UniProt: F4L0V2

Database: UniProt
Entry: F4L0V2_HALH1

LinkDB:  F4L0V2_HALH1 
Original site:  F4L0V2_HALH1

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (2)   
Literature (1)   
   PubMed (1)   
All databases (23)   

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ID   F4L0V2_HALH1            Unreviewed;      1041 AA.
AC   F4L0V2;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=Halhy_2688 {ECO:0000313|EMBL:AEE50556.1};
OS   Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O).
OC   Bacteria; Bacteroidota; Saprospiria; Saprospirales; Haliscomenobacteraceae;
OC   Haliscomenobacter.
OX   NCBI_TaxID=760192 {ECO:0000313|EMBL:AEE50556.1, ECO:0000313|Proteomes:UP000008461};
RN   [1] {ECO:0000313|EMBL:AEE50556.1, ECO:0000313|Proteomes:UP000008461}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27775 / DSM 1100 / LMG 10767 / O
RC   {ECO:0000313|Proteomes:UP000008461};
RX   PubMed=21886862; DOI=10.4056/sigs.1964579;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Daligault H., Lapidus A., Zeytun A., Nolan M., Lucas S., Del Rio T.G.,
RA   Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA   Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N., Pati A.,
RA   Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Rohde M.,
RA   Verbarg S., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Woyke T.;
RT   "Complete genome sequence of Haliscomenobacter hydrossis type strain (O).";
RL   Stand. Genomic Sci. 4:352-360(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DSM 1100;
RG   US DOE Joint Genome Institute (JGI-PGF);
RA   Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Pagani I.,
RA   Daligault H., Detter J.C., Han C., Land M., Hauser L., Markowitz V.,
RA   Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Verbarg S., Frueling A.,
RA   Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "Complete sequence of chromosome of Haliscomenobacter hydrossis DSM 1100.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|ARBA:ARBA00009922}.
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DR   EMBL; CP002691; AEE50556.1; -; Genomic_DNA.
DR   RefSeq; WP_013765104.1; NC_015510.1.
DR   AlphaFoldDB; F4L0V2; -.
DR   STRING; 760192.Halhy_2688; -.
DR   GeneID; 78192522; -.
DR   KEGG; hhy:Halhy_2688; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG2887; Bacteria.
DR   HOGENOM; CLU_006382_0_0_10; -.
DR   OrthoDB; 9810135at2; -.
DR   Proteomes; UP000008461; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd17932; DEXQc_UvrD; 1.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.90.320.10; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011604; PDDEXK-like_dom_sf.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000008461}.
FT   DOMAIN          12..338
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   DOMAIN          339..636
FT                   /note="UvrD-like helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51217"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   1041 AA;  121131 MW;  92EE463E825999F1 CRC64;
     MQYTESFLRE LAKLNPAQRS AVEQIEGPVM VIAGPGTGKT HILAARIGKI LLETDTQAQN
     ILCLTFTDAG VTAMRERLLQ LIGPDGHRVH IYTFHSFCNA VIQDNLELFG RQDLEPLGDL
     EKVDLIRALI DELDVEHPLK RGQSDVYFYE THLQDFFQRC KMEDWTAEYV IQQIDAWLAS
     LPDRPEYRYQ RKQGAQQKGD LKEAKIKEEQ IRMQRLRAAA ALYPRYEAAK QAARRYDYQD
     MILWVLRAFE THDYLLRSYQ EQYLYVLVDE YQDTNGSQNE ILLQLINYWE TPNVFLVGDD
     DQSIFEFQGA RLKNLTDFYA KYQHNLHTVV LTENYRSVQG FLDAAGQLIQ NNQLRIISHL
     QALGLNKNLV AAAVKGKATP LISEYPNRIS EETDIVQQIE ALQQKGIPLQ EIAIIYAQHR
     QVRNLLGLLE KKGIPYQTRR DVNILELPLI QRLRSLLDYL HHETLQPHSG ELRLFQILHA
     HFLGISPLDL ARLSTHLARF PADVRPPWRE LLLDHAALGE LNLEKPAVLT NFAILLEELI
     ADCLNEPLPT LLEKLLNRSG FLQYILEQPN HAWQIQVLHT FFQYVREECQ RRPHYSLAEL
     LHNLHRMEAN RLPLALSRLS DDQVGVHLLT AHAAKGLEFT AVFMLDCVKD YWEPASGRNS
     YRFTLPETLT YSGEEDATEA RRRLFYVALT RAKTFLHLSY ARQDDSEKEL QRALYIDELL
     STQTLALEQK VLPAPLVLST QLLRLQEQQK PSVAPQDRSM IEAILRNFRM SISALNTFLN
     CPLAFYYEYI LKVPGLHNEA TAYGTAVHNA LQRLFDRMLL SPQRLFPSEK ELLYFFEQEL
     NRQRQQLSLP SFERRLELGK RQLGRYYQYY YGRWHKRVRV EYTIRQIEVD GVPLTGTIDK
     IEFYDQLRVG IIDYKTGSHD GTKLRRPTDT NPYGGTYWRQ LLFYKLLYEH FDRSSRRVTF
     GEIAYLDPTP DGQFPEVRLS FTPEDTAFMR QMIREAYAKI RKHEFYEGCG KANCAWCNFV
     KREGGVDRIE RVVVGELDDR G
//

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