ID F5GXL4_HUMAN Unreviewed; 234 AA.
AC F5GXL4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Pepsinogen A3 {ECO:0000313|Ensembl:ENSP00000440177.1};
DE SubName: Full=Pepsinogen A4 {ECO:0000313|Ensembl:ENSP00000442757.1};
GN Name=PGA3 {ECO:0000313|Ensembl:ENSP00000440177.1};
GN Synonyms=PGA4 {ECO:0000313|Ensembl:ENSP00000442757.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000440177.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000440177.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000440177.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AP000437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP003037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 24458; -.
DR Antibodypedia; 28068; 223 antibodies from 19 providers.
DR Antibodypedia; 28082; 145 antibodies from 21 providers.
DR Ensembl; ENST00000537932.5; ENSP00000442757.1; ENSG00000229183.10.
DR Ensembl; ENST00000543125.5; ENSP00000440177.1; ENSG00000229859.10.
DR UCSC; uc058bxx.1; human.
DR HGNC; HGNC:8885; PGA3.
DR HGNC; HGNC:8886; PGA4.
DR VEuPathDB; HostDB:ENSG00000229183; -.
DR VEuPathDB; HostDB:ENSG00000229859; -.
DR GeneTree; ENSGT00940000155036; -.
DR HOGENOM; CLU_013253_6_1_1; -.
DR ChiTaRS; PGA3; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000229183; Expressed in right uterine tube and 93 other cell types or tissues.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF22; PEPSIN A-3-RELATED; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 1..231
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT REGION 22..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 114..118
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 234 AA; 24599 MW; 97FFFBC55D953DD1 CRC64;
MVSGNNSDSA HCIGTGLRGK ETTLVTPQDS PRKCPIKGSP EEATADGHTN GRTKKFMSSP
LTFHSDDQSG SVVIFGGIDS SYYTGSLNWV PVTVEGYWQI TVDSITMNGE AIACAEGCQA
IVDTGTSLLT GPTSPIANIQ SDIGASENSD GDMVVSCSAI SSLPDIVFTI NGVQYPVPPS
AYILQSEGSC ISGFQGMNLP TESGELWILG DVFIRQYFTV FDRANNQVGL APVA
//
