ID F4RAR2_MELLP Unreviewed; 445 AA.
AC F4RAR2;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN ORFNames=MELLADRAFT_93528 {ECO:0000313|EMBL:EGG10524.1};
OS Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf
OS rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Melampsoraceae; Melampsora.
OX NCBI_TaxID=747676 {ECO:0000313|Proteomes:UP000001072};
RN [1] {ECO:0000313|Proteomes:UP000001072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=98AG31 / pathotype 3-4-7 {ECO:0000313|Proteomes:UP000001072};
RX PubMed=21536894; DOI=10.1073/pnas.1019315108;
RA Duplessis S., Cuomo C.A., Lin Y.-C., Aerts A., Tisserant E.,
RA Veneault-Fourrey C., Joly D.L., Hacquard S., Amselem J., Cantarel B.L.,
RA Chiu R., Coutinho P.M., Feau N., Field M., Frey P., Gelhaye E.,
RA Goldberg J., Grabherr M.G., Kodira C.D., Kohler A., Kuees U.,
RA Lindquist E.A., Lucas S.M., Mago R., Mauceli E., Morin E., Murat C.,
RA Pangilinan J.L., Park R., Pearson M., Quesneville H., Rouhier N.,
RA Sakthikumar S., Salamov A.A., Schmutz J., Selles B., Shapiro H.,
RA Tanguay P., Tuskan G.A., Henrissat B., Van de Peer Y., Rouze P.,
RA Ellis J.G., Dodds P.N., Schein J.E., Zhong S., Hamelin R.C.,
RA Grigoriev I.V., Szabo L.J., Martin F.;
RT "Obligate biotrophy features unraveled by the genomic analysis of rust
RT fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:9166-9171(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; GL883094; EGG10524.1; -; Genomic_DNA.
DR RefSeq; XP_007405993.1; XM_007405931.1.
DR AlphaFoldDB; F4RAR2; -.
DR STRING; 747676.F4RAR2; -.
DR EnsemblFungi; EGG10524; EGG10524; MELLADRAFT_93528.
DR GeneID; 18936605; -.
DR KEGG; mlr:MELLADRAFT_93528; -.
DR VEuPathDB; FungiDB:MELLADRAFT_93528; -.
DR eggNOG; KOG1325; Eukaryota.
DR HOGENOM; CLU_014602_1_2_1; -.
DR InParanoid; F4RAR2; -.
DR OrthoDB; 1826981at2759; -.
DR Proteomes; UP000001072; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF33; LYSOPHOSPHOLIPASE 1-RELATED; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000001072}.
FT DOMAIN 51..445
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
SQ SEQUENCE 445 AA; 48989 MW; AA439DC980FAF8F3 CRC64;
MLLRWPNQRL RIQLILIVPY AIKTKSVQGL IRRSGAIEDS PTDGYAPTFV TCPANFTVRQ
PSGKTFVGEK ESAYVNEKAS RSNPAWRSYL TRAQLDDFDI ESFLPSNPIP GETLPNIGLA
ISGGGIRALL GCAGVLNAFD DRNEQANLAG TGGVLQLSNY ITGLSGGSWL IGSWATSDFP
TFTSLNESIW NLTEKNSYAS WNSIKRYPKA IKQAELKHKA GFPSSLADVQ AYILSHHLIN
DTHHGTKVLF SSIRNTTGYK NYTAPFPILL STSRHQGKST IDLNTTIYEF SPEEFGVNHP
SLNAYIPIDY LGSHLNSGKP ISNDSCALGF DNAGWVISAS SNVLSQPGVS GSFSWQTIET
EAYNTMTRNI YDEAIVPNPF YKLQEENSTF MYEDQNQKDL YLADGGWGGE VVPFWPLLQP
DRKLDAIIAI DYVADGPSMY HGACE
//
