ID F4P414_BATDJ Unreviewed; 4521 AA.
AC F4P414;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=BATDEDRAFT_35252 {ECO:0000313|EMBL:EGF79933.1};
OS Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211) (Frog chytrid
OS fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Rhizophydiales;
OC Rhizophydiales incertae sedis; Batrachochytrium.
OX NCBI_TaxID=684364 {ECO:0000313|EMBL:EGF79933.1, ECO:0000313|Proteomes:UP000007241};
RN [1] {ECO:0000313|EMBL:EGF79933.1, ECO:0000313|Proteomes:UP000007241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JAM81 / FGSC 10211 {ECO:0000313|Proteomes:UP000007241};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Kuo A., Salamov A., Schmutz J., Lucas S., Pitluck S., Rosenblum E.,
RA Stajich J., Eisen M., Grigoriev I.V.;
RT "The draft genome of Batrachochytrium dendrobatidis.";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL882885; EGF79933.1; -; Genomic_DNA.
DR RefSeq; XP_006679554.1; XM_006679491.1.
DR STRING; 684364.F4P414; -.
DR GeneID; 18240706; -.
DR HOGENOM; CLU_000038_9_1_1; -.
DR InParanoid; F4P414; -.
DR OMA; FQKRDRY; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000007241; Unassembled WGS sequence.
DR GO; GO:0097729; C:9+2 motile cilium; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036157; C:outer dynein arm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0060294; P:cilium movement involved in cell motility; IBA:GO_Central.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007241}.
FT DOMAIN 1873..2010
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2153..2280
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2481..2629
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3333..3367
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3625..3659
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4521 AA; 515557 MW; B1331ABFC26EB77B CRC64;
MAATTTGSMA NLHRSNMNLA HDSENKKKAA AAQNAIEKKR ASLDVRHRYL LEKFATLVEE
KPATLENALL IGNKLDIVND FLAEGGSRKV LLFWQKDDLS PSKTAGAPQT KPYTLIVTNG
NKEVLTGVGA FFIRTSTKAI SAQNVYLDVS FGPLNPNLLP SLTTMVKHVV MPALRAQESW
GVLAKQKDES VKGFIEALEK FTVDLDVAMV NLHDSVQLHP CNIDLDAYKK PSDYANAAHS
PDITNALEGL VSEWCKQIEQ VLAESEQMRK EADDIGPNAE LAHWKARMVK FNSITDQLKS
FLCRKVIGIL NAVKSRTLLK TWKDLDDRVT DAANESKDNV KYLYTLERFC DPLYRSDPIG
MIPAIPGLIN AIKMIYSISR YYNTSERMTS LFVKITNQMI TSCKEFVYKD GGSKIWDLDR
QVLVRKLMDC HKLNEAYQRC FHEIKKKLQE TPHEKQFDFS EMYIFGKFDA FCKRIQKVID
MFNIIEKFSL LETLGVEGLD SIVRKFSNIL IQMQRKPYDI LDHRKMEYDS DYNNFKKQVS
DLESTLQQFI DTSFEHIINT EQSLELLSKF SQIKDMQLDL ENKYHTVFVH YTRKELEGVR
KLYQKYKDAP PISRNTPPVS GSIAWARQLY RRIETPMKRF KSSTSVLDSS EAKKHIRNYN
KLARALIEFE VLWHRSWYSI VDQAKTGLQA TLLVSNDEGH VYVNFDPQIL QLIKETKCMV
RLGLEVPESV KNVCTKEIYY KNLYNGLVHI LQTKKRVLER VSNGLRRAMG PHIDELDRTL
QPGLTALTWT SLNLDDYLQA NHRQLAKLEE LVDKLLDISE CRIEMGVRKT AEIMLVEIPS
ETEQWSVDTF LDKTEKRCTA MLQTINNRSN LIESATRDII AELSKGIEKS INSDLRLAYE
SVYYSSNYLN FEALVQNTKG SLDMLRGRLG TYTTSQYNKA PNQKPFFRAE IVLLIPNVVL
QPKLEDIQGA LNKAATMVVD VSKKLTLNWS VFLDQPDDHT TGHYPEDTFQ VANNKDVLKV
IMLLSSTVNS MKKDVETHRE QFGKYDFLWK EDKVDTIQKF LGNNPTIADF ENEINRYEFI
EHEIMEISGS TQIGLLLISA EPLKLALLSE TKEWKQQYGL NLNRKVKTDM EQLIEYMESK
TIKLSRKIAD IDDLRIAVQT LSEIREAEVD IDMKVAPIEE AYLLLTKHNV TVTREETEMV
DSLRYSWKKL KILVIDTQAH LGKIQPVFKA DLIGSVQKFS QDVKDFTVEY TENGPMAGNI
PPKTASERLN VFQRGFDELN RKWETYSAGE ELFCLQVTPF PTLVRIKKEL KLLQNLYSLY
NDVLEKRQTY SETLWSDIDL EKINTEMTDF QNKIKKLPKA IKDWDAFTEL KNIVENLSSM
VPLLEMMCNK SMQQRHWDII MSITKTQINL DPDMFYLKNL LDASLVENRE DIEDTCTAAI
KEADIEIKLK ATVADWEDKN FTLAAFKTRG NLVLKPSATS EIISQMEDSL MTLASLMSNR
YNAPFKPTIQ TWVHNLSTAS EVIENWLAVQ NLWIYLEAVF VGGDIAKQMP KEAKRFSNID
KSWCKIMGLA NEHPNVIQCC VLDETIANLL PHLTEQLELC QKSLSGYLES KRAIFPRFYF
VSDPALLEIL GQASDSHTIQ AHLKSVFDNI DKVQFHDKEY DKIIGLESSE GERVSLSRPM
LAAGSVEMWL GTLLKSMQSS VNDIIREAAS RVNDVPTQKF MDEYPAQIGL LCLQIQWTQM
CEEGLTLSKT DKKKMAATNQ RITEILNILI ENTTRDLSKM DRVKYETLIT IQVHHRDVFE
KLYKTHVKSP DDFEWLKQAR FYWQETKDCC VVSITNFDFK YQCEYLGNTD RLVITPLTDR
CYITLAQALG MSLGGSPAGP AGTGKTESVK DLGKNLGKWV VVFNCSDQMD YRGLGRIYKG
LAQSGCWGCF DEFNRIELPV LSVAAQQIGC VFSARKERKT SFIFTDGDTV ELNPEVGMFI
TMNPGYAGRV ELPENLKVHF RYVAMMVPDR QIIIRVKLAG CGFISNLILA KKFFVLYRLC
EEQLSKQVHY DFGLRNILSV LRTCGSVKRA NPEDSENLII MRVLRDMNLS KLVDEDESLF
LSLVNDLFPG LSAKKGSYPN VETAVDQQLA EVNLISHPPW TLKVIQLYET AKVRHGIMIL
GPTGTGKTKC INALLKAMTA CGDPHKELRM NPKAITDYQM FGKLDVATND WTDGIFSSLW
RKTLKRKGET VWIILDGPVD AVWIENLNSV LDDNKCLTLA NGDRIPMSPA CKLTFEVHSL
RNASPATVSR CGMIYIGVIT LTWDIVLQSW LKVRPLNEVG VLEALFNSSF GSVNQFLILE
LHPKMIIAPV NYVVNTTILL NGLIPKAEAN KSQVSAEHLE RLYVYALFWS FGSLLELDER
KKLQHFMIEK IPDLKYPPID PNSQDTFYEF FVNDNGQWQH WRDRVVDWMY PQDITPEFSS
IIIPMVDNVR TEFMMETVTK QGRAVLLIGE PGTAKTVTVK KYLAKLNPDT HLSKNLSFSS
ATTPMIFQRT IESYLDKRMG STYGPPAGKK MIIFIDDINM PEINEWGDQV TGEIVRQLME
YQGFYSLDRP GDWTAIVDLF FLGAMMHPGG GRNDIPSRLK RQFVVFNCTI PSDNSVDKIF
GTMLEGHFCA ARNFAPDVVS MIARMPPLMR RLWQMTKVKM LPTPAKFHYI FNLRDLSRIV
EGMLNSTPES VPNEKILLNL WEHECSRVLP DRFITQEDAD WFSKATVSLI QKDLGDEYSA
VVANKSYFAD FMREPPENED PEAEVDLEAL KIYEKVASFD ALRERLTEYM KQYNESIRGS
KMDLVLFEDA MKHIARISRI IRMPRGNALL VGVGGSGKQS LTKLAAFIAK SQVFQIAITK
NYNVSNLMED LKLMYKVAGA QGKSMTFIFT DNEVKEEGFL GFINNILTSG EIANLFAKDE
VISISSDLRG SLKKQRPNVI DTIENLWQFF IDRVKANLHV VLCFSPVGDK FRNRSLKFPG
LVSGCTMDWF SRWPNEALRA VADKFVSEMD IACSDQTKKE VVYHMAFVHD LVTDACNNYF
MQFRRRTHVT PKSYLSFLAS YKSYYRNKRE EVGGLSDRMN MGLSKLVEAS KSVAVLQDQL
VVKEKELAVA SKAADAVLAE VTASTMSAEK VKDAVLKVKT KSEGIANTIK ADKVYAESQL
EAAKPALEEA RNALNSIQPA HISTVRKLAK PPHLIMRIMD GVLLLMKRRI DTITQDPDKP
CMKPSWSESL KLMSASDFLT NLLNFAKDEI NEETVEFLEP LMEMPDFNLE GAKKVSADVA
GLASWVGAMA TYYGVNKKVI PLKANLIVQE HKLTIAMEDL NKAQQMLDEK QAELDVFQAK
YNEAISNKQM LQADADSCKR KMNAATALIS GLKGEKDRWT IQSKEFAERI GRLVGDIILA
TAFLSYSGPF NQTFRSQLLQ DWRKELSRRK IPHTEDLDII GLLVDNTTVG EWNIQGLPTD
ELSIQNGIIV TKGTRFPLLI DPQNQAKVWI KNREEQNKLQ VTTLTHKYFR QHIDDCVSQG
RPLLIEDVEE ALDPTLDNIL ERNLIKAGRG FKVVFGDKEI DWCDGFYVFI TTKLPNPNYN
PEIYAKCSII DFTVTSKGLE EQLLGRVIMR EKQELETERA KLLEEVNFNK RKMKQLEDNL
LERLTSTKGS LVDDESLIEV LAVTKTTAEE VNEKLVVAAD TQKKISIARE EYRPVASRGS
IIYFLIAEMS MVNVMYQTSL KQFLQLFDES MEKGTPSPIP SKRIQNIIEY CTFRAFSYIT
RGLYEIHKVI FVLLLALKID VFHNKVTHEE FRCLIKGGAM LDINTVTKKP FNWIPDMTWL
NLVALSKMPG FADVLNQVGK NEKAWRSWYE KDAPENELLP GGYQNSLDAF RRLLLVRSWC
LDRTGMMSKQ YVASSMTVRF AESQILDLDS LLGESNNRTP MICLLSQGSD PSSDIENLSK
KYKIDMKAIS MGQGQEVHAR KLLSTFMTNG GWALLQNCHL GLPFMDELLS LIVETEAIHE
KFRLWITTDV SIKFPITFLQ TSIKFTNEPP QGVKAGLKRT YAWFTQDMLD MSARPQYKPL
LYGLAFLHSI VQERRKFGPL GWNIPYEFNQ SDLAASVQFV QNHVDELAPK ASISWNTARF
MFCEVHYGGR VTDDYDRRLL QTYGKVWFGD HMFLDTFCFY KGYTIPHLKT IDEYRQSIEV
LPLTDTPDAF GLHPNADISC QTKESQRMLD TIMSIQPKDS GGGSGETREE IVKRMANDLL
SKLPESFDKN RTKLTIQKQG GPKPLNIFLG QEIDRMQAVI SAVKSTLSDL RLAIDGTIIM
ASGLQNALDA LYDARVPESW VKISWQSSTL GLWYSEFLGR AAQFHTWLYD GRPLVFWLSG
FFNPQGFLTA IRQEITRTHN GWALDNVKLA PEVMKHMKED ITAPPSEGVY IYGLFIEGAG
WDRKNIRLTE SQPKVIFQSM PVVHVSATNS TDDGDPRMYR CPVYRRPRRT DQNYIFDIEL
KTQQTPDYWI LRGIALLCAT S
//
