ID F4LN57_TREBD Unreviewed; 436 AA.
AC F4LN57;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Homoaconitate hydratase family protein {ECO:0000313|EMBL:AEE16822.1};
GN OrderedLocusNames=Trebr_1398 {ECO:0000313|EMBL:AEE16822.1};
OS Treponema brennaborense (strain DSM 12168 / CIP 105900 / DD5/3).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC Treponema.
OX NCBI_TaxID=906968 {ECO:0000313|EMBL:AEE16822.1, ECO:0000313|Proteomes:UP000006546};
RN [1] {ECO:0000313|Proteomes:UP000006546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12168 / CIP 105900 / DD5/3
RC {ECO:0000313|Proteomes:UP000006546};
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Mikhailova N., Pagani I.,
RA Teshima H., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Gronow S.,
RA Wellnitz S., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Treponema brennaborense DSM 12168.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP002696; AEE16822.1; -; Genomic_DNA.
DR RefSeq; WP_013758527.1; NC_015500.1.
DR AlphaFoldDB; F4LN57; -.
DR STRING; 906968.Trebr_1398; -.
DR KEGG; tbe:Trebr_1398; -.
DR eggNOG; COG0065; Bacteria.
DR HOGENOM; CLU_006714_3_4_12; -.
DR OrthoDB; 9802769at2; -.
DR Proteomes; UP000006546; Chromosome.
DR GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:InterPro.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR CDD; cd01583; IPMI; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR006251; Homoacnase/IPMdehydase_lsu.
DR InterPro; IPR033941; IPMI_cat.
DR NCBIfam; TIGR01343; hacA_fam; 1.
DR PANTHER; PTHR43822:SF2; 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43822; HOMOACONITASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00330; Aconitase; 2.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR PROSITE; PS00450; ACONITASE_1; 1.
DR PROSITE; PS01244; ACONITASE_2; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006546}.
FT DOMAIN 7..295
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 294..423
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
SQ SEQUENCE 436 AA; 46762 MW; EF96DDEB9C1D9E62 CRC64;
MGKTIAQKIF ETHVAEKPFQ DTWVLKLDRV FCHEITTPVA ITDLAENGKD RVFDPSKIKA
VIDHVTPAKD SKTALQGKIL REWAFRNHIK DFFDIGANGV CHAIFPEKGF VRPGFTVIMG
DSHTCTHGAF GAFAAGVGTT DLEVGILKGV CSFKEPKTIK FVLNGTLPAG VYAKDVILYI
IGKIGVNGAT NCVMEFAGPI IDAMSMEARM TVCNMAVEAG ATSGICMPDM TTVEYLWPFI
KDDFASKEAA LAEYATWCSD ADAAYERVYT YDLSDLEPLA TFGFKPDQVK PIRELAGTKV
DQVYIGSCTN GRIEDLREAA KVLAEALSQG KRIAPGVRGI LSPATPSIYK KALEEGILAT
FMDFGFCVTN PTCGACLGMS NGVLAENEVC ASTTNRNFNG RMGKGGVVHL MSPASAAATA
VAGTITNSSL FKGNVK
//
