ID F4WAY9_ACREC Unreviewed; 3800 AA.
AC F4WAY9;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|EMBL:EGI68609.1};
GN ORFNames=G5I_02710 {ECO:0000313|EMBL:EGI68609.1};
OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS echinatior).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Acromyrmex.
OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN [1] {ECO:0000313|EMBL:EGI68609.1}
RP NUCLEOTIDE SEQUENCE.
RA Nygaard S., Zhang G.;
RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT adaptations to social evolution and fungus farming.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR EMBL; GL888056; EGI68609.1; -; Genomic_DNA.
DR STRING; 103372.F4WAY9; -.
DR EnsemblMetazoa; XM_011051098.1; XP_011049400.1; LOC105143081.
DR eggNOG; KOG0889; Eukaryota.
DR InParanoid; F4WAY9; -.
DR Proteomes; UP000007755; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000007755};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2609..3188
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3445..3764
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3768..3800
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 3202..3233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3209..3233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3800 AA; 435287 MW; 4558AB3454AFA1D9 CRC64;
MNTYRSYVTM LADPVSKDEL KLKAAQELSE NFEIIMCSSQ YAGFLDHMMK IFMKILQEGE
PHFISEYNIQ QVRKLILEMI HRLPSNEYLR PYVRQILTLI FKLLETDNEE NVLVCLRIII
DLHKQYKPTF NPEIQYFLQF VKSVYSELPK NLSKIFEPRP PLRVKDLSEI NIEALLKETF
TITAIQSEKK AADGTVVTYN LIPKAVLSLK VLQELPIIVV LLNQLYKQNV HQDVSDFVPI
VITTISLQPS LQHRTSPGFN KEVFVDFMGA QVKTLSFLAY VMRFYQDLIS QNSTMLVKGI
LGLFTLCPME VAHLRKELVI ASRHILATDL RNHFIPHMEI FFNEDIFIGH GWTAHEALRP
LAYSTLADLV HHVRLQLPLS DVSRAVHLYG KNLLDQTLPT AVQMVSCKLL MNLVDTVRQR
SDAENSTQGR ELLIRILLVF VLKFKTIAKI YIPILRNKTK QLRPVIADNT TEDTKPCLDV
SEEKEPPKSK FGFPTSQAMS YNVADYRNLV KSLVHGTKAI TSNCINNRNN EVPQTNQLQP
KETLIYIQLV KWALPALDIY TIGPPAIGVP AQPGRPMQSQ TIRTREEKEV LDLFGNVFTQ
MNPQTFQEIF SVSIDYMVER IFKNCALQII GSSFLSSHTV SSTFATILVE YLLERMSEMG
SNVERSNLYL KLFKLVFGSV SLFPAENEHM LRPHLNLIVN RAMELAMSAK EPYNYFLLLR
ALFRSIGGGS HDLLYQEFLP LLPNMLEGLN RLQSGLHRQH MKDLFVELCL TVPVRLSSLL
PYLPMLMDPL VSALNGSYCL VSQGLRTLEL CVDNLQPDFL YEHIQPIRAE LMQALWRTLH
NSNDQGVVAF RVLGKFGGGN RRMMIEPQKL EYNDRETNSP NVIVYFQGLS QPIDFPMEKV
IEAAFNALKS NTTDVFYRKQ CWEIIYCYLA ASLRMDDAAY LWYDLFTHPS FKEGEIPPQQ
GPHYKCFDTV ARNVQQTALT GMFVAVEIKE LRPSVLTTVV AVVRHYTMIA IAQQAGLFSW
TDKEIRKDMQ GQDPFVLIDA LAVIMGHDER ELYKAGYLTL VLILETATNI LGSKERACQL
PFMEYLAERM CSLCYERAWY AKLGGCIAIK FLFERMATKW VLNHLFVFLK ALIFVMMDLT
DEVSNGAIDM AKENLEKMLR VCVNPGIQEG NMELIEAQNK SLYEVTRELV KQVTSPHTIV
REQAMASIRQ LAEIQNKSVT EVMEPHKEVL ADVIPPKKHL LRHQPTNAQI GLMDGNTFCT
TLNPRLFTID LTIMEHKIFF QEVVGICDAD EATLNKFACY KSISNLMPVR KSALRALAAC
HYIVGYREKI LAVLYRALER PHAELQETAF ECMKTFIAGY QLDMESVHTM MRPMLLTLGD
HRNLSLNCVR RLSYLTQLFP STFSVTLCEQ MLQHVKKFLE NLIQSHKGIS KSGENEQKIT
IIIGIYHDIP ASLPKFNDAL CRLILQTEKS LLVEVSNPFK EPLMKCLLRY PTDALNLFLH
DSNIKDQQWS RYLEYLISHK DGKPFRDILH NSTARLVTML LAHSQTNSSL THMEKNEVQY
RAIKIIGILI KYDEQWLSTQ NQLVGALKQI WYNDDYQALH KKVEGVEYCH WKEPKHIVKI
LLHYFRHQPN DIDLLFQLLR ATCDRFVPDF QFLRDFLENT VAQEYTVEWK RSAFFRFVEH
FPTNNMSQEL KANVLQLIII PCFAVSFERG EGTKLVGGAP MPYQDNPENV VSVFISKIID
PDNPFGSADC VRISLLQFSC LLVEQASQHI HDVTNKRQGN KLRRLMTFAW PCLLGKNCVD
PTTRYHGHLL LSHIIAKFAI HKRIVLQVFH SLLKAHAVDA RNVVRQALEI LTPAMPVRME
DGNTMLTHWT KKIIVEEGHS MQQLSHILQL VVRHYKVYYP VRHHLVQHIV NSVQRIGCTP
TATIEHRRLA VELAEVIIKW ELYRIKEEAE TTTESNRVTV GQPSCLKRAI IDDPSGKRLS
SQTPSNNSPV PLILPRMEPG STKPIERAHA DAVLNFLLRL ACQVNDVTTI HGNPGEQLSR
RCVALLKMAL KPDVWVAEHC DLKLSWLDKV LSSVESSQPN YGNISMALEV LTFLLGVMKR
EQILVSFKLL QRGIGSCIAS SNTKIIRLVH GLLSRLMTIF PAELASTNMT PKYEELDTLY
TTVSRFIAEG LATYEKTTTA TPSSLFGTLM MLKAACTNNP SYVDRLITPF MKVLHKMAKE
HLHSTQTEAN PVTSELLILS LDLVKNRVAV MGVDMRKSFI GTILVGLIEK TQDVKVMKAI
TKILEEWMKN KTTIAMNQTP SLREKSILLV KMMQYVEKRF PDDLELNRQF LELVNYVYRD
ETLKMTELSN KLEQAFLAGL RCIQPQVRTK FFEVFDNSMK KRLVDRILYI IVSQNWEHIG
PHYWIKQCIE LLLATVNPST LVQITNEDLL LPSITSIMQG GMEKESKDQT HFVCRIGRTD
EEPPDKIPEG DSKDTFLEMD AWMSNLSDST SITATSEEIF EKPSLTQMIN KQIQFMENAK
KIKTEQLLLA TAQLCHMDTE LAERVWLDMF PRIWSILEES HINSISMEIV PFIASGAHVI
QKDCHPSALG TFLEAMAHCK PPVAIPPPVM KYVGRSHNVW HRITLSLEQM GGEMTAEGNG
GNMKNRGELD LYRSPDDVEQ VECVTPYYEV MHMLSEMYSL LCEEDMWSGL WQKRPAHYKE
TLHAIALEQQ GFFEQAQGAY EVCMSKFRQD YPSGPAPYHL NVEMLLWEKH WERTVKEQNQ
WEILLELGSQ NNYKNPFLVL DSAWRIPNWP VMKEILTQLE HNCPREISWK LSLYRGFVTL
CNSEDQHLST IERFVELAST QCLREWRRLP RIVSHVHQPL LQAAQQIMEL QEAMQIHQGL
LHGRSNSLHD MKAIVKTWRN RLPVIADDLS HWSDIFTWRQ HHYTFISNHY DSQQDQTINH
SLLGVHASMQ AIIHFGKISR KQNLCGVCLD SLAKIYTIPT SVPMVDCFQK IRQQVKCYLQ
MATMGGQNEL QEGLEVLDST NMGYFTKEMI AEFYALKGML QSQLGRSDDA NKSFSAATQL
HDTLVKAWSL WGDYLENIFI RDARQISIGI NALVCFLHAC RHQNESKSRK YIAKILWLLT
YDDDKCSLME TVDKYAVGVP AIQWLPWVPQ LLMYLVRNEG TVILNLLSQV GRMFPQAVYC
SARTLYLTLK IEQRERYKSG ELAADKSQDG VENRNSTTGN VTQQGTSETS HTVRATAPMW
RCSKIMHMQR EIHPTVLSSL EGIVDQMVWI RETWYEEVLK QLRQGLTKCY AIAFENRRAV
SEATITPHTL NFIKKLVSTF GIGIENISSS QNMSNSFSSA ASESLARRAQ ATVQDPVFQK
MKSQFTSDFD FTVPGAKLLH NLISKLKKWI KILEEKTKQL PKSFLIEEKC RFLTNFSLKT
AEVELPGEFL IPRHSHYSVK IAKFVPRVEV VQRHNMAARR LRIRGHNGRL YPYLVVNDAG
LGDARREERL LQLLRMLNHY LTKQKETSRR FLHFTVPRLV AVSPQMRLVE DNPAAISLLD
IYKQGCAKLG MEHDAPIARY YEKLAAVQAR GAQASHQVLR DILKEVQTSM VSKTLLKDWA
LKTFPGATDY WTFRKMFTLQ LSLTCFAEYV LHLTRHNPDM MYVHQDSGLI NIAYFKFDID
DTSGELDANR PVPFRLTPNI FEFITTIGVC GPLTASAIAT ARCLVQPTFQ LHAILRAILR
DEVIATHKRQ EDAEGTSPDP TDPKGELLIT MVTRAVTAIV TRLNSLANFD GIDSKVSTLV
AAANSHDNLC RMDPSWHPWL
//
