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Database: UniProt
Entry: F4K1J4
LinkDB: F4K1J4
Original site: F4K1J4 
ID   ATXR7_ARATH             Reviewed;        1423 AA.
AC   F4K1J4; A9QA58; Q56XT6; Q945S7; Q9FIH7;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   13-FEB-2019, entry version 63.
DE   RecName: Full=Histone-lysine N-methyltransferase ATXR7 {ECO:0000305};
DE            EC=2.1.1.43 {ECO:0000305};
DE   AltName: Full=Protein SET DOMAIN GROUP 25 {ECO:0000303|PubMed:19726574};
DE   AltName: Full=Trithorax-related protein 7 {ECO:0000303|PubMed:19855050};
GN   Name=ATXR7 {ECO:0000303|PubMed:19855050};
GN   Synonyms=SDG25 {ECO:0000303|PubMed:19726574};
GN   OrderedLocusNames=At5g42400 {ECO:0000312|Araport:AT5G42400};
GN   ORFNames=MDH9.9 {ECO:0000312|EMBL:BAB10481.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19726574; DOI=10.1104/pp.109.143941;
RA   Berr A., Xu L., Gao J., Cognat V., Steinmetz A., Dong A., Shen W.H.;
RT   "SET DOMAIN GROUP25 encodes a histone methyltransferase and is
RT   involved in FLOWERING LOCUS C activation and repression of
RT   flowering.";
RL   Plant Physiol. 151:1476-1485(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA   Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VIII.
RT   Sequence features of the regions of 1,081,958 bp covered by seventeen
RT   physically assigned P1 and TAC clones.";
RL   DNA Res. 5:379-391(1998).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-513.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J.,
RA   Hayashizaki Y., Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1032-1290.
RX   PubMed=11691919; DOI=10.1093/nar/29.21.4319;
RA   Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K.,
RA   Assalkhou R., Schulz I., Reuter G., Aalen R.B.;
RT   "The Arabidopsis thaliana genome contains at least 29 active genes
RT   encoding SET domain proteins that can be assigned to four
RT   evolutionarily conserved classes.";
RL   Nucleic Acids Res. 29:4319-4333(2001).
RN   [6]
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=19855050; DOI=10.1105/tpc.109.070060;
RA   Tamada Y., Yun J.Y., Woo S.C., Amasino R.M.;
RT   "ARABIDOPSIS TRITHORAX-RELATED7 is required for methylation of lysine
RT   4 of histone H3 and for transcriptional activation of FLOWERING LOCUS
RT   C.";
RL   Plant Cell 21:3257-3269(2009).
RN   [7]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21799800; DOI=10.1371/journal.pone.0022241;
RA   Liu Y., Geyer R., van Zanten M., Carles A., Li Y., Horold A.,
RA   van Nocker S., Soppe W.J.;
RT   "Identification of the Arabidopsis REDUCED DORMANCY 2 gene uncovers a
RT   role for the polymerase associated factor 1 complex in seed
RT   dormancy.";
RL   PLoS ONE 6:E22241-E22241(2011).
CC   -!- FUNCTION: Histone methyltransferase involved in regulation of
CC       flowering time. Required for the expression of the flowering
CC       repressors FLC and MADS-box genes of the MAF family
CC       (PubMed:19726574, PubMed:19855050). Required for histone H3
CC       dimethylation on 'Lys-36' H3K36me2 at the FLC locus
CC       (PubMed:19726574). Required for histone H3 trimethylation on 'Lys-
CC       4' (H3K4me3) at the FLC locus. Prevents trimethylation on 'Lys-27'
CC       (H3K27me3) at the same locus (PubMed:19855050). Involved in the
CC       control of seed dormancy and germination (PubMed:21799800).
CC       {ECO:0000269|PubMed:19726574, ECO:0000269|PubMed:19855050,
CC       ECO:0000269|PubMed:21799800}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000305};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19726574}.
CC   -!- TISSUE SPECIFICITY: Expressed in the shoot and root apices,
CC       vascular tissues and mesophyll cells of rosette leaves.
CC       {ECO:0000269|PubMed:19855050}.
CC   -!- DISRUPTION PHENOTYPE: Early flowering (PubMed:19726574,
CC       PubMed:19855050). Reduced seed dormancy and increased germination
CC       rate of freshly harvested seeds (PubMed:21799800).
CC       {ECO:0000269|PubMed:19726574, ECO:0000269|PubMed:19855050,
CC       ECO:0000269|PubMed:21799800}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. TRX/MLL subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABV68922.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC       Sequence=BAB10481.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; EU014691; ABV68922.1; ALT_SEQ; mRNA.
DR   EMBL; AB016888; BAB10481.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK221587; BAD95095.1; -; mRNA.
DR   EMBL; AF408061; AAL01112.1; -; mRNA.
DR   RefSeq; NP_001318731.1; NM_001344444.1.
DR   RefSeq; NP_001330664.1; NM_001344445.1.
DR   RefSeq; NP_001330665.1; NM_001344446.1.
DR   RefSeq; NP_001330666.1; NM_001344449.1.
DR   RefSeq; NP_001330667.1; NM_001344450.1.
DR   RefSeq; NP_001330668.1; NM_001344447.1.
DR   RefSeq; NP_001330669.1; NM_001344448.1.
DR   RefSeq; NP_001330670.1; NM_001344451.1.
DR   UniGene; At.30177; -.
DR   ProteinModelPortal; F4K1J4; -.
DR   STRING; 3702.AT5G42400.1; -.
DR   PaxDb; F4K1J4; -.
DR   PRIDE; F4K1J4; -.
DR   GeneID; 834246; -.
DR   KEGG; ath:AT5G42400; -.
DR   Araport; AT5G42400; -.
DR   TAIR; locus:2162346; AT5G42400.
DR   eggNOG; KOG1080; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000176948; -.
DR   InParanoid; F4K1J4; -.
DR   OrthoDB; 875190at2759; -.
DR   PRO; PR:F4K1J4; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   Genevisible; F4K1J4; AT.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IEA:InterPro.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0010452; P:histone H3-K36 methylation; IDA:TAIR.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IGI:TAIR.
DR   GO; GO:0009909; P:regulation of flower development; IMP:TAIR.
DR   GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR   Gene3D; 3.30.1490.40; -; 2.
DR   InterPro; IPR003169; GYF.
DR   InterPro; IPR035445; GYF-like_dom_sf.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR037861; SETD1-like.
DR   PANTHER; PTHR22884:SF464; PTHR22884:SF464; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF55277; SSF55277; 2.
DR   PROSITE; PS50829; GYF; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Complete proteome; Flowering; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN         1   1423       Histone-lysine N-methyltransferase ATXR7.
FT                                /FTId=PRO_0000432765.
FT   DOMAIN      263    312       GYF. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00101}.
FT   DOMAIN     1266   1383       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   BINDING    1382   1382       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00190}.
FT   CONFLICT   1046   1046       A -> V (in Ref. 5; AAL01112).
FT                                {ECO:0000305}.
FT   CONFLICT   1124   1124       Q -> K (in Ref. 5; AAL01112).
FT                                {ECO:0000305}.
SQ   SEQUENCE   1423 AA;  158663 MW;  E0FC98122AF0697D CRC64;
     MVAVDSTFPS HGSSYSSRRK KVSALEPNYF GSMCMGVYSD DVSISAREVA QDYSCDSCGD
     LATVSSACCN FDELCGLDSA LEMGCRSNED CRAGQEASGS GIASGLDKSV PGYTMYASGW
     MYGNQQGQMC GPYTQQQLYD GLSTNFLPED LLVYPIINGY TANSVPLKYF KQFPDHVATG
     FAYLQNGIIS VAPSVTSFPP SSSNATVHQD EIQTEHATSA THLISHQTMP PQTSSNGSVL
     DQLTLNHEES NMLASFLSLG NEHACWFLVD GEGRNHGPHS ILELFSWQQH GYVSDAALIR
     DGENKLRPIT LASLIGVWRV KCGDANCDEP VTGVNFISEV SEELSVHLQS GIMKIARRAL
     LDEIISSVIS DFLKAKKSDE HLKSYPPTSA VESISSRVIN AEKSVVSNTE SAGCKNTMNE
     GGHSSIAAES SKYTKSVGSI ENFQTSCSAV CRTLHHHCMQ IMWNAVFYDT VATHSSCWRK
     NKIWFRSSDI STVNYCKGSH TKYSDKPESF ESFTCRVDSS SSKTAYSDEF DLATNGARVR
     GLSSDTYGTE SVIASISEHV ENELFLSLKT HLTDYTSILI KDGANNTTSS ARDGKMHEGS
     FREQYNLEGS SKKKNGLNVV PAKLRFSNDF SDSQRLLQEG ESSEQITSED IIANIFSTAL
     ETSDIPVNDE LDALAIHEPP PPGCESNINM PCLRYKYQPV RSKESIPEIK AYVSMALCRQ
     KLHNDVMRDW KSLFLKCYLN EFLASLKGSH QVSRKETLAL KKRKTVTRNK KLVQSNISNQ
     TAEKLRKPCV GASEKVLVKR SKKLSDSHSM KEVLKVDTPS IDLSVRKPSQ QKMRNTDRRD
     HCIIKDATKL HKEKVGKDAF SKVICDKSQD LEMEDEFDDA LLITRLRRIS RNKTKELREC
     RNAAKSCEEI SVTAEESEET VDCKDHEESL SNKPSQKVKK AHTSKLKRKN LSDARDEGTK
     SCNGAVKSFT EISGKEGDTE SLGLAISDKV SHQNLSKRRK SKIALFLFPG FENTSRKCFT
     KLLSPEDAAK NGQDMSNPTG NPPRLAEGKK FVEKSACSIS QKGRKSSQSS ILKRKHQLDE
     KISNVPSRRR LSLSSTDSED AVIKEDYDVR NEEKLPCHTS DKLQKGPNKL IRRRKPLAKH
     TTERSPIKDL SVDDGRPKPI ALKPLEKLSS KPSKKKLFLS IPKSDGCART SINGWHWHAW
     SLKASAEERA RVRGSSCVHM QHFGSKSSLT QNVLSARTNR AKLRNLLAAA DGADVLKMSQ
     LKARKKHLRF QQSKIHDWGL VALEPIEAED FVIEYVGELI RSSISEIRER QYEKMGIGSS
     YLFRLDDGYV LDATKRGGIA RFINHSCEPN CYTKIISVEG KKKIFIYAKR HIDAGEEISY
     NYKFPLEDDK IPCNCGAPNV YCFCEQVPWI AKLKRRTWFS RRN
//
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