ID F4K8S9_ARATH Unreviewed; 1507 AA.
AC F4K8S9;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Homeodomain-like transcriptional regulator {ECO:0000313|EMBL:AED95071.1};
GN Name=RLT2 {ECO:0000313|EMBL:AED95071.1, ECO:0000313|TAIR:AT5G44180};
GN Synonyms=MLN1.10 {ECO:0000313|EMBL:AED95071.1}, MLN1_10
GN {ECO:0000313|EMBL:AED95071.1}, RINGLET 2
GN {ECO:0000313|EMBL:AED95071.1};
GN OrderedLocusNames=At5g44180 {ECO:0000313|Araport:AT5G44180,
GN ECO:0000313|EMBL:AED95071.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AED95071.1, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AED95071.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130714; DOI=10.1038/35048507;
RG Kazusa DNA Research Institute;
RG Cold Spring Harbor and Washington University in St Louis Sequencing Consortium;
RG European Union Arabidopsis Genome Sequencing Consortium;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J.,
RA Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T., Entian K.D.,
RA Terryn N., Hartley N., Bent E., Johnson S., Langham S.A., McCullagh B.,
RA Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H.,
RA Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Lankhorst R.K., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S.,
RA Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J.,
RA Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K., Rudd S., Schoof H.,
RA Schueller C., Zaccaria P., Mewes H.W., Bevan M., Fransz P.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2] {ECO:0007829|PubMed:19376835}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [3] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR EMBL; CP002688; AED95071.1; -; Genomic_DNA.
DR RefSeq; NP_001190470.1; NM_001203541.1.
DR SMR; F4K8S9; -.
DR ProteomicsDB; 201351; -.
DR EnsemblPlants; AT5G44180.2; AT5G44180.2; AT5G44180.
DR GeneID; 834441; -.
DR Gramene; AT5G44180.2; AT5G44180.2; AT5G44180.
DR Araport; AT5G44180; -.
DR TAIR; AT5G44180; RLT2.
DR HOGENOM; CLU_001241_0_1_1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4K8S9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR007759; Asxl_HARE-HTH.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR044977; RLT1-3.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR PANTHER; PTHR36968; HOMEOBOX-DDT DOMAIN PROTEIN RLT2; 1.
DR PANTHER; PTHR36968:SF5; HOMEOBOX-DDT DOMAIN PROTEIN RLT2; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF05066; HARE-HTH; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51913; HTH_HARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F4K8S9,
KW ECO:0007829|ProteomicsDB:F4K8S9};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 15..75
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 514..573
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 696..765
FT /note="HTH HARE-type"
FT /evidence="ECO:0000259|PROSITE:PS51913"
FT DNA_BIND 17..76
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 795..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1368..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 314..443
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 796..813
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1327..1341
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1436..1450
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1507 AA; 169583 MW; 48272F707C875E40 CRC64;
MEGGSEKTTP EGCGGESKSK RKMKTAAQLE VLENTYSAEP YPSEAIRADL SVKLNLSDRQ
LQMWFCHRRL KERKSTTPSK RQRKELVTPT AMESWEPPVN AGDLVAGNEL DSRRAARGSG
GSGVTVVRRF NEPSSAEVRA IGYVEAQLGE RLRDNGPVLG MEFDPLPPGA FGMPIEMPSH
RKATRQAFET NIYVRSDVKP IKDHVRPIRE YQFIPELPSS RTDHSERVSP SHHFGVPLDG
SVMRVSAVSA GHRDDYKISP QIPNLNLATH QGKPGHVYSP NLVEYDSPYQ KSYMDTAAQV
HDDPFVKSER EVGNEDEDDD ALQLERHRKN EEARIAREVE AHEKRIRREL EKQDMLRRKR
EEQIRKEMER QDRERRKEEE RLLREKQREE ERYLKEQMRE LQRREKFLKK ETIRAEKMRQ
KEEMRKEKEV ARLKAANERA IARKIAKESM ELIEDERLEL MEVAALTKGL PSMLALDFET
LQNLDEYRDK QAIFPPTSVK LKKPFAVKPW NGSDENVANL LMVWRFLITF ADVLGLWPFT
LDEFAQAFHD YDPRLMGEIH IVLLKTIIKD IEGVVRTLST GVGANQNVAA NPGGGHPHVV
EGAYAWGFDI RSWRKNLNVF TWPEILRQLA LSAGLGPQLK KMNIRTVSVH DDNEANNSEN
VIFNLRKGVA AENAFAKMQE RGLSNPRRSR HRLTPGTVKF AAFHVLSLEG EKGLNILEVA
EKIQKSGLRD LTTSRTPEAS VAAALSRDTK LFERVAPSTY CVRASYRKDA GDAETIFAEA
RERIRAFKSG ITDVEDVDDA ERDEDSESDV GEDPEVDVNL KKEDPNPLKV ENLIGVEPLL
ENGKLDTVPM KTELGLPLTP SLPEEMKDEK RDDTLADQSL EDAVANGEDS ACFDESKLGE
QWVQGLVEGD YSNLSSEERL NALVALIGIA TEGNTIRIAL EERLEVASAL KKQMWGEVQL
DKRWKEESLI RANYLSYPTA KPGLNIATPA SGNQESSSAD VTPISSQDPV SLPQIDVNNV
IAGPSLQLQE NVPGVENLQY QQQQGYTADR ERLRAQLKAY VGYKAEELYV YRSLPLGQDR
RRNRYWRFSA SASRNDPGCG RIFVELQDGR WRLIDSEEAS LPPEGLEAFW TENLRKSWGM
KLLSSSSHED LYQVLTTLEA ALKRDFLSSN FETTSELLGL QEGALASDLT CGVNVLPWIP
KTAGGVALRL FDFDSSIVYT PDQNNDPLKD KESEDFVGLE TNILRNLHEK DVMETPVQVA
AYKQEENWTD PGLGGVSSSG RGGRPPRGRG RPRARGNGKK PAVSVKPPRG AANSNGETML
RPRAQPRGGR KNGRRSGTKG RKRPTQGTLG ICNEVGGGRR VKEVAVTAKT SLPDNDDDWI
ETPELQDDDG EASSSGRSFQ YEDYDDDDVM APIDDFDGGG ESSKLVGRGE FSLHSDDEYE
EEEEEEEDMN MKMDVNVVDD EDEDYINEDS YGRKQHGISI SNDAATRKRF NKFEDPDLTS
SSSSDFQ
//
