ID F5GUC9_CAEEL Unreviewed; 639 AA.
AC F5GUC9;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Regulator of G-protein signaling egl-10 {ECO:0000313|EMBL:CCA65559.1};
GN Name=egl-10 {ECO:0000313|EMBL:CCA65559.1,
GN ECO:0000313|WormBase:F28C1.2b};
GN ORFNames=CELE_F28C1.2 {ECO:0000313|EMBL:CCA65559.1}, F28C1.2
GN {ECO:0000313|WormBase:F28C1.2b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCA65559.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCA65559.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCA65559.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284605; CCA65559.1; -; Genomic_DNA.
DR RefSeq; NP_001256419.1; NM_001269490.1.
DR AlphaFoldDB; F5GUC9; -.
DR SMR; F5GUC9; -.
DR EPD; F5GUC9; -.
DR PeptideAtlas; F5GUC9; -.
DR EnsemblMetazoa; F28C1.2b.1; F28C1.2b.1; WBGene00001179.
DR GeneID; 179707; -.
DR AGR; WB:WBGene00001179; -.
DR WormBase; F28C1.2b; CE45947; WBGene00001179; egl-10.
DR OMA; PWINDTV; -.
DR OrthoDB; 22856at2759; -.
DR PhylomeDB; F5GUC9; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00001179; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; F5GUC9; baseline.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0043005; C:neuron projection; IDA:WormBase.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; IMP:WormBase.
DR GO; GO:0007631; P:feeding behavior; IMP:WormBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0040017; P:positive regulation of locomotion; IMP:WormBase.
DR GO; GO:0046662; P:regulation of egg-laying behavior; IMP:WormBase.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IGI:WormBase.
DR GO; GO:0007622; P:rhythmic behavior; IMP:WormBase.
DR CDD; cd04450; DEP_RGS7-like; 1.
DR CDD; cd00068; GGL; 1.
DR CDD; cd08705; RGS_R7-like; 1.
DR Gene3D; 1.10.1240.60; -; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR047016; RGS6/7/9/11.
DR InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR InterPro; IPR040759; RGS_DHEX.
DR InterPro; IPR034483; RGS_Egl-10.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45746; LP21163P; 1.
DR PANTHER; PTHR45746:SF6; LP21163P; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00631; G-gamma; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF18148; RGS_DHEX; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00049; DEP; 1.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:F5GUC9,
KW ECO:0007829|PeptideAtlas:F5GUC9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT DOMAIN 37..112
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 337..390
FT /note="G protein gamma"
FT /evidence="ECO:0000259|PROSITE:PS50058"
FT DOMAIN 421..537
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 253..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 639 AA; 72104 MW; 17B1F78EB74B365F CRC64;
MALPRLRVNA SNEERLVHPN HMVYRKMEML VNQMLDAEAG VPIKTVKSFL SKVPSVFTGQ
DLIGWIMKNL EMTDLSDALH LAHLIASHGY LFQIDDHVLT VKNDGTFYRF QTPYFWPSNC
WDPENTDYAV YLCKRTMQNK AHLELEDFEA ENLAKLQKMF SRKWEFVFMQ AEAQYKVDKK
RDRQERQILD SQERAFWDVH RPVPGCVNTT EVDFRKLSRS GRPKYSSGGH AALAASTSGI
GCTQYSQSVA AAHASLPSTS NGSATSPRKN DQEPSTSSGG ESPSTSSAAA GTATTSAPST
STPPVTTITA TINAGSFRNN YYTRPGLRRC TQVQDTLKLE IVQLNSRLSK NVLRTSKVVE
NYLAYYEQRR VFDPLLTPPG SQADPFQSQP NPWINDTVDF WQHDKITGDI QTRRLKLWED
SFEELLADSL GRETLQKFLD KEYSGENLRF WWEVQKLRKC SSRMVPVMVT EIYNEFIDTN
AATSPVNVDC KVMEVTEDNL KNPNRWSFDE AADHIYCLMK NDSYQRFLRS EIYKDLVLQS
RKKTTFTSLI ARKASRRIGS TMSRSSQSNK TLHASASLGS ALSGHGSSTS SMLTAGGAAS
SQNLLLAPPQ HHLYVPSLSL SYTHTQHSLP MKCRMNVVF
//