ID   F4LN15_TREBD            Unreviewed;      1473 AA.
AC   F4LN15;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   SubName: Full=Tetratricopeptide TPR_1 repeat-containing protein {ECO:0000313|EMBL:AEE15801.1};
GN   OrderedLocusNames=Trebr_0354 {ECO:0000313|EMBL:AEE15801.1};
OS   Treponema brennaborense (strain DSM 12168 / CIP 105900 / DD5/3).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=906968 {ECO:0000313|EMBL:AEE15801.1, ECO:0000313|Proteomes:UP000006546};
RN   [1] {ECO:0000313|Proteomes:UP000006546}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 12168 / CIP 105900 / DD5/3
RC   {ECO:0000313|Proteomes:UP000006546};
RA   Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA   Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Pagani I.,
RA   Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA   Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S.,
RA   Wellnitz S., Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Treponema brennaborense DSM 12168.";
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP002696; AEE15801.1; -; Genomic_DNA.
DR   RefSeq; WP_013757520.1; NC_015500.1.
DR   STRING; 906968.Trebr_0354; -.
DR   KEGG; tbe:Trebr_0354; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   HOGENOM; CLU_004435_4_0_12; -.
DR   Proteomes; UP000006546; Chromosome.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00028; TPR; 2.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006546}.
FT   DOMAIN          55..198
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          422..458
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1473 AA;  165403 MW;  582F2FE50D1C2668 CRC64;
     MCKNDCVRCK TLTGFIPSRR EVASIITYLP HRIVNQLDEC PCCVFERNKE QLRGTVVYID
     LVGFTPIVLN YIKDARGPIE NLSEIFFEYF NRLIEPIQKL GGSVYQIAGD SLLIGFELLA
     GETEYTNWNR AWTAVQICCA NSAAYNAECK ERNGFELVPK TGVGFGDFYQ LIVGKRGNLH
     TLDAAADSDT VSLGSDAEPL DSAHPYAGEQ YFTAIICGRA VDDAVNSEKS CKPARIVLAA
     SAMSAMRKYV AAPPACTPIG DSFYELSPAG DWHGDYDPVQ CELELNRKID ELSNERFFGR
     ALSFTAPQLH EQIIKNFKLF SGEYRDVSCV MVQVSGDFID TVGDDRQFSA GFGNFSNLYD
     IIQEDALRFG GFLLKPDISD KGNVFPVLFG APNAIENAEK KAVLFSDALY KKSIQLPFVD
     ALSIGIASGK VYCGEIGSKM RKDFSVVGVT VNLASRFMTA SGKNCIFTDE ATKNAIPDLC
     EFSEKMLIKA KGFTEPQPVY RILSVRHAGG SRKKSVLIGR REELEFLKSR QKLSEAGNRL
     ITGIIGDAGM GKSLLVETLL EDIGRGRSVP EIICGSCYQY EQTTTFYPWR EIVRTMFDIP
     EACRPEELEE LLREKTEQLF SDEQKKWTVP FFIMMGCLVE EPDEIKDIDP SIKQMKIFSL
     VNHILSDRAQ DHPVVIVIED IHWIDHLSLK LVEYLGAAVA DSPVHFILPS RQEDCFAHVK
     SCHNVSVLHL KKLEHDAAFE LAQRLLNSES EEAVLIEKII GAADCNPFFI ENIVLNLVSE
     GSLQELDTGK RRLVKSIDQI VIPSSIQGII LSRLDSLKFD EQIIIKTASV MGRTFIPEIL
     QAVIPPSIPE NVFKTALYHC EANNFILCEQ AETVNYIFKH VMIRDALYNT LLERTRHEIN
     KLLLLYLEHA FKDNLIPICE RLAYHSIESG DTERIITYSL MAASKAEKQY AIQESVHHYE
     NALRSIENSG DALVLKKLGS VQLRLASVYR QSGEYRKAVA LYNEAKKSAA SKMELAEIWR
     GVGHCYQEQG SFSDAIGALE TSLKLLGIHT PKRPVYIGLS LVREVLVQVC NWLFFKDSAI
     QAKNAQIDRI EKICQNFLVL DKLYYFDRAE KLAWSTIAGH NMAAKLAGRS DIRCISNADY
     GVTLLSIGML KLSRHQFGIA EKASEAMSNA TVSSIYKARY AFFYLFYNQP IRSMQLLEEA
     VAHFRNAGEM WELMTAEGAL AQNYFLISDV RKSEKAYRES GDIATRLNSP MHIGWAYNKI
     PFIKYLCAEL AAREAEQVLK KGIKLSASTN DHMTLCIHYG HLCYIAEKEK NVQKTVEYVR
     QIMRENEKYP VNIPHVKISY VNAAEGILFV LERIADGAVD ASDLPCSVFK LEKLLRRALK
     QAERLGETFD LIKGGALRAQ ARYARYSGNT GKAARLALLA SDFLKTTPFR WEYANALLET
     ARCIPERAEA CRSKARRIFT ECGMHGEAQR MGE
//