ID F4P227_BATDJ Unreviewed; 854 AA.
AC F4P227;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BATDEDRAFT_88107 {ECO:0000313|EMBL:EGF81041.1};
OS Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211) (Frog chytrid
OS fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=684364 {ECO:0000313|EMBL:EGF81041.1, ECO:0000313|Proteomes:UP000007241};
RN [1] {ECO:0000313|EMBL:EGF81041.1, ECO:0000313|Proteomes:UP000007241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAM81 / FGSC 10211 {ECO:0000313|Proteomes:UP000007241};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Kuo A., Salamov A., Schmutz J., Lucas S., Pitluck S., Rosenblum E.,
RA Stajich J., Eisen M., Grigoriev I.V.;
RT "The draft genome of Batrachochytrium dendrobatidis.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GL882883; EGF81041.1; -; Genomic_DNA.
DR RefSeq; XP_006678793.1; XM_006678730.1.
DR AlphaFoldDB; F4P227; -.
DR STRING; 684364.F4P227; -.
DR GeneID; 18243029; -.
DR HOGENOM; CLU_334329_0_0_1; -.
DR InParanoid; F4P227; -.
DR OMA; HINRFAY; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000007241; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007241}.
FT REPEAT 36..58
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 70..102
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 412..543
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 612..844
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT COILED 327..375
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 854 AA; 97282 MW; 3B96FE418A976115 CRC64;
MEIITAVSKL DVVLLRKLID GPESAQHDIN FAGPDDGRTA LHIAASNGSS ACLEMLLQQP
TINIDAVDLQ GNTALHLAAA CREMDAVRRI LSYGPDLLIK NKLGNCACEY TDDPQIESLI
QERITASRNI LQASQLMSAW KKTQLGQLDS ELPSDPVKLK ELCIELLIGQ AIFEDRCQDA
LHQLIEEKHI SMYKNRLMEQ SVGIPDRETG EKYMMQLQFW QDEIERQAST ISYLKLQIQV
LETTAAQQED YYKQNLANIT KQQKDQVQTI FKRAEETERA FLNYQKKHSE DAIKASQLHI
LNENADASVA SKETEDSEGN TKIYRQYIEV KAQLDDAEAQ RIMLEERFKS SENLRMLAEL
EAQDLRAEIE KLRKGITEKV MFQIEEGQQK QNKQDEKDES LGEIIFLKNE AGQKSVKAGT
IDKLIERLVD PATYDNQYLQ ALLLTHTVYI DSKELLERIT KICRDSISSA SKSLEPGSTS
SNSSSVILKA ANMIKYWMEQ YWSDFQSNPK LVQLLTTFMD ALENPKLAQM LKTCMNRKLT
GVEAPLIEMP SQCPKPILPK ALLKRVSTDI ASNRESKMME TVSRPISAPW SAFNKKSEIF
MDDLKLKMVD LDPIEVARQL TLIEFELFNA IKAREFLDLA WMKDDKETRA PNIIRMVRWS
NHVVHWLITE IVTIKDNIKL RAAMMEKIIA LAQQLEKLNN FNGVKEVLAA LQSSSVYRLK
KTKELIGGKF IKSFEELKRL TSSELNYKLL RTKVHAVEPP LVPFPGVYQG DLVFLETCGK
TKLEGNLINF QKFQKIASYV LELQTYQQVP YQLGPVPEIQ DFLRNYPVLD DDQTYGLSLA
CEPRFATRGG FANT
//
