ID F4NVP0_BATDJ Unreviewed; 823 AA.
AC F4NVP0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=BATDEDRAFT_34108 {ECO:0000313|EMBL:EGF83306.1};
OS Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211) (Frog chytrid
OS fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=684364 {ECO:0000313|EMBL:EGF83306.1, ECO:0000313|Proteomes:UP000007241};
RN [1] {ECO:0000313|EMBL:EGF83306.1, ECO:0000313|Proteomes:UP000007241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAM81 / FGSC 10211 {ECO:0000313|Proteomes:UP000007241};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Kuo A., Salamov A., Schmutz J., Lucas S., Pitluck S., Rosenblum E.,
RA Stajich J., Eisen M., Grigoriev I.V.;
RT "The draft genome of Batrachochytrium dendrobatidis.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; GL882879; EGF83306.1; -; Genomic_DNA.
DR RefSeq; XP_006675752.1; XM_006675689.1.
DR AlphaFoldDB; F4NVP0; -.
DR STRING; 684364.F4NVP0; -.
DR GeneID; 18240324; -.
DR HOGENOM; CLU_008213_0_0_1; -.
DR InParanoid; F4NVP0; -.
DR OMA; GKQKDPI; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000007241; Unassembled WGS sequence.
DR GO; GO:0000112; C:nucleotide-excision repair factor 3 complex; IBA:GO_Central.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IBA:GO_Central.
DR GO; GO:0097550; C:transcription preinitiation complex; IBA:GO_Central.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IBA:GO_Central.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007241}.
FT DOMAIN 357..519
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 573..731
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 92909 MW; 1300B35E79647497 CRC64;
MATLKRRAKP SQTNSTKQVW TQDDSDSSSS SESKSGWHFS ADVLQGHSTS KNYAALGLKP
DHLLRPLWVC NTGRIILEAF SVLTFQAQDF LTAIAEPVSR PEHIHEYRLT EYSLYAAISV
GLRPKSIIDV LELLSKSHLP EEVKEFIHKH SCSYGKVKVI LRNGRFWLET TDDTVLAKLL
NDPIISNSLV MESKDTSIHI DAALHEDEAA SDNRSIDTFL EEESMPASTT LEPGLDLFDL
FNEDASKPTH IPASGVSQIY NTSAVVPLKT NVAGSIAERF EQLLGESSAG EATLQMTKSF
EIHMQATESV KRRCVDLLLP VLEEYDFCAD SRNPNLEMTL KPFAKLRPYQ ANGLSKVFGN
GRVRSGVVVL PCGSGKTLVG VAAACTVKKN CLVLCTSSVS AEQWRREFCH WSTIKEGHVA
KFTSGSKEKF VGPAGVMIST YTMITYSGKR AYDAQKLMEF IQSREWGLLI LDEVHVVPAE
MFRKVFTIIG THSKLGLTAT LVREDNKIDN LNYLIGPKLY EANWMELARG GHIARVQCAQ
VWCDMTPEFF REFLREKSRK RQLLYTMNPR KVQACQYLVN FHEAMGDKII VFSDNVFALK
HYATKLHRPF IYGGTSQSER FRVLQQFRFN PALNTIFLSK VGDTSIDLPE ASCLIQISSH
YGSRRQEAQR LGRILRAKRG TDTGYNAYFY TLVSKDTEEM YYATKRQQFL IDQGYSFRII
THIEGMDDSA GLAYSSLKDQ LELLNTVLIS TEADYERDVH QDELDDALQT YESEEEAEIE
GVQWMMRSSG TMKSLSGADS MAYLEFNRGT PSILRGKRRR FRE
//
