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Database: UniProt
Entry: F5YPZ7_TREPZ
LinkDB: F5YPZ7_TREPZ
Original site: F5YPZ7_TREPZ 
ID   F5YPZ7_TREPZ            Unreviewed;       847 AA.
AC   F5YPZ7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Bifunctional aspartokinase/homoserine dehydrogenase I {ECO:0000313|EMBL:AEF84522.1};
DE            EC=1.1.1.3 {ECO:0000313|EMBL:AEF84522.1};
DE            EC=2.7.2.4 {ECO:0000313|EMBL:AEF84522.1};
GN   OrderedLocusNames=TREPR_2791 {ECO:0000313|EMBL:AEF84522.1};
OS   Treponema primitia (strain ATCC BAA-887 / DSM 12427 / ZAS-2).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
OX   NCBI_TaxID=545694 {ECO:0000313|EMBL:AEF84522.1, ECO:0000313|Proteomes:UP000009223};
RN   [1] {ECO:0000313|Proteomes:UP000009223}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-887 / DSM 12427 / ZAS-2
RC   {ECO:0000313|Proteomes:UP000009223};
RA   Tetu S.G., Matson E., Ren Q., Seshadri R., Elbourne L., Hassan K.A.,
RA   Durkin A., Radune D., Mohamoud Y., Shay R., Jin S., Zhang X.,
RA   Lucey K., Ballor N.R., Ottesen E., Rosenthal R., Allen A.,
RA   Leadbetter J.R., Paulsen I.T.;
RT   "Complete sequence of Treponema primitia strain ZAS-2.";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AEF84522.1, ECO:0000313|Proteomes:UP000009223}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-887 / DSM 12427 / ZAS-2
RC   {ECO:0000313|Proteomes:UP000009223};
RX   PubMed=21326336; DOI=10.1038/ismej.2011.3;
RA   Rosenthal A.Z., Matson E.G., Eldar A., Leadbetter J.R.;
RT   "RNA-seq reveals cooperative metabolic interactions between two
RT   termite-gut spirochete species in co-culture.";
RL   ISME J. 5:1133-1142(2011).
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DR   EMBL; CP001843; AEF84522.1; -; Genomic_DNA.
DR   STRING; 545694.TREPR_2791; -.
DR   EnsemblBacteria; AEF84522; AEF84522; TREPR_2791.
DR   KEGG; tpi:TREPR_2791; -.
DR   eggNOG; ENOG4105CFH; Bacteria.
DR   eggNOG; COG0460; LUCA.
DR   eggNOG; COG0527; LUCA.
DR   KO; K12524; -.
DR   OMA; CNKIACS; -.
DR   Proteomes; UP000009223; Chromosome.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009067; P:aspartate family amino acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR011147; Bifunc_aspartokin/hSer_DH.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF13840; ACT_7; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000727; ThrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 2.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009223};
KW   Kinase {ECO:0000313|EMBL:AEF84522.1};
KW   Oxidoreductase {ECO:0000313|EMBL:AEF84522.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009223};
KW   Transferase {ECO:0000313|EMBL:AEF84522.1}.
FT   DOMAIN      338    412       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   DOMAIN      419    494       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   847 AA;  90033 MW;  69F75004005424AF CRC64;
     MIFYGMPVFE NIAVFQGDLF MVVLKFGGTS VGSPEAIRKL IGILGDSEHA GKVRVVVVSA
     LSGVTDSLIG LARQAAEGEV ARAALKTLEE RHRKISHAFL AGTERQETDA AIKASFAELS
     RTLDGIGILR ELSPRSFDYV MSFGERLSAA LLAHICTAQG VQAEYLDARP LVLTDGNYGS
     ARYQGDESYS RIRSYLKKHP ALQIATGFIG SNAEGHTTTL GRGGSDLSAA IFGAAMGAKC
     VEIWTDVDGI LTADPKLVKT AFKIDSLSYN EAMELSHFGA KVLHPPTVRP ALEKGIPIVI
     RNTFNPPGGG TRIADDADPG NYPIRGISSM GNVTLVRVQG SGMVGMTGFS ARLFGALARK
     GISIILITQA SSEYSICVVV APQDGPLAAA VIGEEFEREI ASGAIEAPAV MEDLAIIAVV
     GSNMEHTTGI SGKVFHALGR NGINVVAIAQ GSSEINISAV IGAQDVAKAL NAIHEAFFLA
     GVRTVNLFLI GIGNIGGTLL DQITSHKETL ADQYKIRINL VGVANSSRMI FNPAGLEPKK
     IRGVLSSGDI KQGSAGTELL PLTLPEFIRK MKSFNLPTTA FCDCTANPDV AAVYAEILQA
     AIPVVTPNKR ANSGSLDYYK TITGYSRDRG IPYLYETTVC AGLPVISVLR DLALSGDKVR
     RIEAVLSGTL SFIFNNFDGS KTFSALVREA KAKGYTEPDP RDDLNAMDAA RKALILAREC
     GMSLEFPAVA IEPILPPSCF KANGVEAFFT ELEKADADFE KRRLEAAKEG KVLRYVSIIE
     EGSARLSLRA ESPGSPFLSL VDSDNIVVIT TDRYSKLPMV IKGPGAGAQV TAGGVFADIL
     RIARTLV
//
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