ID F4JHA4_ARATH Unreviewed; 816 AA.
AC F4JHA4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=GTP diphosphokinase {ECO:0000256|ARBA:ARBA00013251};
DE EC=2.7.6.5 {ECO:0000256|ARBA:ARBA00013251};
GN Name=RSH1 {ECO:0000313|EMBL:AEE82146.1, ECO:0000313|TAIR:AT4G02260};
GN Synonyms=AT-RSH1 {ECO:0000313|EMBL:AEE82146.1}, ATRSH1
GN {ECO:0000313|EMBL:AEE82146.1}, RELA-SPOT HOMOLOG 1
GN {ECO:0000313|EMBL:AEE82146.1}, RELA/SPOT HOMOLOG 1
GN {ECO:0000313|EMBL:AEE82146.1}, RELA/SPOT homolog 1
GN {ECO:0000313|EMBL:AEE82146.1};
GN OrderedLocusNames=At4g02260 {ECO:0000313|Araport:AT4G02260,
GN ECO:0000313|EMBL:AEE82146.1};
GN ORFNames=T2H3.10 {ECO:0000313|EMBL:AEE82146.1}, T2H3_10
GN {ECO:0000313|EMBL:AEE82146.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEE82146.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AEE82146.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=10617198; DOI=10.1038/47134;
RG EU;
RG CSHL and WU Arabidopsis Sequencing Project;
RA Mayer K., Schuller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Dusterhoft A., Stiekema W., Entian K.D., Terryn N., Harris B., Ansorge W.,
RA Brandt P., Grivell L., Rieger M., Weichselgartner M., de Simone V.,
RA Obermaier B., Mache R., Muller M., Kreis M., Delseny M., Puigdomenech P.,
RA Watson M., Schmidtheini T., Reichert B., Portatelle D., Perez-Alonso M.,
RA Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H.,
RA Ridley P., Langham S.A., McCullagh B., Bilham L., Robben J.,
RA Van der Schueren J., Grymonprez B., Chuang Y.J., Vandenbussche F.,
RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E.,
RA Brandt A., Peters S., van Staveren M., Dirske W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Kotter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., Van Montagu M., Rogers J.,
RA Cronin A., Quail M., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M.,
RA Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M.,
RA Benes V., Rechmann S., Borkova D., Blocker H., Scharfe M., Grimm M.,
RA Lohnert T.H., Dose S., de Haan M., Maarse A., Schafer M., Muller-Auer S.,
RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O.,
RA Quigley F., Clabauld G., Mundlein A., Felber R., Schnabl S., Hiller R.,
RA Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C.,
RA Montfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sehkon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L., Nelson J.,
RA Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J.,
RA Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffmann J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast
CC {ECO:0000256|ARBA:ARBA00004229}.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
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DR EMBL; CP002687; AEE82146.1; -; Genomic_DNA.
DR RefSeq; NP_974501.1; NM_202772.2.
DR AlphaFoldDB; F4JHA4; -.
DR SMR; F4JHA4; -.
DR ProteomicsDB; 197653; -.
DR EnsemblPlants; AT4G02260.3; AT4G02260.3; AT4G02260.
DR GeneID; 828096; -.
DR Gramene; AT4G02260.3; AT4G02260.3; AT4G02260.
DR Araport; AT4G02260; -.
DR TAIR; AT4G02260; RSH1.
DR HOGENOM; CLU_012300_5_0_1; -.
DR OMA; HSIQWFC; -.
DR PhylomeDB; F4JHA4; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JHA4; baseline and differential.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0008728; F:GTP diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR PANTHER; PTHR43061; GTP DIPHOSPHOKINASE RSH1, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR43061:SF1; GTP DIPHOSPHOKINASE RSH1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plastid {ECO:0000256|ARBA:ARBA00022640};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F4JHA4,
KW ECO:0007829|ProteomicsDB:F4JHA4};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Transferase {ECO:0000256|ARBA:ARBA00022777};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 172..279
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 562..625
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT REGION 710..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 91647 MW; FA75F6CA92B054F8 CRC64;
MTSASSMSVS VECVNICNLT KGDGNARSDC SALSCAWKAP RALTGFLAST AHPPVCSVYS
CGRNGRKSRM KACAWQRYEY EVGFSEAPYF VNVRNILKSR LSCGGHKRWE LYCVSAESSS
GASSDVTVET LWEDLFPSIS YLPRKELEFV QKGLKLAFEA HHGQKRRSGE PFIIHPVAVA
RILGELELDW ESIVAGLLHD TVEDTNFITF EKIEEEFGAT VRHIVEGETK VSKLGKLKCK
TESETIQDVK ADDLRQMFLA MTDEVRVIIV KLADRLHNMR TLCHMPPHKQ SSIAGETLQV
FAPLAKLLGM YSIKSELENL SFMYVSAEDY DRVTSRIANL YKEHEKELTE ANRILVKKIE
DDQFLDLVTV NTDVRSVCKE TYSIYKAALK SKGSINDYNQ IAQLRIVVKP KPSVGVGPLC
SPQQICYHVL GLVHEIWKPI PRTVKDYIAT PKPNGYQSLH TTVIPFLYES MFRLEVQIRT
EEMDLIAERG IAVYYNGKSL STGLVGNAVP LGRNSRGKTG CLNNADFALR VGWLNAIREW
QEEFVGNMSS REFVDTITRD LLGSRVFVFT PKGEIKNLPK GATVVDYAYL IHTEIGNKMV
AAKVNGNLVS PTHVLENAEV VEIVTYNALS SKSAFQRHKQ WLQHAKTRSA RHKIMRFLRE
QAAQCAAEIT QDQVNDFVAD SDSDVEDLTE DSRKSLQWWE KILVNVKQFQ SQDKSRDTTP
APQNGSVWAP KVNGKHNKAI KNSSSDEPEF LLPGDGIARI LPANIPAYKE VLPGLDSWRD
SKIATWHHLE GQSIEWLCVV SMDRKGMGIF VLFSHD
//
