ID F4S874_MELLP Unreviewed; 585 AA.
AC F4S874;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Postreplication repair E3 ubiquitin-protein ligase RAD18 {ECO:0008006|Google:ProtNLM};
GN ORFNames=MELLADRAFT_94864 {ECO:0000313|EMBL:EGF99138.1};
OS Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf
OS rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Melampsoraceae; Melampsora.
OX NCBI_TaxID=747676 {ECO:0000313|Proteomes:UP000001072};
RN [1] {ECO:0000313|Proteomes:UP000001072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=98AG31 / pathotype 3-4-7 {ECO:0000313|Proteomes:UP000001072};
RX PubMed=21536894; DOI=10.1073/pnas.1019315108;
RA Duplessis S., Cuomo C.A., Lin Y.-C., Aerts A., Tisserant E.,
RA Veneault-Fourrey C., Joly D.L., Hacquard S., Amselem J., Cantarel B.L.,
RA Chiu R., Coutinho P.M., Feau N., Field M., Frey P., Gelhaye E.,
RA Goldberg J., Grabherr M.G., Kodira C.D., Kohler A., Kuees U.,
RA Lindquist E.A., Lucas S.M., Mago R., Mauceli E., Morin E., Murat C.,
RA Pangilinan J.L., Park R., Pearson M., Quesneville H., Rouhier N.,
RA Sakthikumar S., Salamov A.A., Schmutz J., Selles B., Shapiro H.,
RA Tanguay P., Tuskan G.A., Henrissat B., Van de Peer Y., Rouze P.,
RA Ellis J.G., Dodds P.N., Schein J.E., Zhong S., Hamelin R.C.,
RA Grigoriev I.V., Szabo L.J., Martin F.;
RT "Obligate biotrophy features unraveled by the genomic analysis of rust
RT fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:9166-9171(2011).
CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}.
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DR EMBL; GL883163; EGF99138.1; -; Genomic_DNA.
DR RefSeq; XP_007417578.1; XM_007417516.1.
DR AlphaFoldDB; F4S874; -.
DR STRING; 747676.F4S874; -.
DR EnsemblFungi; EGF99138; EGF99138; MELLADRAFT_94864.
DR GeneID; 18937041; -.
DR KEGG; mlr:MELLADRAFT_94864; -.
DR VEuPathDB; FungiDB:MELLADRAFT_94864; -.
DR eggNOG; KOG0287; Eukaryota.
DR HOGENOM; CLU_466216_0_0_1; -.
DR InParanoid; F4S874; -.
DR OrthoDB; 6177at2759; -.
DR Proteomes; UP000001072; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006301; P:postreplication repair; IEA:InterPro.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039577; Rad18.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR14134; E3 UBIQUITIN-PROTEIN LIGASE RAD18; 1.
DR PANTHER; PTHR14134:SF2; E3 UBIQUITIN-PROTEIN LIGASE RAD18; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00734; ZnF_Rad18; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 4: Predicted;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001072};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 32..89
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 247..274
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 144..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 64765 MW; EEFAF36B63542ED7 CRC64;
MRLQEEIESV SAPEDFLPNF QCLSALDTSL RCPICKDFFE APVLIHIPKC CHTFCSVCIR
ACFNQTLNSK IGSAGLGGVG NSQRCPICQT EAHEEKIKPV PALETVVTNW QEARSEILNM
VSQADRVKSL LQSANNRLPL LASGSTSQAA QLPEASNSSS SKLPEPRMIP DKRKAESLES
QGTSSGMRVT RSSHQAPEVR DTSGGSLTNT QASKKRKTKD KRPSKAVSDS DSDIEMITGD
LNNPAAMLPC PVCNRLLRNS DMNSHLDKCL AGTGNKAEIR KGANPNVPEK KIPLPHFKSL
KMKDFKALLQ QHHLSCDGTT DTMTRRLNRY ILLHNASLDS ERVHRKSLKE IRDEVDKWES
LNDADDANRR KLSNNNSDFA VQQIVGKRKI TITSEEEYLK KNKEQFAHLT TQAASTMKKT
VQPVNDEEAI ETSEPDDPTI GASETDRTLA TPEADDQTID IAEPNDQTVG TAENVQTLAA
PEDDKQILDT VEHTDHLEQA EVEISSKVIP QTCDNHQLDN HQQLQEPTSL PPVLPRSSIT
HNPQIDPAIV ALNQLQPRRS EDESMDHELH LSFTGSEHPI QTQNT
//
