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Database: UniProt
Entry: F5R9J4_METUF
LinkDB: F5R9J4_METUF
Original site: F5R9J4_METUF 
ID   F5R9J4_METUF            Unreviewed;       205 AA.
AC   F5R9J4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   08-MAY-2019, entry version 38.
DE   RecName: Full=Thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE            EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE   AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN   Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN   ORFNames=METUNv1_00903 {ECO:0000313|EMBL:EGK73064.1};
OS   Methyloversatilis universalis (strain ATCC BAA-1314 / JCM 13912 /
OS   FAM5).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales;
OC   Sterolibacteriaceae; Methyloversatilis.
OX   NCBI_TaxID=1000565 {ECO:0000313|EMBL:EGK73064.1, ECO:0000313|Proteomes:UP000005019};
RN   [1] {ECO:0000313|EMBL:EGK73064.1, ECO:0000313|Proteomes:UP000005019}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1314 / JCM 13912 / FAM5
RC   {ECO:0000313|Proteomes:UP000005019};
RX   PubMed=21725020; DOI=10.1128/JB.05331-11;
RA   Kittichotirat W., Good N.M., Hall R., Bringel F., Lajus A.,
RA   Medigue C., Smalley N.E., Beck D., Bumgarner R., Vuilleumier S.,
RA   Kalyuzhnaya M.G.;
RT   "Genome sequence of Methyloversatilis universalis FAM5T, a
RT   methylotrophic representative of the order Rhodocyclales.";
RL   J. Bacteriol. 193:4541-4542(2011).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis. {ECO:0000256|HAMAP-
CC       Rule:MF_00165}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC         ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00165, ECO:0000256|SAAS:SAAS01114966};
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000256|SAAS:SAAS01070220}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EGK73064.1}.
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DR   EMBL; AFHG01000030; EGK73064.1; -; Genomic_DNA.
DR   RefSeq; WP_008059247.1; NZ_AFHG01000030.1.
DR   STRING; 1000565.METUNv1_00903; -.
DR   EnsemblBacteria; EGK73064; EGK73064; METUNv1_00903.
DR   eggNOG; ENOG4108ZMD; Bacteria.
DR   eggNOG; COG0125; LUCA.
DR   OrthoDB; 1585072at2; -.
DR   BioCyc; GCF_000214035:G1EEC-3349-MONOMER; -.
DR   Proteomes; UP000005019; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039430; Thymidylate_kin-like_dom.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   Pfam; PF02223; Thymidylate_kin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070209};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005019};
KW   Kinase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070206, ECO:0000313|EMBL:EGK73064.1};
KW   Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070211};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070205};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005019};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_00165,
KW   ECO:0000256|SAAS:SAAS01070204}.
FT   DOMAIN        9    195       Thymidylate_kin. {ECO:0000259|Pfam:
FT                                PF02223}.
FT   NP_BIND      11     18       ATP. {ECO:0000256|HAMAP-Rule:MF_00165}.
SQ   SEQUENCE   205 AA;  22619 MW;  CB1E7C874D1646E2 CRC64;
     MHNTRFITFE GMDGAGKSTQ IARTADWLRA RGHAVLLTRE PGGTPLGESL RGLLLHEAMH
     PDTEALLMFA ARREHLAQVI EPALGRGDWV LCDRFTDASF AYQGGGRGLD IARLQALEAW
     VQRGLQPGLT LLFDLPCEVA AQRLAASGGD PDRFEREQSD FFNRVRAAYL ARAQADPGRM
     QVLNAARSPE EVSAQLEEIL SRYCS
//
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