ID F4NRB7_BATDJ Unreviewed; 512 AA.
AC F4NRB7;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=BATDEDRAFT_85657 {ECO:0000313|EMBL:EGF82923.1};
OS Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211) (Frog chytrid
OS fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=684364 {ECO:0000313|EMBL:EGF82923.1, ECO:0000313|Proteomes:UP000007241};
RN [1] {ECO:0000313|EMBL:EGF82923.1, ECO:0000313|Proteomes:UP000007241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAM81 / FGSC 10211 {ECO:0000313|Proteomes:UP000007241};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Kuo A., Salamov A., Schmutz J., Lucas S., Pitluck S., Rosenblum E.,
RA Stajich J., Eisen M., Grigoriev I.V.;
RT "The draft genome of Batrachochytrium dendrobatidis.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; GL882879; EGF82923.1; -; Genomic_DNA.
DR RefSeq; XP_006675910.1; XM_006675847.1.
DR AlphaFoldDB; F4NRB7; -.
DR STRING; 684364.F4NRB7; -.
DR GeneID; 18242149; -.
DR HOGENOM; CLU_009834_22_0_1; -.
DR InParanoid; F4NRB7; -.
DR OMA; AYRNNEH; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000007241; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IBA:GO_Central.
DR GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000007241}.
FT DOMAIN 55..392
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 512 AA; 56941 MW; 720D58684FC477A0 CRC64;
MFTGRSTLTA AYRLKQTMTH LASSSHMRVC TATLATSSKN SASVGVNFKK MQSIRKFELD
RPAAMNALNL DMVYAITSQL KTWKDSDLCK VIVLANVEGS RAFCAGGDVK TLVLKASSGK
PEDIAQSCKF MEEEYKLNHM IATLKLPFVS IMDGITMGGG VGLSVHGSFR IATEKTLFAM
PETAIGLFPD VGGSFFLPRL DGELGTFLGL TGHRLKGEEV FIAGIASHFI PSSRLSSLYS
RLQELDTNNI DVVNAAIDEF SGDFTTDMFR NWSLGGEVGR TIDRCFKYNT IEEIFAALEK
DPNTEWCQKQ LQVMRKCSPT SLKATLMQLR KGAKKSIADC LKMEYRMVRA FMEGPDFHQG
VTAALINKPA TRPNWKPDID HMNEISASMV EKKYFAADQG KQLELFTNST YYDYPHRSLS
GLPTDRDIRR VVYGDISNVN KSGSLKTKSD ILQWFMQNWG KYDSLAMSEH TPPLKLDLGG
GLGRGKVGLK AKVESVLETH TEQQANHLEW KY
//
