ID F4X3X2_ACREC Unreviewed; 962 AA.
AC F4X3X2;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Insulin-degrading enzyme {ECO:0000313|EMBL:EGI58919.1};
GN ORFNames=G5I_13035 {ECO:0000313|EMBL:EGI58919.1};
OS Acromyrmex echinatior (Panamanian leafcutter ant) (Acromyrmex octospinosus
OS echinatior).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC Formicidae; Myrmicinae; Acromyrmex.
OX NCBI_TaxID=103372 {ECO:0000313|Proteomes:UP000007755};
RN [1] {ECO:0000313|EMBL:EGI58919.1}
RP NUCLEOTIDE SEQUENCE.
RA Nygaard S., Zhang G.;
RT "The genome of the leaf-cutting ant Acromyrmex echinatior suggests key
RT adaptations to social evolution and fungus farming.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; GL888624; EGI58919.1; -; Genomic_DNA.
DR AlphaFoldDB; F4X3X2; -.
DR STRING; 103372.F4X3X2; -.
DR MEROPS; M16.A08; -.
DR eggNOG; KOG0959; Eukaryota.
DR InParanoid; F4X3X2; -.
DR Proteomes; UP000007755; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000007755};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 33..164
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 197..374
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 380..661
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 676..848
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 962 AA; 112902 MW; 0A02AFD27CED762F CRC64;
MSTERVEKRC DDIIKSQNDD RLYRGLVLTN KMKVILISDP TTDKSAAAMD INVGSMCDPD
DLPGLAHFCE HMLFLGTKKY PQQNDYNKFL SQNGGMSKAI THLDHTIYYF DVSFEKLKGA
LDRFAQFFLT PLFTENLIEL ELNAINSEHE KNLADDSQRV NHLIKSSANS HHPFSKFSTG
NRESLDTIPK QKGINVRNKL LEFYEKYYSA NIMSLSVLGK ESLDELENMV VDLFCEVRNK
EIQVPTWPEH PFKDEHFRTM WYIVPKTYIR SLNIEFPLPD MHRQSSPEHY VSYLLQHERK
GSLLSVLRAK KWGNYLKSTQ RAQSARGFSI FNIFIDLTKK GIKHIEDIIL LVFQYINMLK
LEEPSKWIYD EYRDIDNIKF YFKEKSSPRT HVKFTVRALQ EFPMNEILCA CVNPEWRPDL
IKKIIGYLTP QNVRIYITAK EYENIADEIE SWYGTKYKKV KVSKKIMDMW NSPGFNDDLK
LPPKNEFIAT IFDIKPQINV VKFPIILKDT SFVKLWYKKD DEFLVPKAKM IFDFFIPFAH
VDPLSCNFTY MFINLFRESL NEYTYAANLA GLQWELNSFK YGITLSIDGY DDKQHVLLEK
IMDRMINFEV DPKRFEILKK KYIWKLTSEG LTFKLLHEHA INYLVNLLEG QQWLREELLE
ATTYLDVRGF KRHILQLFNK MHIQCLIYGN VTEMEAIDIL ELIEFKLMTG VPNIIPLLEQ
KLELSREIKL ENGCHFLFEV KNDLYKSSCT IVYYPTGLQS IESNMLLELL AQIIAEPCFN
TLKTKEQLDY IVLSDIHRSN KAQGLRIIVQ SDKHPQYVEK RINLFLHSML NHISTMTEEQ
FEENKKALAV RLGKPNRLSA RCILYWNEII NQQCNFDRVN IEAAYLKTIS QQQLLNFFKD
MAKLVVSVWS LVTATEIVRT KRLNWPATVW RFPQSSHQPS SSSLLVLSWT RSILRDLIEL
PR
//