ID F4S8K1_MELLP Unreviewed; 574 AA.
AC F4S8K1;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN ORFNames=MELLADRAFT_94935 {ECO:0000313|EMBL:EGF99004.1};
OS Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf
OS rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Melampsoraceae; Melampsora.
OX NCBI_TaxID=747676 {ECO:0000313|Proteomes:UP000001072};
RN [1] {ECO:0000313|Proteomes:UP000001072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=98AG31 / pathotype 3-4-7 {ECO:0000313|Proteomes:UP000001072};
RX PubMed=21536894; DOI=10.1073/pnas.1019315108;
RA Duplessis S., Cuomo C.A., Lin Y.-C., Aerts A., Tisserant E.,
RA Veneault-Fourrey C., Joly D.L., Hacquard S., Amselem J., Cantarel B.L.,
RA Chiu R., Coutinho P.M., Feau N., Field M., Frey P., Gelhaye E.,
RA Goldberg J., Grabherr M.G., Kodira C.D., Kohler A., Kuees U.,
RA Lindquist E.A., Lucas S.M., Mago R., Mauceli E., Morin E., Murat C.,
RA Pangilinan J.L., Park R., Pearson M., Quesneville H., Rouhier N.,
RA Sakthikumar S., Salamov A.A., Schmutz J., Selles B., Shapiro H.,
RA Tanguay P., Tuskan G.A., Henrissat B., Van de Peer Y., Rouze P.,
RA Ellis J.G., Dodds P.N., Schein J.E., Zhong S., Hamelin R.C.,
RA Grigoriev I.V., Szabo L.J., Martin F.;
RT "Obligate biotrophy features unraveled by the genomic analysis of rust
RT fungi.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:9166-9171(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; GL883165; EGF99004.1; -; Genomic_DNA.
DR RefSeq; XP_007417696.1; XM_007417634.1.
DR AlphaFoldDB; F4S8K1; -.
DR STRING; 747676.F4S8K1; -.
DR EnsemblFungi; EGF99004; EGF99004; MELLADRAFT_94935.
DR GeneID; 18937071; -.
DR KEGG; mlr:MELLADRAFT_94935; -.
DR VEuPathDB; FungiDB:MELLADRAFT_94935; -.
DR eggNOG; KOG1325; Eukaryota.
DR HOGENOM; CLU_014602_1_0_1; -.
DR InParanoid; F4S8K1; -.
DR OrthoDB; 1826981at2759; -.
DR Proteomes; UP000001072; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF33; LYSOPHOSPHOLIPASE 1-RELATED; 1.
DR Pfam; PF01735; PLA2_B; 2.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, ECO:0000256|PROSITE-
KW ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000001072};
KW Signal {ECO:0000256|RuleBase:RU362103}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT CHAIN 22..574
FT /note="Lysophospholipase"
FT /evidence="ECO:0000256|RuleBase:RU362103"
FT /id="PRO_5005129571"
FT DOMAIN 34..569
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
SQ SEQUENCE 574 AA; 62616 MW; 20E975E645C5C4B4 CRC64;
MLSYFYITLL ILFSSTLICH TQTPAHSYAP IRTKCPSGSF MRYAGTVERR NQRLGDKEAY
YMEQRRQKVI PGAYRAYLSN VENSLRSRSR RLPRYVSKIL RGDNIDRPHV SVAVSGGGLR
ASYFGAGVLN ALDGRNSTSV KVGTGGLLQA FDYITGLSGA ACLVMSLAQA NFPDMYELSL
GPRDPRVVPE ESDAFIGSTR GWLTDISYIT PGALNLAQDG LWWAEISGDV EEKAAAGFKV
SLADMYARIL AYHYVNGTSH ENYFDPGAPH GQAETLSSLA RAVPTLRNYS QPLALITSIA
ESPGEGRDNI LQGAAVPITN NQYEFSMFEV GSWDSNLATF IDTAYLGSQP GRKDCVKNYD
NLGFMVAASA NVLKKADNLL GALSTKGYFP ILPRIEGFLS LVPNPFKENL PFAPLLVPAR
KVDVILALDA SDDLDMGYPT GDALLATAQR SRIFPNKAYP FPDVKNVSRL HRTRPSFVGC
TDLPGTPLII YIPNAPPVPK VQTAALELSR ATSLAVLDSS TQLAFTKDPL WSGCLACAVV
DRARARAKKR RVGLCADCFS RYCYDGQAGK YTDV
//
