ID F5GWQ8_HUMAN Unreviewed; 518 AA.
AC F5GWQ8;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=Clusterin {ECO:0000256|RuleBase:RU000629};
GN Name=CLUL1 {ECO:0000313|Ensembl:ENSP00000441726};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000441726, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000441726, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000441726}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR EMBL; AP001178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001275965.1; NM_001289036.1.
DR AlphaFoldDB; F5GWQ8; -.
DR SMR; F5GWQ8; -.
DR MassIVE; F5GWQ8; -.
DR PeptideAtlas; F5GWQ8; -.
DR ProteomicsDB; 24187; -.
DR Antibodypedia; 21905; 103 antibodies from 21 providers.
DR DNASU; 27098; -.
DR Ensembl; ENST00000540035.5; ENSP00000441726.1; ENSG00000079101.17.
DR GeneID; 27098; -.
DR KEGG; hsa:27098; -.
DR UCSC; uc010wys.3; human.
DR CTD; 27098; -.
DR HGNC; HGNC:2096; CLUL1.
DR VEuPathDB; HostDB:ENSG00000079101; -.
DR OrthoDB; 5320180at2759; -.
DR BioGRID-ORCS; 27098; 17 hits in 1141 CRISPR screens.
DR ChiTaRS; CLUL1; human.
DR GenomeRNAi; 27098; -.
DR Proteomes; UP000005640; Chromosome 18.
DR Bgee; ENSG00000079101; Expressed in pigmented layer of retina and 124 other cell types or tissues.
DR ExpressionAtlas; F5GWQ8; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF2; CLUSTERIN-LIKE PROTEIN 1; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 78..289
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT DOMAIN 290..512
FT /note="Clusterin C-terminal"
FT /evidence="ECO:0000259|SMART:SM00035"
SQ SEQUENCE 518 AA; 60135 MW; C1289326F00B6193 CRC64;
MRTWDYRWSL ALVAQTGVHC CNLSSLQPLP PRFKRFSCLS LSSGWDYSNS GNMKPPLLVF
IVCLLWLKDS HCAPTWKDKT AISENLKSFS EVGEIDADEE VKKALTGIKQ MKIMMERKEK
EHTNLMSTLK KCREEKQEAL KLLNEVQEHL EEEERLCRES LADSWGECRS CLENNCMRIY
TTCQPSWSSV KNKIERFFRK IYQFLFPFHE DNEKDLPISE KLIEEDAQLT QMEDVFSQLT
VDVNSLFNRS FNVFRQMQQE FDQTFQSHFI SDTDLTEPYF FPAFSKEPMT KADLEQCWDI
PNFFQLFCNF SVSIYESVSE TITKMLKAIE DLPKQDKAPD HGGLISKMLP GQDRGLCGEL
DQNLSRCFKF HEKCQKCQAH LSEDCPDVPA LHTELDEAIR LVNVSNQQYG QILQMTRKHL
EDTAYLVEKM RGQFGWVSEL ANQAPETEII FNSIQVVPRI HEGNISKQDE TMMTDLSILP
SSNFTLKIPL EESAESSNFI GYVVAKALQH FKEHFKTW
//
