ID RLT3_ARATH Reviewed; 1131 AA.
AC F4JRF5; Q9SU11;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Homeobox-DDT domain protein RLT3 {ECO:0000305};
DE AltName: Full=Protein RINGLET 3 {ECO:0000305};
GN Name=RLT3 {ECO:0000305};
GN OrderedLocusNames=At4g12750 {ECO:0000312|Araport:AT4G12750};
GN ORFNames=T20K18.100 {ECO:0000312|EMBL:CAB40992.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Transcriptional regulator required for the maintenance of the
CC plant vegetative phase. May prevent the early activation of the
CC vegetative-to-reproductive transition by regulating key genes that
CC contribute to flower timing. {ECO:0000250|UniProtKB:F4HY56}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB40992.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78317.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049640; CAB40992.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161534; CAB78317.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; T06633; T06633.
DR AlphaFoldDB; F4JRF5; -.
DR STRING; 3702.F4JRF5; -.
DR PaxDb; 3702-AT4G12750-1; -.
DR Araport; AT4G12750; -.
DR TAIR; AT4G12750; -.
DR eggNOG; ENOG502QSVY; Eukaryota.
DR HOGENOM; CLU_001241_1_0_1; -.
DR InParanoid; F4JRF5; -.
DR PRO; PR:F4JRF5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JRF5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR044977; RLT1-3.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR PANTHER; PTHR36968; HOMEOBOX-DDT DOMAIN PROTEIN RLT2; 1.
DR PANTHER; PTHR36968:SF8; HOMEOBOX-DDT DOMAIN PROTEIN RLT3 ISOFORM X1; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Flowering; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..1131
FT /note="Homeobox-DDT domain protein RLT3"
FT /id="PRO_0000435115"
FT DOMAIN 365..424
FT /note="DDT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00063"
FT DNA_BIND 2..56
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 239..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..264
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1131 AA; 127805 MW; 6EFB30D418211D56 CRC64;
MKRKSPLQVQ ALEGFYLEQM YPTPKEMEDL GKSLGLTLKE VRGWFKRRRS RGKGVKSMAN
DGLGAKNPQL YDRSLMRSST SSRCVGVAVE ERCIVGTRKA SCQNLLPSSH ILAKVFRKDG
PSLGSEFDHL PSGARKASWL GTSSVGQQKQ KVARKRKISE LMDHTSQDCI QENATVMKHG
IGKGLMTVWR VMNPNRRDVS PCVDLLDERA TLPQSSARNP PHQKKKQRQL ASILKQKLLQ
KRSTEKKRRS IHREAELNKD ETQREFKENC ELAADGEVFK ETCQTISTLV DDEELEMRER
HERGNPLTCS CHHPSSGSHG CFLCKGIAMR SSDSSLLFPD LLPKFPPNSV QMRMPFGLHP
WNSSPESVKK LFKVVHFLYT YSVTLDIGPF TLDEFTRAFH DKDSLLLGKI HLSLLKLLLL
DVETELERGS FSNLSISCKF LALLQSVESQ ILILDMWRNS LNSLTWTELL RQILVAAGYG
SLKCAVQSEE LSKERKLMKK YGLRLGTLKG ELFRMLNGQG NNGLKISELA DAPEVAVLNL
ATVPEERENS ICSTLASDIT LFEKISESTY RVRVNCFSED PDKSQSDSDD SGSVDDESDD
CSISSGDEIE HVSENPALRK VKCRKRRKHK SKMREVCSEI DESHPGEPWL LGLMEGEYSD
LSVEEKLDVF VALIDLLSSG STIRMEDLPR AVADCAPSIY SHGSGGKIKR SSSNQYSYPR
GSWVHGGELY GIKALSKSSD SHPVDSSSIV GAFAKLAGNR ANNVHPMQSV YLGSDRRFNR
YWLFLGTCNA NDPGHRCVFF ESSEDGHWEV INNKEALRAL LSVLDDRGRR EARLIESLEK
RESFLCQAML SRQVTQSETA HFTDIVREDS SSPVSDIDNN LCLNEIANDQ FSSQHAAIVF
EIGSKREKSL LWSLIQEFDD WIWANFNFNL NSVKHRRRSY LDSLTRCKSC HDLYWRDEKH
CKICHATFEV DIDLEERYAI HAATCMRKEE CDTFPDHKVL SSQLQSLKAA VYAIESAMPE
DALIGAWRKS AHRLWAKRLR RSSSVSEITQ VIGDFVGAIN EEWLWHCSDQ GQTLMGEIIN
CFPSMPQTTS AIALWLVKLD TLIAPYVEKA PPERDQPLCR TRNTSRRASK R
//
