ID F5X3L0_STRPX Unreviewed; 271 AA.
AC F5X3L0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Foldase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|HAMAP-Rule:MF_01811};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN Name=yidC.2 {ECO:0000313|EMBL:BAK30869.1};
GN Synonyms=yidC {ECO:0000256|HAMAP-Rule:MF_01811};
GN OrderedLocusNames=SGPB_1869 {ECO:0000313|EMBL:BAK30869.1};
OS Streptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=981540 {ECO:0000313|EMBL:BAK30869.1, ECO:0000313|Proteomes:UP000007946};
RN [1] {ECO:0000313|EMBL:BAK30869.1, ECO:0000313|Proteomes:UP000007946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43144 / JCM 5346 / CDC 1723-81
RC {ECO:0000313|Proteomes:UP000007946};
RX PubMed=21633709; DOI=10.1371/journal.pone.0020519;
RA Lin I.-H., Liu T.-T., Teng Y.-T., Wu H.-L., Liu Y.-M., Wu K.-M.,
RA Chang C.-H., Hsu M.-T.;
RT "Sequencing and comparative genome analysis of two pathogenic Streptococcus
RT gallolyticus subspecies: genome plasticity, adaptation and virulence.";
RL PLoS ONE 6:E20519-E20519(2011).
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. {ECO:0000256|HAMAP-Rule:MF_01811}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01811}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01811}.
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DR EMBL; AP012054; BAK30869.1; -; Genomic_DNA.
DR RefSeq; WP_003066687.1; NC_015600.1.
DR AlphaFoldDB; F5X3L0; -.
DR STRING; 981540.SGPB_1869; -.
DR GeneID; 64019756; -.
DR KEGG; stb:SGPB_1869; -.
DR HOGENOM; CLU_036138_5_0_9; -.
DR Proteomes; UP000007946; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR HAMAP; MF_01811; YidC_type2; 1.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR023060; YidC/YidC1/YidC2_Firmicutes.
DR InterPro; IPR047196; YidC_ALB_C.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01811};
KW Chaperone {ECO:0000256|HAMAP-Rule:MF_01811};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01811};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01811}; Reference proteome {ECO:0000313|Proteomes:UP000007946};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|HAMAP-Rule:MF_01811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01811};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01811}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..271
FT /note="Membrane protein insertase YidC"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038849530"
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 192..211
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT TRANSMEM 217..235
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01811"
FT DOMAIN 55..236
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
FT REGION 249..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 31156 MW; 41FCA83F415D7EC2 CRC64;
MKRKIKLLGL SSLTLILLAA CGRSEVTASS TNGWDQIVYF FAKAIQWLSI NGRIGVGIVL
FTIIIRAIMM PLYNMQIKSG QKMQDLQPEL KKLQEKYPGR DTDSRMKLTE ESQALYKEYG
VNPYATMLPL VVQLPILMAL YQALTRVAFL KTGTFLWIEL SKPDPYFILP VLAALFTFLS
SWLTNKAARE KNIAMTVMTY VMPIMIFFMS FRLASGVVLY WSVSYAFQVF QILLLNNPFK
IIAKRLEEEQ AEKERSAKIR RAKKKAQKRR K
//
