ID F4KII0_ARATH Unreviewed; 3484 AA.
AC F4KII0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Vacuolar protein sorting-associated protein, putative (DUF1162) {ECO:0000313|EMBL:AED93353.2};
GN Name=SHBY {ECO:0000313|EMBL:AED93353.2, ECO:0000313|TAIR:AT5G24740};
GN Synonyms=SHRUBBY {ECO:0000313|EMBL:AED93353.2};
GN OrderedLocusNames=At5g24740 {ECO:0000313|Araport:AT5G24740,
GN ECO:0000313|EMBL:AED93353.2};
GN ORFNames=T4C12.10 {ECO:0000313|EMBL:AED93353.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:AED93353.2, ECO:0000313|Proteomes:UP000006548};
RN [1] {ECO:0000313|EMBL:AED93353.2, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130714; DOI=10.1038/35048507;
RG Kazusa DNA Research Institute;
RG Cold Spring Harbor and Washington University in St Louis Sequencing Consortium;
RG European Union Arabidopsis Genome Sequencing Consortium;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J.,
RA Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T., Entian K.D.,
RA Terryn N., Hartley N., Bent E., Johnson S., Langham S.A., McCullagh B.,
RA Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H.,
RA Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Lankhorst R.K., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S.,
RA Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J.,
RA Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K., Rudd S., Schoof H.,
RA Schueller C., Zaccaria P., Mewes H.W., Bevan M., Fransz P.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; CP002688; AED93353.2; -; Genomic_DNA.
DR RefSeq; NP_001318641.1; NM_001343894.1.
DR ProteomicsDB; 194135; -.
DR EnsemblPlants; AT5G24740.2; AT5G24740.2; AT5G24740.
DR GeneID; 832543; -.
DR Gramene; AT5G24740.2; AT5G24740.2; AT5G24740.
DR KEGG; ath:AT5G24740; -.
DR Araport; AT5G24740; -.
DR TAIR; AT5G24740; SHBY.
DR HOGENOM; CLU_028319_0_0_1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KII0; baseline and differential.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 2.
PE 1: Evidence at protein level;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Proteomics identification {ECO:0007829|PeptideAtlas:F4KII0,
KW ECO:0007829|ProteomicsDB:F4KII0};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 10..118
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..369
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 602..822
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 2070..2360
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2487..2721
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 3038..3206
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3298..3366
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 427..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3484 AA; 389269 MW; F533E4B38A4A0B91 CRC64;
MLEGYVQGFV NLLLGYLGRY IKDIQKDQLK ISLWNGEVLL ENVELNPEAF EYLQLPIALK
QGRVGKLSIK IPWKKLHRDP VTIMIEDVFI CASQRNDQEW SSDVVEKREF AGKKAKLASA
ELAKLSRRVF DNPGGNSYMS YITAKILDSV QVSIKNFHIL YSDAQPESGQ VVLGLRFSSL
TVTKQNSVGP SVGRVRGGQV NILVEVEGLE IYCDMYEGNM DFPSVNEKIG FDNWCQSRLQ
SNRFGYLLKP VHVSVTLLVN RSGELYDDLP QYSISAELTD VVVTLNEFQL QQILILLDYL
QTSQLRERYG RYRPCSTSLS RKPPGWQKLW WHYAQNSVLS DVRKKLWKTS WRFLEQRMRI
RRRYINFYKI KLDLLLREQS IDKSIRLGLE ELEKKSDIDD ILSYRSAAEG EMQEACSELT
VNMGATGATR SEKEQSAPEK EPSDDPTLNK SRGWLNWLSR GMLGAGGTED SSQFSGVVSD
EVVKDIHKAT KFYPLSSSPR NTSATGKICT CSIRLNVRKF SATLQHISGS SSQVITELDI
LGVIVECKSW KDSTAMILSV ISGRLVYPHN GKEILTMKRV CSQSDTLETK PSYGARLELS
KDHDVALSLK ATLQPLEAAY DGGFILAVSN FFSGSRYFKL QHERILSSLN GLESETRLAA
KAEYLLSSRN KVKWDLDIKD LTLSFPGRLV ESESYNLVLV LESLSITSSS TDALSQIPRL
QSDVDHVVNS LQSSVEALDA FQVKDLYDHF DIKICNLEMK LMKIHPFQEL PLVEKSSLLI
KFASCIIPEE SILKQLEVEA TLPMFNVHFS PSIFKGVMSV IEYLDIQDHG TRNPPPSPAP
IFHFTIKTDL AFLRLHVNLE NKGENSTVLV LSIQQLDLWY SRAIFEEWSV RAKTLEITAC
SSKDAADSHI LCSSGNLLKS SSHGHGMDAH TSDETNIIDY RTTPEAAISL NCKVSQSKSF
IFHKYTVYWR SAELHCYPYI FGLLTNFLDK IASYKISSSY TNPSSLATDT IAPTEIPQFD
FERFGFSNFT ESRSCGCIPL DKFPFVTINN SGSLHSLESS LCYSTSDWRK LFILKNRKDG
AQIGLNCECN SCTFQLKRDC PLNGLASSRD LGQTNHFTVD MHVFNTNVHF HDSSSVFGTI
ILPVSRYFLN ISDDLLDLVA SAEDLMLVSS LFTNYSGGFL WKQSSTDVSQ VLNLRVRKRG
LEPSGSQLEV SIGIQHTYCI LPPEYLAIII GYFSLSDWTS KSGLQSLPQA TELTKAHSEF
AISYKIEILD SSIVLPVEGD DRRQLKVDIQ QLYISFIPEC ALSNVVQHIP QECVIPLNQV
LGRADCLNIF GRDLSVSLLL SESDISTFKK NAVCRSITLA ASIIADTWIR FPCDHNPLTE
LACVMSRVDV CEIVVDDSDA LDGFKAFLDV VDQLSLVDEE SKLFVSDVPQ FLHTKMRLKQ
ELSVAPLEPS TSFIKFRIFV NLLTSKLHRL RKAPGTLLSE PVLQADMKFV CSGELKNNFP
MSLDVQFFKI GLYSLLSSVM LARCINADGD PSALRVRFTE QAENEYDLCF SLPSLDIWLH
FFDWIEVIEL LKSYSQKLED SSEDRFFSKG SKLDMDESIG VVRTICDNTD RVLNVLQTEV
SENSSEVMSF AARSENIGVK IHIPLCTSHT EFPGFMATDV HEISEEEHTN CFKGNYCKYV
SVTACSRSGE LSILGRDVKL SYKIEKLNGI LAISGVDTVR SCSLFGAAQL LVETSIQMDQ
NKIMSIDVGI LSDKVEMHAS HQVLSFWHGI TFDAPETPSS QNSEGNMSIK VQIRDVSLLI
SDGKWGCSGM LLEVLMRNFL LQANLAEKNM ESLVSCDLEV NYNNMHKVLW EPFIEPWNFD
IKLSRKFDAN SLLNNAGLTE VIVASSNQLN LNLTESLFEC IFRIIEMLNI LELMETDAIP
DNKGLSVYCT NSTRTERYSP YVLQNLTSLP LGYQVFQGHD SDVLNISAPV AQNFVQPGCS
VPIYIDNSDT LLIPDRRRSQ FGCSSSESGD AIHHYMKVQL DGTSFASPPH SMDRIGLSYF
EVDFSKTSNS SDNVEKASKS GYGSSFVVPV VYEVSLQQQS KLIRVYSTVI ILNSTSMPLE
LRFDIPFGIS PKILDPIFPG QEFPLPLHLA KSGRLRWRPL GDSYLWSEAH SISKVLSQDS
GIGFRRSFAC YPCHPSHEPF RCCISVQSTS LPASFHINDL SAGNFGQQLH NLDQSREQFI
HQVTLSTPFV VSNCLPDPIS LSIESGGITQ TASLPEGETP FHHIDPSHDL VLEFKLNGCR
TSSLKFSRSE TFSTEAKFSG GKFSQIETIS FDSHVGGGSV YVSCEKTMDA TCGAREVLIF
VPFLLYNCTG TPLIVSDCTN ETKGIYSVIP SCYNLIEQHF VQSRKVGLGI LTSEKDLLDK
AVMEDIPCSP SSSECSNTAS STERFIDKHA TQSTRQVPFA AYPKDSAIVR KRSLSSKSLR
EVCFQGNDES GKVKACIYSP CPISRVSDTM IRVKRDLPGW VNSSSPYPLW SAPFPLVPPS
GSTNVVVPQP SPGESSLLSV TCSILGGALA GRTQAITFQP RYIICNSCSH NLCYKQKGTN
LVSHLAVGQH SQLQWTDTTR ELLVSIRLNE PGWQWSGSFL PDHLGDTQLK IWNYVNKAFN
MVRVEVQNAN MSSGDEKIVG SVHGHVGTNF ILLSDDDMGY MPYRIDNFSN ERLRVYQQKC
ETFDTIVHPY TSCPYAWDEP CYPHRLTIEV PGDRVLGSYA FEITKQPIAV HLRSTSEKPE
RTLLLSICAE GATKVFSVVD SGYHAIKDIK ETFDSRFHEK GKKKLQTDNI IRYTETFLLV
LPSIGISLVN SHPQELVYAC ASNVVLELSQ SVDQQKLSFQ ISSLQIDNPL QNSSYPVILS
FNHDHEVIPP DWGMKNNKAI LLSEIVQQVR GNSCDAVVYV DLAKWRKKDV SLVSFEYINI
RIGEFGLELE LQTLLSLLEF VKAVLPNSQA RLLPLSDPTL RPLIYDTGSK DISSEDTPHA
RNIPVFNKNQ RSIVALPIVV PIGAPWQHIH LLARRRRKIY VETFDLAPIQ FTLSFCSAPW
MLRNGILTSG ESLIHRGLMA LADVEGARIH LKQLTIAHQI TSWESFQEIL VGHYTRQILH
EIYKVFGSAG VIGNPMGFAR NVAFGIKDFL SAPSRSISKS PAGIIQGMAH GTTSLFSSTI
YALSDAATQF SKAAHKGIVA FTFNDHDVAR MEKQQLGEGS RSKGVIGEVF EGLTGLLQSP
IRGAEKHGLP GVISGVAMGI TGLVARPTAS ILEVTGKTAQ SIRNRSRIHN IRSQRHRLRL
PRPLSREQPL RPYSWEEAVG TAVLMEVGDS LKFKGEKLVK CKALKQEGAF VVITGRLVLV
LSSLSLVDFR KQGFLGVPID LVWNIEREIG LESVIHTDCS GGVVRIIGSN SDGVWNWRQD
QQKKSSPTKK RWNNPSAQPL LQTNLEFPSE EEAEDLLSVL LSTIETGKSR SWHSRFVLSR
SNIT
//
