ID F5H3B6_HUMAN Unreviewed; 450 AA.
AC F5H3B6;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Shroom family member 2 {ECO:0000313|Ensembl:ENSP00000415229.3};
GN Name=SHROOM2 {ECO:0000313|Ensembl:ENSP00000415229.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415229.3, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000415229.3, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000415229.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the shroom family.
CC {ECO:0000256|ARBA:ARBA00006469}.
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DR EMBL; AC002365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF458973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001307593.1; NM_001320664.1.
DR RefSeq; XP_016884981.1; XM_017029492.1.
DR RefSeq; XP_016884983.1; XM_017029494.1.
DR AlphaFoldDB; F5H3B6; -.
DR SMR; F5H3B6; -.
DR MassIVE; F5H3B6; -.
DR PeptideAtlas; F5H3B6; -.
DR ProteomicsDB; 26222; -.
DR Antibodypedia; 23655; 198 antibodies from 26 providers.
DR DNASU; 357; -.
DR Ensembl; ENST00000418909.6; ENSP00000415229.3; ENSG00000146950.13.
DR GeneID; 357; -.
DR UCSC; uc004csv.3; human.
DR CTD; 357; -.
DR HGNC; HGNC:630; SHROOM2.
DR VEuPathDB; HostDB:ENSG00000146950; -.
DR GeneTree; ENSGT00940000155212; -.
DR HOGENOM; CLU_027693_0_0_1; -.
DR OrthoDB; 4120529at2759; -.
DR BioGRID-ORCS; 357; 18 hits in 776 CRISPR screens.
DR ChiTaRS; SHROOM2; human.
DR GenomeRNAi; 357; -.
DR Proteomes; UP000005640; Chromosome X.
DR Bgee; ENSG00000146950; Expressed in middle temporal gyrus and 150 other cell types or tissues.
DR ExpressionAtlas; F5H3B6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR014799; ASD2_dom.
DR InterPro; IPR027685; Shroom_fam.
DR PANTHER; PTHR15012; APICAL PROTEIN/SHROOM-RELATED; 1.
DR PANTHER; PTHR15012:SF8; PROTEIN SHROOM2; 1.
DR Pfam; PF08687; ASD2; 1.
DR PROSITE; PS51307; ASD2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Proteomics identification {ECO:0007829|EPD:F5H3B6,
KW ECO:0007829|MaxQB:F5H3B6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 152..445
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 198..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 240..295
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 198..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 50869 MW; 62F61A93CBEE9FE3 CRC64;
METSRSPSPQ FAPQKLTDKP PLLIQDEDST RIERVMDNNT TVKMVPIKIV HSESQPEKES
RQSLACPAEP PALPHGLEKD QIKTLSTSEQ FYSRFCLYTR QGAEPEAPHR AQPAEPQPLG
TQVPPEKDRC TSPPGLSYMK AKEKTVEDLK SEELAREIVG KDKSLADILD PSVKIKTTMD
LMEGIFPKDE HLLEEAQQRR KLLPKIPSPR STEERKEEPS VPAAVSLATN STYYSTSAPK
AELLIKMKDL QEQQEHEEDS GSDLDHDLSV KKELIESISR KLQVLREARE SLLEDVQANT
VLGAEVEAIV KGVCKPSEFD KFRMFIGDLD KVVNLLLSLS GRLARVENAL NNLDDGASPG
DRQSLLEKQR VLIQQHEDAK ELKENLDRRE RIVFDILANY LSEESLADYE HFVKMKSALI
IEQRELEDKI HLGEEQLKCL LDSLQPERGK
//
