ID F5HMC0_ANOGA Unreviewed; 1414 AA.
AC F5HMC0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=AGAP001935-PB {ECO:0000313|EMBL:EGK97442.1};
GN ORFNames=AgaP_AGAP001935 {ECO:0000313|EMBL:EGK97442.1};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EGK97442.1};
RN [1] {ECO:0000313|EMBL:EGK97442.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EGK97442.1};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EGK97442.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK97442.1};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EGK97442.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK97442.1};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EGK97442.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK97442.1};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EGK97442.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EGK97442.1};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGK97442.1}.
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DR EMBL; AAAB01008987; EGK97442.1; -; Genomic_DNA.
DR RefSeq; XP_003435971.1; XM_003435923.1.
DR GeneID; 1281190; -.
DR KEGG; aga:AgaP_AGAP001935; -.
DR VEuPathDB; VectorBase:AGAP001935; -.
DR HOGENOM; CLU_001626_3_0_1; -.
DR OrthoDB; 4538469at2759; -.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17094; FERM_F1_Max1_like; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22903:SF8; MAX-1A; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 537..631
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 645..753
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 788..1006
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1017..1333
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..117
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 128..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..169
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..198
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..483
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1414 AA; 154752 MW; 9EA15E4495827CAD CRC64;
MEQRLCDWPK SPNLTGPSPS PSSNPAAAAA AAGAQQAIAA AVGAGPPGTE QPPKGTDPVK
ISQLESAIEE QKQLRLQDAR QVGAKAAKIK EWVTNKLREL EEQNQLLREQ NIKCNQQLEL
LRNHIATQST RHSSVAPTQP VRTSLSLDVQ DVKRRSGRRR SESLDPPEHR SLHAGSSGSG
SHHHPHHHHH HHHHHHRRNL SMEPQELARD LAAAVDGLNL LPLSQQQPHQ SVAAPAQPQA
SGQGAHQHHP QPHHQHPAPP PPGMGASPGS DVDAVHDYAE IYTPSREKAP AWLKGLPSGG
SSTTTSDSVA DLGTPRPPTP PLHRFPSWEA KIYQVANDGL AGAGSNGAAG AGEEGESQDQ
ESGSGMTASV GGGGGGNSRS QTVSGGYCDI SVPVYATVKG RASQIRSMPF TGDSSDDSSD
GEDGHGAMLT CATSTHNSHN STSTDNTETS TSGSASSPSK SLKTSSSLSP AKRSGSESPK
NKGRAISELS FESGLSDDYA IPPDAVSTVD TTCMDASMPS LLMRTSYADS PNKKMETLEK
VGHLAKLGGK LKTWRKRWFV LKNGTLTYWK SQHDVNRKPQ GQIALDEACR INRADGASTF
EIDTGKKVYY LTADSNATMD DWIRVLQNVQ RRNATKLLLS RDDQKPTVQG WVTKVKNGHA
KKCWCVLLGK MFLYFKAPGE TNPLGQINMR DARVEEVEHV SDSDSEERED PAQSQARLTV
AIYPQQQGGP TYLILPGKQE RDNWLYHLTV VSGGGPNAGT QYEQLIQKLM ETDGDPNCVL
WRHPILLHTK DNITSPLTSL HSETLQAEAI KLFKSCQLFL SVAVNQPGID YHVVLAQNAL
QQCLDMPELQ SELICALIKQ TSRHTGQKLG VGVQVNKKLA KPARQLLLCA TQSLFTCDTQ
QGSVAQANGS SPTSIQAPTV PPIDCKSNPP SYTFIQGWQL LALAVSLFVP KNSRLLWYLK
LHLSRNADSK TDCGKYAAYC ERALERTMQN GGRETKPSRM EVLSILLKNP YHHSLPHAIP
VHMMNTTYQV VSFDGSTTIE EFHGTLAQEI GCRDATNGFT LFSDDPIEKD LEHYLDPQAK
LCDVISKWET ALREKGSGKF ENSRVIQLTY KNRLYWKHAA KLETEKERLL LCYQVNIQVV
QGRFPLSRDL ALELASLMAQ IDMGDFASDK SKTNSLQALD KFYPYRYRDA LNQEGLKELQ
ELLSAKWALL RGRSVLDCVR IYLTCARKWP FFGAALFQAK PRHSDQAMAW LAVSEDALSV
LELSSMATIA RYPYSSVMTF GGCQDDFMLV VSAEDTLQSA SNEQKLLFAM SKPKILEITL
LIADYMNALG HTLPGTPQMN TLTRNGSHRS IRSRALPGSL TGTPAHNTLN SHATHANNTL
TSHSHTLNSH VSHTLSSHGQ PDILKSTPDH QRHK
//
