ID F4L5S1_HALH1 Unreviewed; 450 AA.
AC F4L5S1;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Hydroxymethylglutaryl-CoA reductase, degradative {ECO:0000313|EMBL:AEE52031.1};
DE EC=1.1.1.88 {ECO:0000313|EMBL:AEE52031.1};
GN OrderedLocusNames=Halhy_4185 {ECO:0000313|EMBL:AEE52031.1};
OS Haliscomenobacter hydrossis (strain ATCC 27775 / DSM 1100 / LMG 10767 / O).
OC Bacteria; Bacteroidota; Saprospiria; Saprospirales; Haliscomenobacteraceae;
OC Haliscomenobacter.
OX NCBI_TaxID=760192 {ECO:0000313|EMBL:AEE52031.1, ECO:0000313|Proteomes:UP000008461};
RN [1] {ECO:0000313|EMBL:AEE52031.1, ECO:0000313|Proteomes:UP000008461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27775 / DSM 1100 / LMG 10767 / O
RC {ECO:0000313|Proteomes:UP000008461};
RX PubMed=21886862; DOI=10.4056/sigs.1964579;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Daligault H., Lapidus A., Zeytun A., Nolan M., Lucas S., Del Rio T.G.,
RA Tice H., Cheng J.F., Tapia R., Han C., Goodwin L., Pitluck S., Liolios K.,
RA Pagani I., Ivanova N., Huntemann M., Mavromatis K., Mikhailova N., Pati A.,
RA Chen A., Palaniappan K., Land M., Hauser L., Brambilla E.M., Rohde M.,
RA Verbarg S., Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Woyke T.;
RT "Complete genome sequence of Haliscomenobacter hydrossis type strain (O).";
RL Stand. Genomic Sci. 4:352-360(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 1100;
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Pagani I.,
RA Daligault H., Detter J.C., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Verbarg S., Frueling A.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "Complete sequence of chromosome of Haliscomenobacter hydrossis DSM 1100.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HMG-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00007661}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002691; AEE52031.1; -; Genomic_DNA.
DR RefSeq; WP_013766569.1; NC_015510.1.
DR AlphaFoldDB; F4L5S1; -.
DR STRING; 760192.Halhy_4185; -.
DR GeneID; 78193921; -.
DR KEGG; hhy:Halhy_4185; -.
DR eggNOG; COG1257; Bacteria.
DR HOGENOM; CLU_033422_0_0_10; -.
DR OrthoDB; 9764892at2; -.
DR Proteomes; UP000008461; Chromosome.
DR GO; GO:0140643; F:hydroxymethylglutaryl-CoA reductase (NADH) activity; IEA:UniProtKB-EC.
DR GO; GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.
DR GO; GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
DR CDD; cd00644; HMG-CoA_reductase_classII; 1.
DR InterPro; IPR002202; HMG_CoA_Rdtase.
DR InterPro; IPR004553; HMG_CoA_Rdtase_bac-typ.
DR InterPro; IPR023074; HMG_CoA_Rdtase_cat_sf.
DR InterPro; IPR023076; HMG_CoA_Rdtase_CS.
DR InterPro; IPR009023; HMG_CoA_Rdtase_NAD(P)-bd_sf.
DR InterPro; IPR009029; HMG_CoA_Rdtase_sub-bd_dom_sf.
DR PANTHER; PTHR10572; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR PANTHER; PTHR10572:SF24; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE; 1.
DR Pfam; PF00368; HMG-CoA_red; 1.
DR PRINTS; PR00071; HMGCOARDTASE.
DR SUPFAM; SSF55035; NAD-binding domain of HMG-CoA reductase; 1.
DR SUPFAM; SSF56542; Substrate-binding domain of HMG-CoA reductase; 1.
DR PROSITE; PS00066; HMG_COA_REDUCTASE_1; 1.
DR PROSITE; PS50065; HMG_COA_REDUCTASE_4; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AEE52031.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008461}.
SQ SEQUENCE 450 AA; 49888 MW; DA7461B8B0C12154 CRC64;
MQEKSISGLH KLSKEEKMHW LAVHYTTAPE ETLEVLRSFW HEDEELQRVM DGFSENTLSN
YFFPYGIAPN FLIDGRLYAV PMVIEESSVV AAAASASKYW LSKGGFKTTV LGTTKLGQLH
FSWSGDAAKL QKLMPELRHQ LLEDVQPITT NMEKRGGGVL SIELLDMGEL EPHYFQLRVS
FETCDSMGAN FINSVLEEFG RSLQLFMSSH PAMHAHEREV EIIMAILSNY TPDCIVRAEV
SCPVEALDDA CINLDGSGFA EKFAKAVRIA EIDPYRAATH NKGIYNGVDA VVIATGNDFR
ATEACGHTYA TRDGQYRSLS HCRVEEGVFT FWLDLPIALG TVGGLTKLHP LAHLSLDILG
QPSAPELMSI IAATGLAQNF AAVRSLVTTG IQKGHMKMHL MNILNHLGGD TSDCLAAELY
FQDRVVSFSA VREFLDRREE EKQKAPAKAI
//
