ID F5LBY0_9BACL Unreviewed; 261 AA.
AC F5LBY0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Metallo-beta-lactamase domain protein {ECO:0000313|EMBL:EGL20130.1};
GN ORFNames=HMPREF9413_5599 {ECO:0000313|EMBL:EGL20130.1};
OS Paenibacillus sp. HGF7.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=944559 {ECO:0000313|EMBL:EGL20130.1, ECO:0000313|Proteomes:UP000003445};
RN [1] {ECO:0000313|EMBL:EGL20130.1, ECO:0000313|Proteomes:UP000003445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGF7 {ECO:0000313|EMBL:EGL20130.1,
RC ECO:0000313|Proteomes:UP000003445};
RA Durkin A.S., Madupu R., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Counteracts the endogenous Pycsar antiviral defense system.
CC Phosphodiesterase that enables metal-dependent hydrolysis of host
CC cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
CC {ECO:0000256|ARBA:ARBA00034301}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic CMP + H2O = CMP + H(+); Xref=Rhea:RHEA:72675,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58003,
CC ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00034221};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72676;
CC Evidence={ECO:0000256|ARBA:ARBA00034221};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3',5'-cyclic UMP + H2O = H(+) + UMP; Xref=Rhea:RHEA:70575,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57865,
CC ChEBI:CHEBI:184387; Evidence={ECO:0000256|ARBA:ARBA00034227};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70576;
CC Evidence={ECO:0000256|ARBA:ARBA00034227};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGL20130.1}.
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DR EMBL; AFDH01000008; EGL20130.1; -; Genomic_DNA.
DR RefSeq; WP_009671480.1; NZ_AFDH01000008.1.
DR AlphaFoldDB; F5LBY0; -.
DR OrthoDB; 9800940at2; -.
DR Proteomes; UP000003445; Unassembled WGS sequence.
DR CDD; cd16279; metallo-hydrolase-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR42663:SF6; HYDROLASE C777.06C-RELATED; 1.
DR PANTHER; PTHR42663; HYDROLASE C777.06C-RELATED-RELATED; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000003445}.
FT DOMAIN 37..228
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 261 AA; 29048 MW; A0CDE37DB1DB38CA CRC64;
MDVLTFFGTG DSMGVPRAYC DCGVCTEART TGVNRRLRSS ALLDTGTAEG SLLLDCGPNW
GLQMERAGLR DLRHVLITHA HYDHIGGLPE YADLCRWLGI RGKVYAAAEV VDRIRAIFPW
IDRNLDYIAV DEGFSFGGWE IRPWKVTHGA NGFSFALRFD RKEDYSFVYC PDSIGLDERE
KAPMRDVDLL VLGTSFYKEE GAGRSVYDVT EALELLREVK PSRTVFTHLS HGIDLLEDYA
LPSGVRFAQA GLSIALSRDS G
//
