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Database: UniProt
Entry: F4Q324_CAVFA
LinkDB: F4Q324_CAVFA
Original site: F4Q324_CAVFA 
ID   F4Q324_CAVFA            Unreviewed;      2843 AA.
AC   F4Q324;
DT   28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT   28-JUN-2011, sequence version 1.
DT   13-FEB-2019, entry version 32.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor-like protein {ECO:0000313|EMBL:EGG17588.1};
GN   Name=iplA {ECO:0000313|EMBL:EGG17588.1};
GN   ORFNames=DFA_08584 {ECO:0000313|EMBL:EGG17588.1};
OS   Cavenderia fasciculata (strain SH3) (Slime mold) (Dictyostelium
OS   fasciculatum).
OC   Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Acytosteliales;
OC   Cavenderiaceae; Cavenderia.
OX   NCBI_TaxID=1054147 {ECO:0000313|Proteomes:UP000007797};
RN   [1] {ECO:0000313|EMBL:EGG17588.1, ECO:0000313|Proteomes:UP000007797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH3 {ECO:0000313|EMBL:EGG17588.1,
RC   ECO:0000313|Proteomes:UP000007797};
RA   Gloeckner G., Schaap P., Noegel A.A., Felder M., Eichinger L.,
RA   Heidel A.J., Platzer M.;
RT   "Living fossils from the dawn of multicellularity.";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000007797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH3 {ECO:0000313|Proteomes:UP000007797};
RX   PubMed=21757610; DOI=10.1101/gr.121137.111;
RA   Heidel A.J., Lawal H.M., Felder M., Schilde C., Helps N.R.,
RA   Tunggal B., Rivero F., John U., Schleicher M., Eichinger L.,
RA   Platzer M., Noegel A.A., Schaap P., Gloeckner G.;
RT   "Phylogeny-wide analysis of social amoeba genomes highlights ancient
RT   origins for complex intercellular communication.";
RL   Genome Res. 21:1882-1891(2011).
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DR   EMBL; GL883021; EGG17588.1; -; Genomic_DNA.
DR   RefSeq; XP_004356072.1; XM_004356019.1.
DR   EnsemblProtists; EGG17588; EGG17588; DFA_08584.
DR   GeneID; 14869627; -.
DR   KEGG; dfa:DFA_08584; -.
DR   Proteomes; UP000007797; Unassembled WGS sequence.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:EnsemblProtists.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:EnsemblProtists.
DR   GO; GO:0005509; F:calcium ion binding; IEA:EnsemblProtists.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IEA:EnsemblProtists.
DR   GO; GO:0048102; P:autophagic cell death; IEA:EnsemblProtists.
DR   GO; GO:0097231; P:cell motility in response to calcium ion; IEA:EnsemblProtists.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IEA:EnsemblProtists.
DR   GO; GO:0034670; P:chemotaxis to arachidonic acid; IEA:EnsemblProtists.
DR   GO; GO:1903669; P:positive regulation of chemorepellent activity; IEA:EnsemblProtists.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50919; MIR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007797};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EGG17588.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007797};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2401   2420       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2440   2473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2518   2543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2564   2588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2644   2671       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      115    164       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      172    220       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2797   2817       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2843 AA;  324628 MW;  8651377F4BD5EFE6 CRC64;
     MDENLSIKTG DLVTFFSEQE EEEGYFSKAH DSAVLHPTKT KECVFKIHPM TQYTARKALK
     KKTKRKTQRE GPSGSVVGGG GVVGADEKDA ELKQLEEYQD IEDAANETTL IQLEGRDLIY
     GQIIQLFHPK SNQFLFAKYY NAGHSIVGFR GDGNQKCYFK IAPRGGVVRQ DGEKVRQDDL
     VMLRHEKTGL FLRETDFFNE KGFFEIGLSD SGTSWKLSLS DVEGKMGLNV VRAGEPFRLF
     HREGGFIKTA TDESSTTFTY KTSTPQSIRS IFEIEIDNGA ATILSRAQQQ QQSSSGVNSP
     LPFQSTTALL SLTQQSQDIQ YGQPFWIKLI GTKYYFSLKQ DSLQDTKDQS PTSNNNNNNN
     NNNNILSSSS SSIKEEGGAQ LPTSPVTANT SSVSGVPVDP YKDLPIVLVP ESEKYSPHST
     FCFISKDQSA TEAAVTYGSF ARIQSLSKQW LHFVSDETFH NNGDLVGTKK HFKNDDFQIK
     QIPRSQMDDY NYVIVRLNKL QSYLGGGNGL LEMRKKVTIQ EVRSILVELI KFCTQSDLDA
     LEREGTPITT HQNLLASPFA INTMMDLLSR FFSTSDRRQE FPLIGYIYRL LKLVVKSNIK
     NAIAVHKHFR HIAGPIHLRS EMIAFGLGSI LLDIYRNNNI LLGSITEDKV SEFIDNMKLT
     KDPRYMELLS EICHCNGHPI VKNQQYLCSL LLEKNPQLMM RTRVTQSVEI EVDGTWMTMA
     EFMNRGREDR QRYFEQSLAL YANVSRGRNY NGIRLIGNFA SYKECFLCLK DDNLPFGLRG
     SYTHLVIHVF MDCYPQKPYA KINYLWNPLT MEAPSGYQHG SGSVNSPNGL GMGGGGGPIS
     VSVASTANQM NLQHQQQQSG GLRTKHSNST NDLGMSPLQN GANPAYGTSP RIPSQTVSLD
     QDEIFTTFLG HDPIHNIDPS NISQFLMSYV LRPENFSWNN MFMSHEAERQ RSQWRFFYKI
     LIAVRYAFKF GFFKRKEKLL LNRLRDILEL QNEGNDHAVQ VDLGRTMGGS RLLEDDSTVL
     VSIKIEILNI LHIMLSLQKK TVFEGFLYEM SKTDSIRNAA SSPTHNFEAA GLAEANIKKM
     MGTFLGQRPS SPTTSASSNN HNTQAQRSAM VTHKNTFTNT LFSLLKHENN VLTSLVLDLL
     TRIYKYQSHY ALLSNPVKKL MILSSNVANS IYDQSVRRME DLTKFCSNPL SHQDTEEVLR
     ILTDFTKLCN LDPNSSSGEF NRIKHNQDMF RMMDIHKRLF GVLKMGCSLE DLKDIVDFTL
     DISNNNNNNN NNNNNNNNNN NNSIPTNSSS NNNNNNNSNN TISTSSSLTN INISSTHNNS
     YYVAKIFRGC YEFLRSYCRN NTDNQKILFN YIEFLIGHLI RYGNIFGTVE TLMEIFKDNI
     QLCTKFSETP YMKLLVEFII QQESIMQIDP VFLKFLQVIM VPGGNSVIEI QIAISNLIKE
     HFFVVSKWLL PLDTVRQVMQ DSKGATMTKF FNVNTSESHR LQVALNDVIA QALQNLEDPQ
     LAGSLSSTMN NTLKLGGGPK LIRSTAKHML LNTEILPREF LVNMELIWLL TSCSNGRNVP
     TEIICRDFIS MYDCLSILVI SNNAAGVESS LLIHDNKENL DSNVPFRFKT TYLAFLHEVY
     FNSDTLKGDL LALQLNENLW TLISQFTNQL QHLYTCHALH RMSRDYFLLM SRMVILPMVS
     TMERFYSQCF YYDKATPKHI HYSSLLMGSL LKLYSVDESL PIPTTASSAS LQQQNKVLFP
     DDASGSSGGI NPILSGLDPS EKIILLNSLV KLLKAMDRSA ISPTAAPSSS ISSVSEVIRG
     FEEIIVRLDH LSSKWSRRRD TVSDHPVTSI ALVSKQSTYL NEVSKEHPII RLIKERGYQQ
     LALMAIERDK AHSLMQSEIM RETPSQPLYQ NPYSTSQRDN LTLSTFSNAS STSSVNGASK
     KNTYLEILVF QLRNTLFENN ELKLHCSQIL LSVLDCHPHN KKEMQEQLTQ MYCHQACIGL
     LGSKSYQVQQ QALSLLLVLL EGQSDPTNPK PNEHVKDAIQ SYFTSSPDIQ FFRNIYEMME
     RAKCNLRDTK RNIRLETFKH NIGGNLSLGA RRQTIGMYHE RSTLETDNDH NPYSQEFLMM
     SNIFRVLQLL CQGSSNLFKN YIRLQPDNYK SYDLLKEMCQ FLKILETIVD FDPESINLGL
     RFFSCMKEIV KHTQANQIAV TNVQMCKAVC NILRKTIPND AKQQQHDLYL NLKIEVIDFL
     LHVVDREHPT VIAKMIEEMD FSVIEENTKI FQQSKSEHNE GSIKLASMSF RLVKILADND
     KSHNRRLAEC LLACGEHCRS RIGRVEMFHN GKLERIYFPI PSYSRRLILD DREQSKIRSD
     ENAFQENLEE YFINNHINWN KTTEKLDSFM DWSENKLIDL EHLFKLKSQP LTYRVATNIE
     IWRWTNFFLA CIINVLLVIY SMDPYSTFKK DFGTTRYNAV IYPLGLLQLL FSLLTCISYF
     IRYGSIILFR GWMKYLGNER SFMLRTNHER MQNIRSRFNI YKFLSLNIVF ISSDAKSVYY
     ILAIVFSVLG LAIHPFFFAF HLFQVTVKTK ALGIVIKALA MNKGTLLLMG VFIIQATYLL
     SIFSYAFFSD RYQSTDDGVV SKMCNTFFQC FITNIYFGIP SNGQLVQFLE YHDFGESNDG
     AGMVIAWTVF NVIFYIITTI ILLNVVLGII VDTFGQLRDQ RSQTEDYKTN YCFICSIERE
     VFQKKGIDFH KHVEDDHNKW YYLYFFAYLK ERVINNQQNQ FSDSELNALY KIEHNNSLSL
     FPIETSMSLL GENQNNDSTK MINAIQDLEQ KITSSLISQM NTTISALLEE IKVLRQQIDN
     DKYFYIHFQT TTNQTNISYD GTA
//
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