ID F5HB26_HCMV Unreviewed; 561 AA.
AC F5HB26; A0A1D6WRZ0;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Tegument protein pp65 {ECO:0000313|EMBL:ACZ72826.1};
GN Name=UL83 {ECO:0000313|EMBL:ACZ72826.1};
OS Human cytomegalovirus (HHV-5) (Human herpesvirus 5).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Cytomegalovirus;
OC Cytomegalovirus humanbeta5.
OX NCBI_TaxID=10359 {ECO:0000313|EMBL:ACZ72826.1, ECO:0000313|Proteomes:UP000181469};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|Proteomes:UP000180981, ECO:0000313|Proteomes:UP000181469}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merlin {ECO:0000313|EMBL:ACZ72826.1};
RX PubMed=20679731; DOI=10.1172/JCI42955;
RA Stanton R.J., Baluchova K., Dargan D.J., Cunningham C., Sheehy O.,
RA Seirafian S., McSharry B.P., Neale M.L., Davies J.A., Tomasec P.,
RA Davison A.J., Wilkinson G.W.;
RT "Reconstruction of the complete human cytomegalovirus genome in a BAC
RT reveals RL13 to be a potent inhibitor of replication.";
RL J. Clin. Invest. 120:3191-3208(2010).
RN [2] {ECO:0000313|EMBL:AII79685.1, ECO:0000313|Proteomes:UP000181191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merlin {ECO:0000313|EMBL:AII79685.1};
RX PubMed=20410314; DOI=10.1099/vir.0.021931-0;
RA Prod'homme V., Sugrue D.M., Stanton R.J., Nomoto A., Davies J.,
RA Rickards C.R., Cochrane D., Moore M., Wilkinson G.W., Tomasec P.;
RT "Human cytomegalovirus UL141 promotes efficient downregulation of the
RT natural killer cell activating ligand CD112.";
RL J. Gen. Virol. 91:2034-2039(2010).
RN [3] {ECO:0000313|Proteomes:UP000180881, ECO:0000313|Proteomes:UP000181426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merlin {ECO:0000313|EMBL:AII79850.1};
RA Hsu J.-L., van Boomen D.J.H., Tomasec P., Weekes M.P., Antrobus R.,
RA Stanton R.J., Ruckova E., Sugrue D., Wilkie G.S., Davison A.J.,
RA Wilkinson G.W.G., Lehner P.J.;
RT "Plasma membrane profiling defines an expanded class of cell surface
RT proteins selectively targeted for degradation by HCMV US2 in cooperation
RT with UL141.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AII79517.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Merlin {ECO:0000313|EMBL:AII79517.1};
RA Davison A.J.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|ARBA:ARBA00004147}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. Virion tegument
CC {ECO:0000256|ARBA:ARBA00004535}.
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DR EMBL; GU179001; ACZ72826.1; -; Genomic_DNA.
DR EMBL; KM192298; AII79517.1; -; Genomic_DNA.
DR EMBL; KM192299; AII79685.1; -; Genomic_DNA.
DR EMBL; KM192300; AII79850.1; -; Genomic_DNA.
DR EMBL; KM192301; AII80009.1; -; Genomic_DNA.
DR EMBL; KM192302; AII80176.1; -; Genomic_DNA.
DR RefSeq; YP_081531.1; NC_006273.2.
DR SMR; F5HB26; -.
DR GeneID; 3077579; -.
DR KEGG; vg:3077579; -.
DR OrthoDB; 9854at10239; -.
DR Proteomes; UP000180881; Genome.
DR Proteomes; UP000180981; Genome.
DR Proteomes; UP000181191; Genome.
DR Proteomes; UP000181426; Genome.
DR Proteomes; UP000181462; Genome.
DR Proteomes; UP000181469; Genome.
DR GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR008649; Herpes_UL82/UL83.
DR Pfam; PF05784; Herpes_UL82_83; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
PE 4: Predicted;
KW Host nucleus {ECO:0000256|ARBA:ARBA00022562};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virion tegument {ECO:0000256|ARBA:ARBA00022580}.
FT REGION 389..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..448
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 561 AA; 62912 MW; 134FD1500DE40B32 CRC64;
MESRGRRCPE MISVLGPISG HVLKAVFSRG DTPVLPHETR LLQTGIHVRV SQPSLILVSQ
YTPDSTPCHR GDNQLQVQHT YFTGSEVENV SVNVHNPTGR SICPSQEPMS IYVYALPLKM
LNIPSINVHH YPSAAERKHR HLPVADAVIH ASGKQMWQAR LTVSGLAWTR QQNQWKEPDV
YYTSAFVFPT KDVALRHVVC AHELVCSMEN TRATKMQVIG DQYVKVYLES FCEDVPSGKL
FMHVTLGSDV EEDLTMTRNP QPFMRPHERN GFTVLCPKNM IIKPGKISHI MLDVAFTSHE
HFGLLCPKSI PGLSISGNLL MNGQQIFLEV QAIRETVELR QYDPVAALFF FDIDLLLQRG
PQYSEHPTFT SQYRIQGKLE YRHTWDRHDE GAAQGDDDVW TSGSDSDEEL VTTERKTPRV
TGGGAMASAS TSAGRKRKSA SSATACTAGV MTRGRLKAES TVAPEEDTDE DSDNEIHNPA
VFTWPPWQAG ILARNLVPMV ATVQGQNLKY QEFFWDANDI YRIFAELEGV WQPAAQPKRR
RHRQDALPGP CIASTPKKHR G
//
