ID F5IUY0_9BACT Unreviewed; 757 AA.
AC F5IUY0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=TGS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF9455_01280 {ECO:0000313|EMBL:EGK03030.1};
OS Dysgonomonas gadei ATCC BAA-286.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Dysgonomonas.
OX NCBI_TaxID=742766 {ECO:0000313|EMBL:EGK03030.1, ECO:0000313|Proteomes:UP000004913};
RN [1] {ECO:0000313|EMBL:EGK03030.1, ECO:0000313|Proteomes:UP000004913}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-286 {ECO:0000313|EMBL:EGK03030.1,
RC ECO:0000313|Proteomes:UP000004913};
RG The Broad Institute Genome Sequencing Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Pudlo N., Martens E.,
RA Allen-Vercoe E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Yandava C., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Dysgonomonas gadei ATCC BAA-286.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGK03030.1}.
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DR EMBL; ADLV01000015; EGK03030.1; -; Genomic_DNA.
DR AlphaFoldDB; F5IUY0; -.
DR STRING; 742766.HMPREF9455_01280; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_0_10; -.
DR Proteomes; UP000004913; Unassembled WGS sequence.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000004913}.
FT DOMAIN 412..473
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 682..755
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 757 AA; 86552 MW; 6E33B6F279EB9CB9 CRC64;
MFPYSKLMAK EDTHTQDDIL IEQEFNALID DYLKTNHRRK VEIITKAFLF AKEAHKGARR
RSGEPYILHP ISVARIVCGE IGLGSTSICA ALLHDVVEDT EYTVEDMKVL FGDKIAQIVD
GLTKISSGMF GENVSAQAEN FRKLLLTMSD DIRVILVKIA DRLHNMRTLG SMAPAKQYKI
AGETMYIYAP LAHRLGLFAI KTELEELSFK WENPEVYKDI QYKLQATYKI RSDVYQHFAK
PVVDKLNELG FKYEIRAREK SVYSIWNKMQ AKGVPFEEIY DIFAVRIIFE NEPGIDEKKR
CWDIYSVITD IYKLRPDRIR DWVSRPKANG YQALHLTVMG PDGQWIEIQI RSRRMDDIAE
KGFAAHWKYK EGKIEEDTEL DKWLKTIKEI LESPSPNAMD FLDTIKLNLY SQEIFVFTPK
GEIRTLAQGA TALDFAYDLH SDIGDHCIGA KVNHKLVPLS EKLNSGDQVE ILTSKSQVPK
YEWLGLVTTA KARTKIEYAL RKHKREVAKQ GEELLIKALE GTTIELTPAI MDQMLDYYQK
QTKEDLYYAI GNNDISLPQK IEKLLTLKKQ NSDNVLVKYM KQAFHAVKKA DKDKAEKPQE
YEQINPKKTY ILEEDSFNKN FRMPTCCNPI PGDKVFGYLN DDNEVDVHSI HCPVGLKLKA
SHGDKIVNLE WGSYTQFPFL TSIIVTGIDR MGMLNDITKV ITAGSLNIKG MNIESNDGVF
EGRIIVYVHD VNDLQTLCSR IAKIKGVKAV NRKQSGA
//
