ID F4RGZ0_MELLP Unreviewed; 723 AA.
AC F4RGZ0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|Pfam:PF13456};
GN ORFNames=MELLADRAFT_85000 {ECO:0000313|EMBL:EGG08325.1};
OS Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf
OS rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Melampsoraceae; Melampsora.
OX NCBI_TaxID=747676 {ECO:0000313|Proteomes:UP000001072};
RN [1] {ECO:0000313|Proteomes:UP000001072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=98AG31 / pathotype 3-4-7 {ECO:0000313|Proteomes:UP000001072};
RX PubMed=21536894; DOI=10.1073/pnas.1019315108;
RA Duplessis S., Cuomo C.A., Lin Y.-C., Aerts A., Tisserant E.,
RA Veneault-Fourrey C., Joly D.L., Hacquard S., Amselem J., Cantarel B.L.,
RA Chiu R., Coutinho P.M., Feau N., Field M., Frey P., Gelhaye E.,
RA Goldberg J., Grabherr M.G., Kodira C.D., Kohler A., Kuees U.,
RA Lindquist E.A., Lucas S.M., Mago R., Mauceli E., Morin E., Murat C.,
RA Pangilinan J.L., Park R., Pearson M., Quesneville H., Rouhier N.,
RA Sakthikumar S., Salamov A.A., Schmutz J., Selles B., Shapiro H.,
RA Tanguay P., Tuskan G.A., Henrissat B., Van de Peer Y., Rouze P.,
RA Ellis J.G., Dodds P.N., Schein J.E., Zhong S., Hamelin R.C.,
RA Grigoriev I.V., Szabo L.J., Martin F.;
RT "Obligate biotrophy features unraveled by the genomic analysis of rust
RT fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:9166-9171(2011).
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DR EMBL; GL883101; EGG08325.1; -; Genomic_DNA.
DR RefSeq; XP_007408523.1; XM_007408461.1.
DR AlphaFoldDB; F4RGZ0; -.
DR STRING; 747676.F4RGZ0; -.
DR EnsemblFungi; EGG08325; EGG08325; MELLADRAFT_85000.
DR GeneID; 18933689; -.
DR KEGG; mlr:MELLADRAFT_85000; -.
DR VEuPathDB; FungiDB:MELLADRAFT_85000; -.
DR eggNOG; ENOG502S0CW; Eukaryota.
DR HOGENOM; CLU_006058_0_3_1; -.
DR InParanoid; F4RGZ0; -.
DR OrthoDB; 1660620at2759; -.
DR Proteomes; UP000001072; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd06222; RNase_H_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR044730; RNase_H-like_dom_plant.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR33050:SF7; DNA_RNA POLYMERASES; 1.
DR PANTHER; PTHR33050; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001072};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 356..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 583..663
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|Pfam:PF13456"
SQ SEQUENCE 723 AA; 81933 MW; 2D21DADF2FD527DE CRC64;
MKWKMQILFQ NVNNSASRII LDTASWGSQL VSVSIAVAVS RTTRVVTMSD QDGPQESCGS
IDTEGTTEEE MVDMGQERNC KGNDKDKVYG DAFIEGPPLA HFSDDFIEPK FLRGYVWDGV
NTPGYSPAIE SSVYAAPFRD APPLSEDIDA AFVLEQYPHL FKIITPIKVD KLELLLRDHP
NQAFVNSALK GLREGFWPNS SIPSSEVVDG PNHISCEANQ SLLEEQCQDE IDKGRYSEEF
TTLLLGMKVI PLLMVTKKDS NKMRVCSNMS AGHPSPNDLI NKSSIPVAYD SLKSFIPYLI
KMKEEEGEVI LFKSDIEGAF RIIPLHFQYQ LRQIYKIRGN KKRVDHNLNF GSSASPFIWC
GVFSLVLWIA EFIFDIKFMN NMMDNVWCVC STKHFVNFKG HLIPLPQAKL LNLFDILGFP
WVWKKQLHGP VLEIIGHIVD SERMIIQLHP DKKRLLIEKL QKFVAHHHHL LNDWQKILGH
ASWACTSMPW GRYALQSLYE KSNTKSHRFL QIPLNKENQD DVRWLIKFFD QSPRILVLTS
LRWGLKEADA EFFTNACMTG VGIWDPISRI GRYFILPPPP CNIFWAELLG VISAINLGIE
KGTKRIFVHS DNRNVVDLFN SHAPSKIVRP LFRHCVMRIV EAKVDVKVAH VSAEFNSEAD
NLSRIKTILT PEKSDILCHA INGTSISYLH INSSLSSGGQ VANLASLDPS FRQWLNPNRQ
GSA
//
