ID F4JVE9_ARATH Unreviewed; 1008 AA.
AC F4JVE9;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:AEE83431.1};
GN Name=DL3225C {ECO:0000313|EMBL:AEE83431.1};
GN OrderedLocusNames=At4g14370 {ECO:0000313|Araport:AT4G14370,
GN ECO:0000313|EMBL:AEE83431.1};
GN ORFNames=FCAALL.185 {ECO:0000313|EMBL:AEE83431.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AEE83431.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AEE83431.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=10617198; DOI=10.1038/47134;
RG EU;
RG CSHL and WU Arabidopsis Sequencing Project;
RA Mayer K., Schuller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Dusterhoft A., Stiekema W., Entian K.D., Terryn N., Harris B., Ansorge W.,
RA Brandt P., Grivell L., Rieger M., Weichselgartner M., de Simone V.,
RA Obermaier B., Mache R., Muller M., Kreis M., Delseny M., Puigdomenech P.,
RA Watson M., Schmidtheini T., Reichert B., Portatelle D., Perez-Alonso M.,
RA Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H.,
RA Ridley P., Langham S.A., McCullagh B., Bilham L., Robben J.,
RA Van der Schueren J., Grymonprez B., Chuang Y.J., Vandenbussche F.,
RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E.,
RA Brandt A., Peters S., van Staveren M., Dirske W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Kotter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., Van Montagu M., Rogers J.,
RA Cronin A., Quail M., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M.,
RA Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M.,
RA Benes V., Rechmann S., Borkova D., Blocker H., Scharfe M., Grimm M.,
RA Lohnert T.H., Dose S., de Haan M., Maarse A., Schafer M., Muller-Auer S.,
RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O.,
RA Quigley F., Clabauld G., Mundlein A., Felber R., Schnabl S., Hiller R.,
RA Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C.,
RA Montfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sehkon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L., Nelson J.,
RA Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J.,
RA Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffmann J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
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DR EMBL; CP002687; AEE83431.1; -; Genomic_DNA.
DR RefSeq; NP_001319937.1; NM_001340924.1.
DR AlphaFoldDB; F4JVE9; -.
DR SMR; F4JVE9; -.
DR ProteomicsDB; 214260; -.
DR EnsemblPlants; AT4G14370.1; AT4G14370.1; AT4G14370.
DR GeneID; 827081; -.
DR Gramene; AT4G14370.1; AT4G14370.1; AT4G14370.
DR KEGG; ath:AT4G14370; -.
DR Araport; AT4G14370; -.
DR TAIR; AT4G14370; -.
DR HOGENOM; CLU_001561_0_1_1; -.
DR OMA; CESMERF; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JVE9; baseline and differential.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF574; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS)-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 1: Evidence at protein level;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F4JVE9,
KW ECO:0007829|ProteomicsDB:F4JVE9};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 1..133
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1008 AA; 115188 MW; B381920ECD8F84D9 CRC64;
MFDDQEIERS QTIAPALIKA IKESRISIIL LSKNYASSSW CLDELLEIVK CKEAMGQIVM
TVFYGVDPSD VRKQTGEFGR SFNETCSRST KEKRRKWSQA LNHVGNIAGE HFQNWDNESK
MIEKISRDIS NKLNSTISRD FDDMVGLEAH LEEMKYLLDL DYKDGAMIVG ICGPAGIGKT
TIARALYSLL LSSFQLSCFV ENLSGSDNRG LDEYGFKLRL QEQLLSKILN QNGMRIYHLG
AIQERLCDQK VLIVLDDVND LKQLEALANE TSWFGPGSRI IVTTEDKGLL EQHGINKTYH
VGFPSIEEAL EIFCIYAFRK SSPPDGFKKL TKRVTNVFDN LPLGLRVMGS SLRGKGEDEW
EALLDRLETS LDRNIEGALR VGYDSLQEEE QALFLHIAVF FNYNKDEHVI AMLADSNLDV
KQGLKILTNK SLVYRSTSGK IVMHKLLQQV GRKAIQRQEP WKRHILIDAH EICYVLENDT
DTRAALGISL DTSGINKVII SEGAFKRMRN LRFLSVYNTR YVKNDQVDIP EDLEFPPHLR
LLRWEAYPSN ALPTTFHPEY LVELDMKESQ LEKLWQGTQP LTNLKKMDLT RSSHLKELPD
LSNATNLERL ELSYCKSLVE IPSSFSELRK LETLVIHNCT KLEVVPTLIN LASLDFFNMH
GCFQLKKFPG ISTHISRLVI DDTLVEELPT SIILCTRLRT LMISGSGNFK TLTYLPLSLT
YLDLRCTGIE KIPDWIKDLH ELSFLHIGGC RNLKSLPQLP LSIRWLNACD CESLESVACV
SSLNSFVDLN FTNCFKLNQE TRRDLIQQSF FRSLRILPGR EVPETFNHQA KGNVLTIRPE
SDSQFSASSR FKACFVISPT RLITGRKRLI SLLCRLISKN GDSINEVYHC FSLPDQSPGT
QSEHLCLFHY DFHDRDRYFE VDSEILFEFS CTPSDAYEIV QCGVGTYGEE IEQISDWSNA
SEEIETENIS DDVNQYRDRH PCKSDKASKE ANVKGHKRKG FWSWLRRR
//
