ID F4WZT4_ACREC Unreviewed; 996 AA.
AC F4WZT4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Receptor-type tyrosine-protein phosphatase N2 {ECO:0000313|EMBL:EGI60359.1};
GN ORFNames=G5I_11543 {ECO:0000313|EMBL:EGI60359.1};
OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS echinatior).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Acromyrmex.
OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN [1] {ECO:0000313|EMBL:EGI60359.1}
RP NUCLEOTIDE SEQUENCE.
RA Nygaard S., Zhang G.;
RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT adaptations to social evolution and fungus farming.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; GL888480; EGI60359.1; -; Genomic_DNA.
DR AlphaFoldDB; F4WZT4; -.
DR STRING; 103372.F4WZT4; -.
DR EnsemblMetazoa; XM_011064652.1; XP_011062954.1; LOC105151115.
DR eggNOG; KOG0793; Eukaryota.
DR InParanoid; F4WZT4; -.
DR Proteomes; UP000007755; Unassembled WGS sequence.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF4; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|EMBL:EGI60359.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007755};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..996
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003319152"
FT TRANSMEM 584..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 706..966
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 885..957
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 639..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 113813 MW; 5E7BB4BE1C016893 CRC64;
MNSLGTSMGR KRWQGGLELL VLCILVLHHV VVLADGDVGC LFSEDICDSQ TEKCFDDLAF
GKCIPQYTNL ENENLYQYNL DIDELELLHS MRLQLMRLIE SNGYNWKHPF TQCIVQTSLH
NLRYGQNDAR DFRLCEYLKK PRLNEQQDGF IDEMVPAVAI LRISTDNENP ESNLADVLYR
PTDIEDRSGY MKWRGDENNQ ASINNEKYDN EYRNSMNMRE QFYPSRTRRF SFIDDYQNDV
TESLEDTLRD ETLPEDDEED ENVSDTQLLS ANLEFLQNEK SPDYTLLKPS SETNERAFSR
KYKHRKKPLR FEFSDTDVKK GVMGRDEDLD YGNSEINEEN SANIERSDVD TSSKIREMYT
EGGVVRPRKY KITSDASGTL YDEIYDDDLD ALLWRRELAG FKRRERLDVK KPGPPFSTNN
YAFKTQSPAT LLDKDYSEVD NQNNNNEIYA PLTKKELHSN MYRTSDDRSE TYKNVDLDYV
YIEFEQEFHT WLEGEHVVNK VEELLGLPSG TLKDIRVGRA EVTFKVIQND KNYNATEVVN
NIDNIRGKLQ NALGIEVIRA GIGDKTKLPA TLEVARESDT SSSFFGALVA AGVAAAVAAA
VVTLIIARRH AKCRAKLAGL ATPDPEASKD YQDLCRARMQ AKQPSEKLES PRITSLTREN
ESNNLSSNRS STSSWGEEPA LTNMDISTGH MVLRYMEDHL KNKDRLDQEW GALCAYEAEP
SSTEIAESEA NVKQNRPNAA LPYDHSRVVL NDLANANNSD YINASTITDH DPRNPAYIAT
QGPLPQTTAD FWQLVWEQGS VVIVMLTRLT EEGRAMCHRY WPEEGSELYH IYEVHLVSEH
FWCDDYLVRS FYLKNLRTCE TRTVTQFHFL SWPENSVPYS TKALLEFRRK VNKSYRGRSC
PIVVHCSDGA GRTGTYCLID MVLNRMTKGA KEIDIAATLE HIRDQRPDMV ATKQQFEFVL
MAVAEEVHAI LKALPVSSNE KSVTATGSSP PTKSEQ
//
