LGDSISEEIS
RAIQNSTYAL VILSENYASS SWCLDELRMV MDLHLKNKIK VVPIFYGVDP SHVRHQTGSF
TFDKYQDSKM PNKVTTWREA LTQIASLAGK DFETCEDEAS MIEEIVKDIS KKLLIMQPVD
FSDIVGMNAH MERLSPLLSM DSENEVRMIG IWGMGGIGKT TIAKCLFDQF SQGFPARCFL
ENVSKIYRKG GVSSLAEKFL STTLGLSKKK MKGSGVKLGP QEIKARFGCR KVFVVLDNVD
DMRQMHAFAQ ESSWFGPGSR IIITTRDKGL LNTYGVRTVY EVKCMDNDAA LQLFNQLAFK
GALPPSELYE KLSIRASWLA QGLPVAIEAY GLFFRRMTSL KEWDDALCRF IEAPDESVME
ILKISYDGLE ETDKNVFLHV ACLFNGEPLR RATTLLDDGV LQGCLGLKIL AEKSLIEITA
SGYIKMHNLV DQTARAIVNQ ESMQRRHGRG VLWNPYEIYE LLKRNTTSEP TNCMALHMCD
MVYALHLGGY TAYHDTLKFL KIYKHSNHIK SKLLFSGDDT NLLSSRLRLL HWDAFPLTTF
PCRFQPQDLV EIILHRSNLT SFWKETVVKA LNRSMLITMY LLVLNILAIF LFFVEYAQGM
PNLRRLDLSD SENLEQLPDL SMAVNLEELI TQGCKRLKKI PESISYLTRL TTLDVSYCEE
LASYITIREL NRSGRQIALY FSGKEVETRS IANLSIGGNI HIQMFWLDGN VDHLSFTTEQ
QGPDKLTKKE KQQAPGELTK REQQQEPRKK TILCGFGSLM RKGRKVKATS EFLDHEWMMQ
RDQLAPDNQQ ALEFSTRTRQ ALQFLPEFHG QESVKKAQGK SQPTSKFHGF TSVDISRFRY
SSDGASFLCF SLSMFPCVKE LILINLNIKV IPDDVCGLKF LEKLDWSGND FETLPETMNQ
LPRLKYASFR NCCRLKALPA LVQLETIKLS GCINLQSLLE LSYAEQDCGR FQWLELWVDG
CKSIRSILDQ LRHFIKLSYL DLSSHEFEKL PSSIEVLSSL RTLCLNKCKK LKSIEGLPLC
LKSLYAHGCE ILETVSLPLN HSVKHLDLSH CFGLKRDEHL IAQFLNEGEN EEVCFQLILP
LLHCKQPELD HSPSFFLFVV VLE
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